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Prostate Cancer PSA reduced by 60 ng of Vitamin D, Vitamin B complex, Omega-3, Curcumin and diet – June 2021


Correlative Analysis of Vitamin D and Omega-3 Fatty Acid Intake in Men on Active Surveillance for Prostate Cancer

Urology. 2021 Jun 15;S0090-4295(21)00525-2. doi: 10.1016/j.urology.2021.04.050
Rebecca A Campbell 1, Jianbo Li 2, Lindsay Malone 3, David A Levy 4

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Objectves: To investigate the influence of targeted serum vitamin-D level and omega-6:3 fatty-acid ratio on prostate-specific antigen (PSA) level in men with prostate cancer managed with active surveillance by providing a nutritional intervention and vitamin supplementation.

Methods: Sixty-eight patients with biopsy-proven NCCN very-low or low-risk prostate cancer were enrolled in the prostate cancer nutrition and genetics clinic at the Cleveland Clinic from July 2013-December 2019. Patients adhered to a specific dietary regimen devoid of animal-based products and foods containing omega-6 polyunsaturated fatty acids (PUFAs). The supplement regimen consisted of: Omega-3 PUFAs 720mg (three/day); curcumin 2000 mg/day; vitamin D3 dose titrated to achieve serum level of 60 ng/ml; and vitamin B-complex 1000 mg (four times weekly). Patients underwent periodic monitoring of PSA, serum vitamin D, and PUFA levels and had frequent follow-up with the nutritionist which included a food frequency questionnaire. Interval prostate biopsy was performed as clinically indicated and/or at nine months.

Results: The mean and 95% confidence interval (CI) of PSA slope and Vitamin D serum levels slope were 0.11 (0-0.25) ng/mL/month and 4.65 (3.09-5.98) ng/mL/month, respectively. Patients with higher initial vitamin D levels were twice as likely to have a downward PSA trend (OR=2.04, 95% CI 1.04-4.01, p=0.04). Fifty-five patients underwent follow-up biopsy, all showing no progression of disease. Three patients had loose bowel movements that required omega-3 and or curcumin dose adjustments.

Conclusions: Intensive nutritional intervention with Vitamin D and Omega-3 PUFA supplementation may benefit men on active surveillance for prostate cancer and further studies are warranted.

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References

IARC Publications Website - World Cancer Report 2014. Accessed July 30, 2020. https://publications.iarc.fr/Non-Series-Publications/World-Cancer-Reports/World-Cancer-Report-2014
Surveillance, Epidemiology, and End Results (SEER). Cancer Statistics Review (CSR). Accessed July 31, 2020. https://seer.cancer.gov/archive/csr/1975_2013/
Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline. Part I: Risk Stratification, Shared Decision Making, and Care Options.
J Urol. 2018; 199: 683-690 https://doi.org/10.1016/j.juro.2017.11.095
Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer (Sweden); Cancer Causes Control. 1998; 9: 559-566 https://doi.org/10.1023/A:1008823601897
Glycemic index, glycemic load and risk of prostate cancer. Int J Cancer. 2004; 112: 446-450 https://doi.org/10.1002/ijc.20416
A prospective study of dietary fat and risk of prostate cancer - PubMed.J Natl Cancer Inst. 1993; 85 (Accessed July 31, 2020): 1571-1579
https://pubmed.ncbi.nlm.nih.gov/8105097/
Impact of consumption of vegetable, fruit, grain, and high glycemic index foods on aggressive prostate cancer risk. Nutr Cancer. 2011; 63: 860-872 https://doi.org/10.1080/01635581.2011.582224
Associations of circulating 25-hydroxyvitamin D with prostate cancer diagnosis, stage and grade. Int J Cancer. 2012; 131: 1187-1196
https://doi.org/10.1002/ijc.27327
Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: a nested case–control study. Cancer Causes Control. 2015; 26: 205-218 https://doi.org/10.1007/s10552-014-0500-5
Vitamin D deficiency predicts prostate biopsy outcomes. Clin Cancer Res. 2014; 20: 2289-2299 https://doi.org/10.1158/1078-0432.CCR-13-3085
Dietary PUFA and cancer. in: Proceedings of the Nutrition Society. 73. Cambridge University Press, 2014: 361-367
https://doi.org/10.1017/S0029665114000585
Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids.J Clin Invest. 2007; 117: 1866-1875 https://doi.org/10.1172/JCI31494
Docosahexaenoic acid induces proteasome-dependent degradation of β-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2. Carcinogenesis. 2006; 28: 1202-1209
https://doi.org/10.1093/carcin/bgl254
Dietary fat-gene interactions in cancer.
Cancer Metastasis Rev. 2007; 26: 535-551
https://doi.org/10.1007/s10555-007-9075-x
et al.
Prostate cancer, version 2.2019.
JNCCN J Natl Compr Cancer Netw. 2019; 17: 479-505
https://doi.org/10.6004/jnccn.2019.0023
View in Article
Scopus (348)
PubMed
Crossref
Google Scholar
Food Frequency Questionnaire at a Glance | Dietary Assessment Primer. Accessed August 3, 2020. https://dietassessmentprimer.cancer.gov/profiles/questionnaire/

