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Preterm birth associated with many genes, including the Vitamin D Receptor again – Jan 2020

Transcriptome Analysis of Early Pregnancy Vitamin D Status and Spontaneous Preterm Birth

PLoS One, 15 (1), e0227193 2020 Jan 29 eCollection 2020, DOI: 10.1371/journal.pone.0227193
Aishwarya P Yadama 1, Hooman Mirzakhani 1, Thomas F McElrath 2, Augusto A Litonjua 3, Scott T Weiss 1

VitaminDWiki

Items in both categories Pregnancy and Vitamin D Receptor:


PRETERM was in the title of 78 VitaminDWiki pages as of Feb 2022
Vitamin D Receptor is associated in over 58 autoimmune studies
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor Activation can be increased by any of: Resveratrol,  Omega-3,  Magnesium, Zinc Quercetin,  non-daily Vit D.  Curcumin, intense exercise,  Ginger,  Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators



Reductions in Vitamin D is.gd/VitDReductions
click on chart for details

 Download the PDF from VitaminDWiki

Vitamin D Receptor is directly or indirectly connected to Spontaneous Preterm Birth genes

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Background: We conducted a literature review on the studies that investigated the relationship of preterm birth, including spontaneous preterm birth (sPTB), with vitamin D status. Overall, these studies demonstrated that the incidence of sPTB was associated with maternal vitamin D insufficiency in early pregnancy. However, the potential mechanisms and biological pathways are unknown.

Objectives: To investigate early pregnancy gene expression signatures associated with both vitamin D insufficiency and sPTB. We further constructed a network of these gene signatures and identified the common biological pathways involved.

Study design: We conducted peripheral blood transcriptome profiling at 10-18 weeks of gestation in a nested case-control cohort of 24 pregnant women who participated in the Vitamin D Antenatal Asthma Reduction Trial (VDAART). In this cohort, 8 women had spontaneous preterm delivery (21-32 weeks of gestation) and 17 women had vitamin D insufficiency (25-hydroxyvitamin D < 30 ng/mL). We separately identified vitamin D-associated and sPTB gene signatures at 10 to 18 weeks and replicated the overlapping signatures in the mid-pregnancy peripheral blood of an independent cohort with sPTB cases.

Result: At 10-18 weeks of gestation, 146 differentially expressed genes (25 upregulated) were associated with both vitamin D insufficiency and sPTB in the discovery cohort (FDR < 0.05). Of these genes, 43 (25 upregulated) were replicated in the independent cohort of sPTB cases and controls with normal pregnancies (P < 0.05). Functional enrichment and network analyses of the replicated gene signatures suggested several highly connected nodes related to inflammatory and immune responses.

Conclusions: Our gene expression study and network analyses suggest that the dysregulation of immune response pathways due to early pregnancy vitamin D insufficiency may contribute to the pathobiology of sPTB.


Created by admin. Last Modification: Sunday February 20, 2022 23:46:07 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
13423 PTB table.jpg admin 30 Jan, 2020 531.33 Kb 505
13422 PTB VDR.jpg admin 30 Jan, 2020 119.84 Kb 488
13421 Transcriptome PTB.pdf admin 30 Jan, 2020 1.45 Mb 526