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Respiratory tract infection eliminated in 36 percent of people by 4000 IU of Vitamin D – RCT Sept 2015

Vitamin D supplementation to patients with frequent respiratory tract infections: a post hoc analysis of a randomized and placebo-controlled trial

BMC Research Notes 2015, 8:391 doi:10.1186/s13104-015-1378-3
Peter Bergman 1 peter.bergman at ki.se, Anna-Carin Norlin2, Susanne Hansen3 and Linda Björkhem-Bergman1
1 Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, 141 86, Sweden
2 Division of Clincal Immunology, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, 141 86, Sweden
3 Infectious Disease Clinic, Karolinska University Hospital, Stockholm, 141 86, Sweden
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Background
Vitamin D is considered to be important for a healthy immune system. The aim of this study was to test the hypothesis that vitamin D supplementation reduces number of respiratory tract infections (RTIs) and prolong the time to the first RTI in adult patients with frequent RTIs.

Methods
We performed a post hoc analysis of a randomized, placebo-controlled and double-blinded study, where adult patients with a high burden of RTIs were randomized to placebo or vitamin D (4000 IE/day for 1 year, n = 124 in the per protocol cohort presented here).

Results
Vitamin D supplementation increased the probability to stay free of RTI during the study year (RR 0.64, 95 % CI 0.43–0.94).
Further, the total number of RTIs was also reduced in the vitamin D-group (86 RTIs) versus placebo (120 RTIs; p = 0.05).
Finally, the time to the first RTI was significantly extended in the vitamin D-group (HR 1.68, 95 % CI 1.03–2.68, p = 0.0376).

Conclusion
Vitamin D supplementation was found to significantly increase the probability of staying infection free during the study period. This finding further supports the notion that vitamin D-status should be monitored in adult patients with frequent RTIs and suggests that selected patients with vitamin D deficiency are supplemented. This could be a safe and cheap way to reduce RTIs and improve health in this vulnerable patient population.


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Yes, takes 2-3 months to get the benefits of vitamin D if no initial loading dose is used.

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Attached files

ID Name Comment Uploaded Size Downloads
5951 Bergman 2012.pdf PDF admin 21 Sep, 2015 15:47 512.65 Kb 383
5884 RTI BMC.jpg admin 05 Sep, 2015 14:51 20.85 Kb 546
5883 RTI BMC.pdf PDF 2015 admin 05 Sep, 2015 14:51 908.78 Kb 334
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