View in Article
Google Scholar
Subar AF
Thompson FE
Kipnis V
et al.
Comparative validation of the Block, Willett, and National Cancer Institute Food Frequency Questionnaires: The Eating at America's Table Study.
Am J Epidemiol. 2001; 154: 1089-1099
https://doi.org/10.1093/aje/154.12.1089
View in Article
Scopus (909)
PubMed
Crossref
Google Scholar
Garland CF
French CB
Baggerly LL
Heaney RP.
Vitamin D supplement doses and serum 25-Hydroxyvitamin D in the range associated with cancer prevention.
Anticancer Research. 2011; (PublishedAccessed July 29, 2020)
http://ar.iiarjournals.org.ccmain.ohionet.org/content/31/2/607.abstract
View in Article
Google Scholar
Jingwi EY
Abbas M
Ricks-Santi L
et al.
Vitamin D receptor genetic polymorphisms are associated with PSA level, gleason score and prostate cancer risk in african-american men.
Anticancer Res. 2015; 35 (Accessed October 12, 2020. /pmc/articles/PMC4743656/?report=abstract): 1549-1558
Circulating vitamin D, vitamin D-related genetic variation, and risk of fatal prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.
Cancer. 2015; 121: 1949-1956
https://doi.org/10.1002/cncr.29320
Influence of omega-6 PUFA arachidonic acid and bone marrow adipocytes on metastatic spread from prostate cancer.
Br J Cancer. 2010; 102: 403-413
https://doi.org/10.1038/sj.bjc.6605481
Glycemic index, glycemic load and cancer risk - ScienceDirect. Accessed July 30, 2020. https://www.sciencedirect.com/science/article/pii/S0923753419370346
Are strict vegetarians protected against prostate cancer?.
Am J Clin Nutr. 2016; 103: 153-160
https://doi.org/10.3945/ajcn.114.106450
The importance of the ratio of omega-6/omega-3 essential fatty acids.
Biomed Pharmacother. 2002; 56: 365-379
https://doi.org/10.1016/S0753-3322(02)00253-6
Characteristics of fats in Japanese diets and current recommendations. Lipids. 1996; 31: S283-S286 https://doi.org/10.1007/bf02637092
A high ratio of dietary n-6/n-3 polyunsaturated fatty acids is associated with increased risk of prostate cancer. Nutr Res. 2011; 31: 1-8
https://doi.org/10.1016/j.nutres.2011.01.002
Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomy. Cancer Prev Res. 2011; 4: 2062-2071 https://doi.org/10.1158/1940-6207.CAPR-11-0298
Effect of a low-fat fish oil diet on proinflammatory eicosanoids and cell-cycle progression score in men undergoing radical prostatectomy.
Cancer Prev Res. 2014; 7: 97-104
https://doi.org/10.1158/1940-6207.CAPR-13-0261
Curcumin inhibits Cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling.
Int J Oncol. 2015; 47: 2064-2072
https://doi.org/10.3892/ijo.2015.3202
Combination of α-Tomatine and Curcumin Inhibits Growth and Induces Apoptosis in Human Prostate Cancer Cells.
PLoS One. 2015; 10
https://doi.org/10.1371/journal.pone.0144293


Vitamin D and Omega-3 category starts with

394 Omega-3 items in category Omega-3 helps with: Autism (8 studies), Depression (29 studies), Cardiovascular (34 studies), Cognition (49 studies), Pregnancy (40 studies), Infant (32 studies), Obesity (13 studies), Mortality (7 studies), Breast Cancer (5 studies), Smoking, Sleep, Stroke, Longevity, Trauma (12 studies), Inflammation (18 studies), Multiple Sclerosis (9 studies), VIRUS (12 studies), etc
CIlck here for details


Items in both categories Prostate Cancer and Omega-3:



VitaminDWiki - Overview Prostate Cancer and Vitamin D contains:

All items in category Prostate Cancer and Vitamin D 101 items

Examples
The use of Vitamin D to prevent prostate cancer doubled in a decade – May 2019
Prostate cancer patients in Jamaica were 5X more likely to die of PC if low vitamin D - Sept 2022
Prostate Cancer – 300,000 annual deaths, low vitamin D is one of many factors – current status March 2015
No indication of association with Prostate Cancer and retinol, vitamin E or active vitamin D – Nov 2012
Can take 40,000 IU of vitamin D daily before prostate cancer surgery – RCT March 2013
The sun appears better at reducing incidence of some cancers than vitamin D – Dec 2012
The Meta-analysis of Prostate Cancer

Vitamin D prevents/treats Prostate Cancer much better when there is not excess Calcium
Prostate cancer risk increase with Vitamin D (other studies disagree) – meta-analysis Jan 2018 prevention
Prostate cancer reduced when 4000 IU vitamin D was added– Hollis RCT April 2015 treatment
7X increase in stage IV Prostate Cancer survival when vitamin D greater than 32 ng – May 2013
Never too late to have vitamin D - loading dose is great before Prostate Surgery


Vitamin D Receptor category has the following

510 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
- - - - - - - -
The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (21 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (16 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (36 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR


A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR


How to increase VDR activation


Compensate for poor VDR by increasing one or more:

IncreasingIncreases
1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
etc
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14)Butyrate especially gutVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
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Created by admin. Last Modification: Saturday March 16, 2024 15:44:51 GMT-0000 by admin. (Version 9)

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