Genetic Variation of the Vitamin D Binding Protein Affects Vitamin D Status and Response to Supplementation in Infants
J Clin Endocrinol Metab . 2019 Nov 1;104(11):5483-5498. doi: 10.1210/jc.2019-00630.
Maria Enlund-Cerullo 1 2 3, Laura Koljonen 2 3, Elisa Holmlund-Suila 1 3, Helena Hauta-Alus 1 3, Jenni Rosendahl 1 3, Saara Valkama 1 3, Otto Helve 1, Timo Hytinantti 1, Heli Viljakainen 2 4, Sture Andersson 1, Outi Mäkitie 1 2 3 5, Minna Pekkinen 1 2 3
Infants were given 1200 IU daily for 2 years
Note: 1200 IU is a lot for a newborn, but not much for a 2 year old
Vitamin D Binding Protein category listing has 176 items and the following introduction
Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral Vitamin D
Vitamin D Binding Protein has a list of health problems
Increased
Risk Health Problem
11 X Preeclampsia
6.5X T1D in SA Blacks
6 X Food Allergy
5 X PTSD
4 X, 5X Kidney Cancer
4 X Poor Response to Oral Vitamin D
3 X Ear infection
2.8 X MS
2 X Colorectal Cancer
2 X Prostate Cancer -in those with dark skins
1.3 X Infertility
Genetics category listing contains the following
332 articles in the Genetics category
see also
- Vitamin D Receptor has
513 items
- Vitamin D Binding Protein = GC has
176 items
- CYP27B1 has
60 items
- CYP24A1 in title of 34+ items
- CYP2R1 25+ items
- Calcidiol has
46 items
- Calcitriol has
56 items
- Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
- CYP3A4 (7 as of Dec 2022)
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication) Commercially available 2019
- However, test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family
especially if it is one of 51+ diseases related to Vitamin D Receptor
+2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
+3) DNA and VDR tests - 120 to 200 dollars $100 to $250
+4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
Genes are good, have enough Magnesium, etc.
+4) Back Pain
probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of VitaminDWiki took action with clues #3&4
Download the PDF from VitaminDWiki
Context: Single nucleotide polymorphisms (SNPs) of the vitamin D binding protein encoding the GC (group component) gene affect 25-hydroxyvitamin D (25OHD) concentrations, but their influence on vitamin D status and response to vitamin D supplementation in infants is unknown.
Objective: To study GC genotype-related differences in 25OHD concentrations and the response to supplementation during a vitamin D intervention study in infants.
Design: In this randomized controlled trial, healthy term infants received vitamin D3 (10 or 30 μg/d) from 2 weeks to 24 months of age. GC SNPs rs2282679, rs4588, rs7041, and rs1155563 were genotyped. rs4588/7041 diplotype and haplotypes of rs2282679, rs4588, and rs7041 (Haplo3SNP) and of all four SNPs (Haplo4SNP) were determined.
Main outcome measures: 25OHD measured in cord blood at birth and at 12 and 24 months during intervention.
Results: A total of 913 infants were included. Minor allele homozygosity of all studied GC SNPs, their combined haplotypes, and rs4588/rs7041 diplotype 2/2 were associated with lower 25OHD concentrations at all time points in one or both intervention groups [analysis of covariance (ANCOVA) P < 0.043], with the exception of rs7041, which did not affect 25OHD at birth. In the high-dose supplementation group receiving 30 μg/d vitamin D3, but not in those receiving 10 µg/d, genotype of rs2282679, rs4588, and rs7041; diplotype; and Haplo3SNP significantly affected intervention response (repeated measurement ANCOVA Pinteraction < 0.019). Minor allele homozygotes had lower 25OHD concentrations and smaller increases in 25OHD throughout the intervention.
Conclusions: In infants, vitamin D binding protein genotype affects 25OHD concentration and efficiency of high-dose vitamin D3 supplementation.
Trial registration: ClinicalTrials.gov NCT01723852.
