Left ventricular adverse remodeling after myocardial infarction and its association with vitamin D levels.
Int J Cardiol. 2018 Aug 18. pii: S0167-5273(18)30354-1. doi: 10.1016/j.ijcard.2018.08.052.
Padoan L1, Beltrami AP2, Stenner E3, Beleù A1, Ruscio M3, Sinagra G1, Aleksova A4.
1 Cardiovascular Department, Azienda Sanitaria Universitaria Integrata di Trieste and University of Trieste, Trieste, Italy.
2 Department of Medical and Biological Sciences, University of Udine, Italy.
3 Department of Laboratory Medicine, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy.
4 Cardiovascular Department, Azienda Sanitaria Universitaria Integrata di Trieste and University of Trieste, Trieste, Italy. aaleksova at units.it.
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Angina dramatically reduced by injections of vitamin D twice a month (300,000 IU) – Jan 2015
- Heart problems such as Afib related to little Magnesium, Omega-3, Vitamin D getting to tissues
- Vitamin D reduces chance of a second heart attack and death – Jan 2017
Cardiovascular category starts with the following
- Overview Cardiovascular and vitamin D
- Hypertension and vitamin D
- Overview Metabolic Syndrome and vitamin D
- Overview Stroke and vitamin D
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
Meta-analyses (auto-updated)
- Arterial stiffness reduced if use at least 2,000 IU of Vitamin D for 4 months – meta-analysis Dec 2019
- Blood vessels not helped by small vitamin D doses – meta-analysis Dec 2019
- Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis July 2018
- Low-dose vitamin D does not help cardiovascular (many were 100-1,000 IU) – meta-analysis June 2019
- Heart Failure and Vitamin D meta-analyses - 2016, 2019
- Vitamin K (across all dose sizes and types) decrease Vascular Stiffness – meta-analysis - Dec 2018
- Small or infrequent doses of vitamin D do not reduce heart failure much – meta-analysis Jan 2018
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Omega-3 reduced time in hospital and atrial fibrillation after cardiac surgery – meta-analysis May 2016
- Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017
- Health problems prevented by eating nuts (perhaps due to Magnesium and or Omega-3) – meta-analysis Dec 2016
- Atrial Fibrillation 1.3 times more likely if low vitamin D – meta-analysis Sept 2016
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
- Chronic Heart Failure not treated by Vitamin D, if dose size is ignored – meta-analysis Oct 2015
- Atrial fibrillation sometimes treated by Omega-3 – meta-analysis Sept 2015
- Peripheral Arterial Disease patients have low vitamin D levels – meta-analysis Oct 2015
- C-reactive protein (heart disease marker) reduced by vitamin D – meta-analysis 2014, 2019
- Cardiovascular disease associated with postmenopausal non-human primates – meta-analysis Jan 2015
- Adding Calcium does NOT cause cardiovascular problems (reverses their meta-analysis) – Dec 2014
- Statin pain associated with 10 ng less vitamin D – meta-analysis Oct 2014
- Risk of Cardiac failure reduced 20 percent by 800 IU of vitamin D and Calcium – meta-analysis July 2014
- Magnesium prevents cardiovascular events – Meta-analysis March 2013
- Cardiovascular disease 50 % more likely if low vitamin D - meta-analysis Nov 2012
- Omega-3 does not help heart patients – meta-analysis Sept 2012
- Half as many heart deaths for those with high levels of vitamin D – meta-analysis Sept 2012
- Shift workers 23 percent more likely to have cardiovascular events – meta-analysis July 2012
- Low density lipoprotein cholesterol is predictable from vitamin D levels – meta-analysis March 2012
- 800 IU Vitamin D does not help heart – meta-analysis Aug 2011
- Calcium without vitamin D increased heart risk by 30 percent - Jan 2011
- Meta-analysis unsure if vitamin D can prevent cardiovascular disease – Sept 2010
Omega-3 Helps (auto-updated)
- Omega-3 reduced cardiovascular deaths by 16 percent (427,678 people) – March 2020
- Synthetic EPA drug recommended to FDA for Cardio (Omega-3 is 8 X better) – Nov 2019
