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Pregnancy Vitamin D levels less than 40 ng probably results in poor fetal tooth mineralization – March 2018

Foetal, neonatal and child vitamin D status and enamel hypomineralization

Community Dentistry and Oral Epidemiology 01 March 2018, https://doi.org/10.1111/cdoe.12372
Justin T. van der Tas Marlies E.C. Elfrink Annemieke C. Heijboer Fernando Rivadeneira Vincent W.V. Jaddoe Henning Tiemeier

VitaminDWiki
  • This study only considered Vitamin D Levels during pregnancy of slightly above 20 ng
  • Tooth mineralization is assumed to happen during pregnancy
  • The many benefits of vitamin D during pregnancy typically occur above 40 ng
  • It is rare to find a woman living much of her life indoors with no supplementation with even 30 ng of vitamin D
  • We anticipate that > 40 ng of Vitamin D during pregnancy will result in good tooth mineralization
  • > 40 ng of vitamin D is typical for women living outdoors a lot:
    • native Africans, gardeners, life guards
  • > 40 ng of vitamin D is also achieved by taking 6,400 IU of Vitamin D during pregnancy
    • Unfortunately current trials do not start adding vitamin D until the 10 week
    • And those trials do not get > 40 ng until weeks 18-22 (12th week if use loading doses)
    • Tooth development starts at 6 weeks
    • Need good Vitamin D level before mineralization – need to find out when that happens

See also VitaminDWiki

Healthy pregnancies need lots of vitamin D has the following summary

Problem
ReducesEvidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRandomized Controlled Trial
3. Gestational Diabetes 3 times Randomized Controlled Trial
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times Randomized Controlled Trial
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times Randomized Controlled Trial
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
Randomized Controlled Trial
10. Childhood Wheezing 1.3 times Randomized Controlled Trial
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRandomized Controlled Trial
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times Randomized Controlled Trial
16. Childhood Respiratory Tract visits 2.5 times Randomized Controlled Trial

 Download the PDF from VitaminDWiki
Image

Objectives
Recent literature suggested that higher vitamin D concentrations in childhood are associated with a lower prevalence of molar incisor hypomineralization (MIH). As tooth development already starts in utero, we aimed to study whether vitamin D status during foetal, postnatal and childhood periods is associated with the presence of hypomineralized second primary molars (HSPMs) and/or MIH at the age of six.

Methods
Our study was embedded in the Generation R Study, a population‐based, prospective cohort from foetal life onwards in Rotterdam, the Netherlands. HSPMs and MIH were scored from intraoral photographs of the children at their age of six. Serum 25(OH)D concentrations were measured at three points in time, which resulted in three different samples; mid‐gestational in mothers’ blood (n = 4750), in umbilical cord blood (n = 3406) and in children's blood at the age of 6 years (n = 3983).

Results
The children had a mean (±SD) age of 6.2 (±0.5) years at the moment of taking the intraoral photographs. After adjustment for confounders, no association was found between foetal 25(OH)D concentrations and the presence of HSPMs (OR 1.02 per 10 nmol/L higher 25(OH)D, 95% CI: 0.98‐1.07) or MIH (OR 1.05 per 10 nmol/L increase, 95% CI: 0.98‐1.12) in 6‐year‐olds. A higher 25(OH)D concentration in umbilical cord blood resulted in neither lower odds of having HSPM (OR 1.05, 95% CI: 0.98‐1.13) nor lower odds of having MIH (OR 0.95, 95% CI: 0.84‐1.07) by the age of six. Finally, we did not find higher 25(OH)D concentrations at the age of six to be associated with a significant change in the odds of having HSPM (OR 0.97, 95% CI: 0.92‐1.02) or MIH (OR 1.07, 95% CI: 0.98‐1.16).

Conclusions
25(OH)D concentrations in prenatal, early postnatal and later postnatal life are not associated with the presence of HPSMs or with MIH at the age of six. Future observational research is required to replicate our findings. Furthermore, it is encouraged to focus on identifying other modifiable risk factors, because prevention of hypomineralization is possible only if the causes are known.

Created by admin. Last Modification: Sunday May 20, 2018 02:09:36 UTC by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
9880 teeth 20 ng.jpg admin 20 May, 2018 01:12 77.38 Kb 35
9879 hypomineralization.pdf PDF 2018 admin 20 May, 2018 01:12 226.92 Kb 19
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