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Psychotic problems associated with low vitamin D – review Sept 2021

The association between vitamin D and symptom domains in psychotic disorders: A systematic review

Schizophr Res . 2021 Sep 8;237:79-92. doi: 10.1016/j.schres.2021.08.001 - PDF is behind a paywall
Jonathan Tsiglopoulos 1, Nicholas Pearson 1, Nathan Mifsud 1, Kelly Allott 1, Brian O'Donoghue 2


NOTE: This review probably ignores
dose size,
dose duration.
dose type,
any use of Omega-3,
initial vitamin D level in RCTs
low vitamin D as child or in utero, etc.

Intervention of Vitamin D for Depression

Meta-analyses of Depression

Meta-analyses of Omega-3 and Depression

Depression summary

Anxiety studies include

8 VitaminDWiki pages with ANXIETY in title
This list is automatically updated

Items found: 11

Cognitive category starts with the following

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used

352 items in Cognition category

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Studies in both categories of Cognition and:
Cardiovascular (6 studies), Genetics (9 studies), Vitamin D Receptor (16 studies), Omega-3 (48 studies), Intervention (18 studies), Meta-analyses (21 studies), Depression (21 studies), Parkinson's (19 studies),  Click here for details

Dementia is associated with low vitamin D - many studies 50+
Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 325 items as of March 2023

Types of evidence that Vitamin D helps brain problems - 2014

Overview Schizophrenia and Vitamin D contains the following summary

14 reasons to think that schizophrenia is associated with low vitamin D
1) 97% of patients with schizophrenia are vitamin D deficient
2) Schizophrenia varies with latitude (UVB) by 10X (controversy)
3) Schizophrenia is more common in those with dark skin (when away from the equator)
4) Schizophrenia is associated with low natal vitamin D
5) Schizophrenia has been increasing around the world when vitamin D has been decreasing (controversy)
6) Schizophrenia is associated with low birth rate, which is associated with low vitamin D
7) Schizophrenia is associated with Autism which is associated with low vitamin D
8) Schizophrenia Bulletin Editorial (Jan 2014) speculated that Vitamin D could be a major player
9) Schizophrenia 2X more likely if low vitamin D - meta-analysis
10) Schizophrenia increased 40 % for Spring births after Danes stopped vitamin D fortification
11) Schizophrenia is associated with season of birth
12) Schizophrenia is associated with poor Vitamin D Receptor genes
13) Schizophrenia risk is decreased if give Vitamin D after birth
14) Schizophrenia symptoms reduced when Vitamin D levels are restored

Background: Vitamin D deficiency is prevalent among people with psychosis and may play a role in the aetiology of psychotic disorders. However, its impact on clinical symptom severity has not been independently reviewed.

Methods: We conducted a systematic search of randomized trials and observational studies that assessed the relationship between vitamin D and symptom domains (positive and negative psychotic symptoms, total and general psychopathology, cognitive and depressive) in people with a psychotic disorder.

Results: 1040 articles were identified, of which 29 were eligible for inclusion: 26 observational studies and 3 randomized trials. Five studies included people with First-Episode Psychosis (FEP) and 24 included people with enduring psychosis. Most observational studies found that vitamin D was

  • inversely associated with negative symptoms (57%; 13/23),
  • positively associated with cognitive performance (63%; 5/8), and
  • bore no association with positive symptoms (68%; 15/22),
    • total psychopathology (64%; 7/11),
    • general psychopathology (57%; 4/7) or
    • depressive symptoms (64%; 9/14).

Randomized controlled trials indicated that vitamin D supplementation

  • improved cognitive performance (100%; 1/1) and, in some cases,


  • total psychopathology (50%; 1/2),
  • general psychopathology (50%; 1/2) and
  • negative symptoms (30%; 1/3), but had
  • no effect on positive (100%; 3/3) or depressive (100%; 3/3) symptoms.

Some positive associations were attenuated when controlled for potential confounders.

Conclusion: Low vitamin D was found to be inversely associated with more severe clinical symptoms in some, but not all symptom domains in people with psychosis. These preliminary findings warrant further exploration, particularly in regard to cognitive performance and negative symptoms.

Created by admin. Last Modification: Sunday September 12, 2021 14:35:35 GMT-0000 by admin. (Version 6)