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Premies with low Vitamin D are 14 percent more like to have expensive gut problems (necrotizing enterocolitis) – March 2017

Maternal/neonatal vitamin D deficiency: a new risk factor for necrotizing enterocolitis in preterm infants?

Journal of Perinatology , (23 March 2017) | doi:10.1038/jp.2017.18
M Cetinkaya, T Erener-Ercan, T Kalayci-Oral, A Babayiğit, B Cebeci, S Y Semerci and G Buyukkale

The objective of the study was to investigate the possible association between maternal/neonatal 25-hydroxy vitamin D (25-OHD) levels and development of necrotizing enterocolitis (NEC).

Study Design:
One hundred and forty-five preterm infants less than or equal to 36 weeks of gestation were enrolled. 25-OHD levels were determined in maternal/neonatal blood samples that were obtained at the time of admission to the neonatal intensive care unit.

Of the 145 enrolled patients, 26 (18%) developed NEC. Maternal/neonatal 25-OHD levels in the NEC group were significantly lower than those of the no-NEC group (P=0.001 and 0.004, respectively). In univariate logistic regression analysis, both maternal/neonatal vitamin D levels were a significant predictor of NEC (odds ratio (OR): 0.92 and 0.89; P<0.001 and P<0.005, respectively). However, multivariate logistic regression analysis revealed that only maternal vitamin D level was a significant predictor of NEC (OR: 0.86, P<0.0009).

This is the first study to propose a possible association between maternal/neonatal 25-OHD levels and subsequent development of NEC in preterm infants.

Publisher rents the PDF for $4

See also web

VitaminDWiki Calculation:
Vitamin D does not appear to be a cost-effective way to prevent NEC

  1. 1 in 1,000 live births get NEC (see web above)
  2. $100,000 = Conservative cost of NEC
    thus NEC only adds $100 to the average cost of birth
  3. 14% less NEC if high good level of vitamin D (study on this page)
    Thus adding Vitamin D would only reduce the averagecost of birth due to NEC by $14
    This calculation does not consider the decrease in extreme premie births by vitamin D
    This calculation does not consider adding Vitamin D to premie after birth but before NEC starts

See also VitaminDWiki

Healthy pregnancies need lots of vitamin D has the following summary

0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRandomized Controlled Trial
3. Gestational Diabetes 3 times Randomized Controlled Trial
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times Randomized Controlled Trial
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times Randomized Controlled Trial
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
Randomized Controlled Trial
10. Childhood Wheezing 1.3 times Randomized Controlled Trial
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRandomized Controlled Trial
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times Randomized Controlled Trial
16. Childhood Respiratory Tract visits 2.5 times Randomized Controlled Trial

Attached files

ID Name Comment Uploaded Size Downloads
7876 Necrotizing Enterocolitis Risk.pdf PDF admin 24 Mar, 2017 15:26 665.49 Kb 151
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