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Respiratory tract infection eliminated in 36 percent of people by 4000 IU of Vitamin D – RCT Sept 2015

Vitamin D supplementation to patients with frequent respiratory tract infections: a post hoc analysis of a randomized and placebo-controlled trial

BMC Research Notes 2015, 8:391 doi:10.1186/s13104-015-1378-3
Peter Bergman 1 peter.bergman at ki.se, Anna-Carin Norlin2, Susanne Hansen3 and Linda Björkhem-Bergman1
1 Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, 141 86, Sweden
2 Division of Clincal Immunology, Karolinska Institutet and Karolinska University Hospital Huddinge, Stockholm, 141 86, Sweden
3 Infectious Disease Clinic, Karolinska University Hospital, Stockholm, 141 86, Sweden
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Background
Vitamin D is considered to be important for a healthy immune system. The aim of this study was to test the hypothesis that vitamin D supplementation reduces number of respiratory tract infections (RTIs) and prolong the time to the first RTI in adult patients with frequent RTIs.

Methods
We performed a post hoc analysis of a randomized, placebo-controlled and double-blinded study, where adult patients with a high burden of RTIs were randomized to placebo or vitamin D (4000 IE/day for 1 year, n = 124 in the per protocol cohort presented here).

Results
Vitamin D supplementation increased the probability to stay free of RTI during the study year (RR 0.64, 95 % CI 0.43–0.94).
Further, the total number of RTIs was also reduced in the vitamin D-group (86 RTIs) versus placebo (120 RTIs; p = 0.05).
Finally, the time to the first RTI was significantly extended in the vitamin D-group (HR 1.68, 95 % CI 1.03–2.68, p = 0.0376).

Conclusion
Vitamin D supplementation was found to significantly increase the probability of staying infection free during the study period. This finding further supports the notion that vitamin D-status should be monitored in adult patients with frequent RTIs and suggests that selected patients with vitamin D deficiency are supplemented. This could be a safe and cheap way to reduce RTIs and improve health in this vulnerable patient population.


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Attached files

ID Name Comment Uploaded Size Downloads
5951 Bergman 2012.pdf admin 21 Sep, 2015 512.65 Kb 1191
5884 RTI BMC.jpg admin 05 Sep, 2015 20.85 Kb 1601
5883 RTI BMC.pdf admin 05 Sep, 2015 908.78 Kb 1044