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Pregnancies starting with high vitamin D often have fewer toxic metals in 3rd trimester – June 2024


Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective

Curr Epidemiol Rep (2024). https://doi.org/10.1007/s40471-024-00348-0
Mandy Fisher, Hope A. Weiler, Jordan R. Kuiper, Michael Borghese, Jessie P. Buckley, Robin Shutt, Jillian Ashley-Martin, Anita Subramanian, Tye E. Arbuckle, Beth K. Potter, Julian Little, Anne-Sophie Morisset & Anne Marie Jukic

Purpose of Review
To discuss the potential biological mechanisms between vitamin D and toxic metals and summarize epidemiological studies examining this association in pregnant women.

Recent Findings
We identified four plausible mechanisms whereby vitamin D and toxic metals may interact: nephrotoxicity, intestinal absorption of metals, endocrine disruption, and oxidative stress. Few studies have examined the association between vitamin D and toxic metals in pregnant women. North American studies suggest that higher vitamin D status early in pregnancy are associated with lower blood metals later in pregnancy. However, a trial of vitamin D supplementation in a pregnant population, with higher metal exposures and lower overall nutritional status, does not corroborate these findings.

Summary
Given ubiquitous exposure to many toxic metals, nutritional intervention could be a means for prevention of adverse outcomes. Future prospective studies are needed to establish a causal relationship and clarify the directionality of vitamin D and metals.
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VitaminDWiki - Pregnancy category contains

901 items in Pregnancy category

 - see also


VitaminDWiki – Healthy pregnancies need lots of vitamin D contains

Problem
Vit. D
Reduces
Evidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
RCT
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

Attached files

ID Name Comment Uploaded Size Downloads
21382 Toxic Metals in Pregnancy_CompressPdf.pdf admin 29 Jun, 2024 233.57 Kb 15