Incidence of hypercalciuria and hypercalcemia during vitamin D and calcium supplementation in older women.
Menopause, doi: 10.1097/GME.0000000000000270
Gallagher, John Christopher MD; Smith, Lynette M. MSc; Yalamanchili, Vinod MD
Objective: This study aims to prospectively assess the incidence of hypercalciuria and hypercalcemia with different doses of vitamin D and with a calcium intake of approximately 1,200 mg/day.
Methods: This was a 1-year randomized placebo-controlled study of vitamin D (400-4,800 IU/d) in 163 white women aged 57 to 90 years. Calcium citrate tablets (200 mg) were added to the diet to achieve a total calcium intake of approximately 1,200 mg/day in all groups. All women had vitamin D insufficiency at baseline, with serum 25-hydroxyvitaminD levels lower than 20 ng/mL (50 nmol/L). Serum and 24-hour urine calcium were collected every 3 months on supplementation, any test result above the upper reference range represented an episode of hypercalcemia or hypercalciuria. Mixed-effects models and multivariate logistic regression were used in the analysis.
Results: Hypercalcemia (>10.2 mg/dL [2.55 mmol/L]) occurred in 8.8% of white women. Hypercalciuria (>300 mg/d 7.5 mmol]) occurred in 30.6% of white women. Episodes of hypercalciuria were transient in half of the group and recurrent in the other half. No relationship between hypercalcemia or hypercalciuria and vitamin D dose was found, and hypercalciuria was equally common in the placebo group.
Conclusions: Hypercalciuria and hypercalcemia commonly occur with vitamin D and calcium supplements. Whether hypercalciuria and hypercalcemia are caused by calcium, vitamin D, or both is unclear. These findings may have relevance to the reported increase in kidney stones in the Women's Health Initiative trial. Because calcium 1,200 mg and vitamin D 800 IU/day are widely recommended in postmenopausal women, systematic evaluation of the safety of supplements is warranted in clinical management and in future studies.
- The researchers found no relationship between hypercalcemia or hypercalciuria and vitamin D dose, and hypercalciuria was equally frequent in the placebo group.
- ‘“Even a modest calcium supplementation of 500 mg/day may be too high for some women,” the authors note in a news release.
Note: Hypercalcemia or hypercalciuria rates were high with 1200 mg of Calcium – even if NO vitamin D was taken.
- Calcium bioavailability and how much to take
- All items with Calcium in VitaminDWiki
- Must balance co-factors when increasing vitamin D 500 Ca, 500 Mg - which has the following concept graph
Proven yet again – more than 500 mg of Calcium can be a problem – RCT June 2014
- IoM again fails to look at interactions - Nov 2010
has the graph: dangerous to have too much Calcium while having lots of vitamin D
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