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Predict 50nmol if take 600 IU of Vitamin D for 7 months (UK, ignoring BMI, etc) – June 2024


The pharmacokinetic differences between 10- and 15-μg daily vitamin D doses

Br J Clin Pharmacol. 2024 Jun 26. doi: 10.1111/bcp.16146
Tao You 1 2 3, Nadda Muhamad 1 2 4, Joseph Jenner 1, Zhonghui Huang 3 5

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Aims: The reference nutrient intake for vitamin D in people aged ≥4 years is 10 μg/day (400 IU/day) in the UK, but the recommended daily allowance is 15 μg/day (600 IU/day) for people aged 1-70 years in the USA. Here, we aim to compare the 25-hydroxyvitamin D (25(OH)D) serum concentration profiles between the 2 doses.

Methods: With world-wide trial data of adults aged ≥18 years, 45-93 kg, we constructed a minimal physiologically based pharmacokinetics model of serum concentrations of vitamin D and 25(OH)D using nonlinear mixed effects modelling. We used this model to forecast the mean, 2.5th and 97.5th percentiles for serum 25(OH)D concentrations in British adults aged ≥16 years.

Results: Our final model used bodyweight to adjust volume of each compartment and maximum clearance of 25(OH)D. No other covariate was identified. The model accurately predicted independent data from trials of a broad range of dosing regimens. We simulated British adults and showed that circulating 25(OH)D concentrations in 95% of people taking 10 μg/day for a year is predicted to reach 50 nmol/L in 32 weeks, while 97.5% of those on 15 μg/day were predicted to attain this threshold within 28 weeks.

Conclusion: Both doses are efficacious in >95% of the British population. The daily dose of 15 μg can help 97.5% of the British adults achieve 50 nmol/L serum 25(OH)D and reach the 25 nmol/L threshold in 4 weeks.
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Attached files

ID Name Comment Uploaded Size Downloads
21376 UK 600 IU.webp admin 27 Jun, 2024 15.18 Kb 34
21375 UK 600 IU get to 20 ng_CompressPdf.pdf admin 27 Jun, 2024 1.46 Mb 5