Poor protein binding gene associated with poor Vitamin D response – RCT Nov 2019
2707 visitors, last modified 02 Mar, 2021,
Printer Friendly
Follow this page for updates
This page is in the following categories (# of items in each category)
Attached files
ID
Name
Uploaded
Size
Downloads
15153
Response to 1200 IU.jpg
admin 02 Mar, 2021
96.08 Kb
291
15152
Genetic Variation in VDBP and response.pdf
admin 02 Mar, 2021
734.28 Kb
323
Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral Vitamin D
Vitamin D Binding Protein has a list of health problems
| Increased Risk | Health Problem |
| 11 X | Preeclampsia |
| 6.5X | T1D in SA Blacks |
| 6 X | Food Allergy |
| 5 X | PTSD |
| 4 X, 5X | Kidney Cancer |
| 4 X | Poor Response to Oral Vitamin D |
| 3 X | Ear infection |
| 2.8 X | MS |
| 2 X | Colorectal Cancer |
| 2 X | Prostate Cancer -in those with dark skins |
| 1.3 X | Infertility |
Genetics category listing contains the following
see also
- Vitamin D Receptor has
513 items - Vitamin D Binding Protein = GC has
176 items - CYP27B1 has
60 items - CYP24A1 in title of 34+ items
- CYP2R1 25+ items
- Calcidiol has
46 items - Calcitriol has
56 items - Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
- CYP3A4 (7 as of Dec 2022)
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication) Commercially available 2019
- However, test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family
especially if it is one of 51+ diseases related to Vitamin D Receptor
+2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase) +3) DNA and VDR tests - 120 to 200 dollars $100 to $250 +4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)Genes are good, have enough Magnesium, etc.
+4) Back Painprobably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of VitaminDWiki took action with clues #3&4
Download the PDF from VitaminDWiki
Context: Single nucleotide polymorphisms (SNPs) of the vitamin D binding protein encoding the GC (group component) gene affect 25-hydroxyvitamin D (25OHD) concentrations, but their influence on vitamin D status and response to vitamin D supplementation in infants is unknown.
Objective: To study GC genotype-related differences in 25OHD concentrations and the response to supplementation during a vitamin D intervention study in infants.
Design: In this randomized controlled trial, healthy term infants received vitamin D3 (10 or 30 μg/d) from 2 weeks to 24 months of age. GC SNPs rs2282679, rs4588, rs7041, and rs1155563 were genotyped. rs4588/7041 diplotype and haplotypes of rs2282679, rs4588, and rs7041 (Haplo3SNP) and of all four SNPs (Haplo4SNP) were determined.
Main outcome measures: 25OHD measured in cord blood at birth and at 12 and 24 months during intervention.
Results: A total of 913 infants were included. Minor allele homozygosity of all studied GC SNPs, their combined haplotypes, and rs4588/rs7041 diplotype 2/2 were associated with lower 25OHD concentrations at all time points in one or both intervention groups [analysis of covariance (ANCOVA) P < 0.043], with the exception of rs7041, which did not affect 25OHD at birth. In the high-dose supplementation group receiving 30 μg/d vitamin D3, but not in those receiving 10 µg/d, genotype of rs2282679, rs4588, and rs7041; diplotype; and Haplo3SNP significantly affected intervention response (repeated measurement ANCOVA Pinteraction < 0.019). Minor allele homozygotes had lower 25OHD concentrations and smaller increases in 25OHD throughout the intervention.
Conclusions: In infants, vitamin D binding protein genotype affects 25OHD concentration and efficiency of high-dose vitamin D3 supplementation.
Trial registration: ClinicalTrials.gov NCT01723852.
Poor protein binding gene associated with poor Vitamin D response – RCT Nov 2019Printer Friendly Follow this page for updates2707 visitors, last modified 02 Mar, 2021, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 15153 Response to 1200 IU.jpg admin 02 Mar, 2021 96.08 Kb 291 15152 Genetic Variation in VDBP and response.pdf admin 02 Mar, 2021 734.28 Kb 323 - Vitamin D Binding Protein = GC has