- Omega-3 reduces heart problems by ~5 percent – meta-analysis by Heart Association Oct 2019
- Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019
- Few people have enough EPA (an Omega-3) to reduce heart failures – July 2019
- Another Nail in the Coffin for Fish Oil Supplements (nope) – JAMA April 2018
- Omega-3 provides many cardiovascular benefits – April 2018
- Omega-3 helps the heart, AHA class II recommendation, more than 1 gm may be needed – March 2018
- 3 days of Omega-3 before cardiac surgery reduced risk of post-op bleeding by half – RCT March 2018
- Perhaps the Omega-3 optimal level is 10 percent, not 8 – Feb 2018
- Omega-3 Cardiovascular meta-analysis has at least 5 major problems – Jan 2018
- Benefits of Omega-3 beyond heart health - LEF Feb 2018
- Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017
- Cardiovascular problems reduced by low dose aspirin and perhaps Omega-3 (also Vit K) – Sept 2017
- Omega-3 reduced time in hospital and atrial fibrillation after cardiac surgery – meta-analysis May 2016
- For every Omega-3 dollar there is a 84 dollar savings in Cardiovascular costs - Foster and Sullivan April 2016
- High dose Omega-3 probably reduces heart problems – American Heart Association – March 2017
- Health problems prevented by eating nuts (perhaps due to Magnesium and or Omega-3) – meta-analysis Dec 2016
- Omega-3 – need more than 1 gram for a short time to reduce Cardiovascular Disease – Nov 2016
- Omega-3 is vital for health, mail-in test is low cost and accurate
- Cardiovascular calcification prevented by Omega-3, Magnesium, Vitamin K, and Vitamin D – April 2015
- Atrial fibrillation sometimes treated by Omega-3 – meta-analysis Sept 2015
- Salmon intervention (vitamin D and Omega-3) improved heart rate variability and reduced anxiety – Nov 2014
- Omega-7 - in addition to Omega-3
- Omega-3 reduces Coronary Heart Disease - infographic June 2014
- Cardiovascular diseases – conflicting data on benefits of Omega-3 and vitamin D – Feb 2014
- Cardiovascular system benefits from both Omega-3 and vitamin D – Dec 2012
- Heart problems such as Afib related to little Magnesium, Omega-3, Vitamin D getting to tissues
- Omega-3 does not help heart patients – meta-analysis Sept 2012
A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues
- Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and vitamin D statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
From the web
PDF is available free at Sci-Hub 10.1016/j.ijcard.2018.08.052.
Background: Vitamin D, a potential cardiovascular risk biomarker, has an unclear role in the adverse left ventricle remodeling (LVAR) after acute myocardial infarction (AMI).
Methods: to evaluate the impact of Vitamin D levels on LVAR in a prospective cohort study of patients with AMI.
Results: 253 patients with AMI were studied, 81 of which (32%) developed, in median 4.1 months after AMI, LVAR. Age, sex, risk factors, type and location of the infarction, clinical presentation, timing and mode of revascularization did not differ between patients with and without LVAR. However, patients with LVAR had lower Vitamin D levels (12.6 vs. 18.7 ng/mL, p <0.001), while higher Vitamin D at baseline protected against LVAR (for increase of 10 ng/ml HR 0.74, CI 0.61-0.90, p <0.001). Plasma levels of C Reactive Protein (CRP), peak Troponin I, indexed left ventricular end systolic volume (LVESVI) and NYHA class at discharge predicted, in multivariate analysis, LVAR occurrence at follow-up. Moreover, the inclusion of Vitamin D improved the multivariate model, as shown by the area under the ROC curve (HR 0.82; CI 0.76-0.88, p<0.001). During the follow-up of 25.5 (777) months, patients with LVAR had a worse event-free survival rate (HF, p=0.012; combined event HF/mortality, p=0.006), even when the analysis was restricted to patients with ST-elevation MI (p=0.006).
Conclusions: low Vitamin D levels are associated with post-infarct LVAR.
PMID: 30139699 DOI: 10.1016/j.ijcard.2018.08.052
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