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Post menopausal vaginal dryness treated with vitamin D vaginal suppositories – RCT March 2015

The effect of vitamin D on vaginal atrophy in postmenopausal women

Iranian Journal of Nursing and MidWifery Research Vol 20, No 2 (2015)
Parastou Rad, Mitra Tadayon, Mohammadreza Abbaspour, Seyed Mahmood Latifi, Iran Rashidi, Hamdollah Delaviz

VitaminDWiki Summary

44 women in 8 week Random Controlled Trial
Vaginal suppositories: 1000 IU vitamin D or placebo
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See also VitaminDWiki
Overview Women and Vitamin D
ALL of the top 10 health problems of women are associated with low vitamin D
Vaginal Vitamin D reduced vaginal infections - Jan 2014
Overview Skin and vitamin D
Topical Vitamin D

Suspect topical Vitamin D drops, creams would work just as well in vagina
Suspect more than 1,000 IU would be much better
Many Vitamin D drops available on Amazon >400 as of April 2015, etc.
A variety of Vitamin D creams are also available on Amazon
See also web
The effect of vitamin D suppository on atrophic vaginal mucosa in menopausal women
    Some of the same authors, May 2015, no abstract USD 36


Background: Most of the women suffer from vaginal atrophy and dryness, and therefore, efficient and safe treatment is needed to improve vaginal lubrication. Vitamin D has several important functions which may be effective in proliferation and repair of the epithelial tissue. This study aimed to evaluate the effect of vitamin D vaginal suppositories on maturation index, pH, and dryness in postmenopausal women.

Materials and Methods: Women were enrolled in this double-blind clinical trial, in whom menopause occurred at least one year ago. Those women who had an abnormal Papanicolaou smear, had undergone hormonal treatment, or have had vaginal infection in the previous year were excluded. Forty-four women who found eligible were randomized into two equal groups, the treatment and control groups, which received vitamin D and placebo vaginal suppository daily for 8 weeks, respectively. Vaginal pH and maturation value were measured at the beginning and end of the study. Pain, dryness, and paleness were assessed before treatment and at the end of the 2, 4, and 8 weeks of treatment.

Results: In the treatment group, the

  • number (Mean ± SD) of superficial cells increased (69.76 ± 12.4) and
  • vaginal pH decreased (1.42 ± 0.67) significantly compared to the control group after 56 days.

The mean pain significantly reduced after 8 weeks in the

  • treatment group (1.23 ± 0.53) compared to the
  • control group 1.95 ± 0.74 (P < 0.001).

The mean of dryness and paleness reduced significantly in the treatment group versus control at 56 days.

Conclusions: Vitamin D is effective in improving the maturation index and decreased the pH and dryness of the vaginal atrophy due to menopause.

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Attached files

ID Name Comment Uploaded Size Downloads
5322 Vaginal atrophy.jpg admin 16 Apr, 2015 12:14 100.40 Kb 7414
5321 vaginal atrophy.pdf PDF 2015 admin 16 Apr, 2015 12:11 634.54 Kb 556
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