Prediabetes Patients Have Fewer Gut Bugs MedPageToday
News Release for Endocrinology Conference
Significant Differences in Fecal Microbiota Are Associated with Various Stages of Glucose Tolerance in African-American Male Veterans
African American men divided into 4 groups
- stable glucose tolerance,
- stable impaired fasting glucose
or stable impaired glucose tolerance,
- worsened glucose tolerance
- improved glucose tolerance.
There were significant differences in bacterial composition between the first and second groups (P=0.03) at the phylum level. Bacteroidetes was higher and Firmicutes was lower with worse glycemic control in the second group.
The Bacteroidetes/Firmicutes ratio was 1.9 versus 0.9 in group 1 and 2 (P=0.01) and 1.9 versus 1.1 in group 1 and 3 (P=0.04).
Proteobacteria decreased over the period in groups 2 and 4 compared to group 1 (P=0.04 for both).
At the family and genus levels, in group 2 versus group 1 there was less Prevotella, and a higher Bacteroides/Prevotella ratio in the second group at 5.6 to 2.7 (P=0.05). There was also less Enterobacteriacea (P=0.03), and more Ruminococcae (P=0.01) and Veillonelacea (P=0.02).
"We speculate that lower abundance of Prevotella may be associated with worsening glycemia, and conversely higher abundance of Akkermansia might be associated with improving glycemia, thus corroborating suggestions from previous studies,"
- Antibiotics, probiotics category listing has
80 items along with related searches
- Antibiotics and Vitamin D are associated with many of the same diseases
- Exploring gut microbes in Human health and disease: pushing the envelope - Aug 2014
Items in both categories Antibiotics/Probiotics and Diabetes are listed here:
Prediabetic have very different gut bacteria – March 2015
- Prediabetics had different gut bacteria – April 2018
- Vitamin D treatment of diabetes (50,000 IU every 2 weeks) augmented by probiotic – RCT June 2018
- 5 Antibiotic courses raised risk of diabetes by 37 percent (200,000 diabetics, more than 1 year after antibiotic) - 2015, 2016
- Diabetes risk increased by 50 percent if had 5 courses of antibiotics – Aug 2015
- Prediabetic have very different gut bacteria – March 2015
- Hypothesis: vitamin D and probiotics will reduce type II diabetes – Jan 2013
3026 visitors, last modified 29 Jun, 2018,