Left ventricular adverse remodeling after myocardial infarction and its association with vitamin D levels.
Int J Cardiol. 2018 Aug 18. pii: S0167-5273(18)30354-1. doi: 10.1016/j.ijcard.2018.08.052.
Padoan L1, Beltrami AP2, Stenner E3, Beleù A1, Ruscio M3, Sinagra G1, Aleksova A4.
1 Cardiovascular Department, Azienda Sanitaria Universitaria Integrata di Trieste and University of Trieste, Trieste, Italy.
2 Department of Medical and Biological Sciences, University of Udine, Italy.
3 Department of Laboratory Medicine, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy.
4 Cardiovascular Department, Azienda Sanitaria Universitaria Integrata di Trieste and University of Trieste, Trieste, Italy. aaleksova at units.it.
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Angina dramatically reduced by injections of vitamin D twice a month (300,000 IU) – Jan 2015
- Heart problems such as Afib related to little Magnesium, Omega-3, Vitamin D getting to tissues
- Vitamin D reduces chance of a second heart attack and death – Jan 2017
Cardiovascular category starts with the following
- Overview Cardiovascular and vitamin D
- Hypertension and vitamin D
- Overview Metabolic Syndrome and vitamin D
- Overview Stroke and vitamin D
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
Meta-analyses
- Heart Failure and Vitamin D meta-analyses - 2016, 2019
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis July 2018
Omega-3 Helps
- Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019
- Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017
A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues
- Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and vitamin D statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
From the web
PDF is available free at Sci-Hub 10.1016/j.ijcard.2018.08.052.
Background: Vitamin D, a potential cardiovascular risk biomarker, has an unclear role in the adverse left ventricle remodeling (LVAR) after acute myocardial infarction (AMI).
Methods: to evaluate the impact of Vitamin D levels on LVAR in a prospective cohort study of patients with AMI.
Results: 253 patients with AMI were studied, 81 of which (32%) developed, in median 4.1 months after AMI, LVAR. Age, sex, risk factors, type and location of the infarction, clinical presentation, timing and mode of revascularization did not differ between patients with and without LVAR. However, patients with LVAR had lower Vitamin D levels (12.6 vs. 18.7 ng/mL, p <0.001), while higher Vitamin D at baseline protected against LVAR (for increase of 10 ng/ml HR 0.74, CI 0.61-0.90, p <0.001). Plasma levels of C Reactive Protein (CRP), peak Troponin I, indexed left ventricular end systolic volume (LVESVI) and NYHA class at discharge predicted, in multivariate analysis, LVAR occurrence at follow-up. Moreover, the inclusion of Vitamin D improved the multivariate model, as shown by the area under the ROC curve (HR 0.82; CI 0.76-0.88, p<0.001). During the follow-up of 25.5 (777) months, patients with LVAR had a worse event-free survival rate (HF, p=0.012; combined event HF/mortality, p=0.006), even when the analysis was restricted to patients with ST-elevation MI (p=0.006).
Conclusions: low Vitamin D levels are associated with post-infarct LVAR.
PMID: 30139699 DOI: 10.1016/j.ijcard.2018.08.052
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