Poor chemotherapy results if low vitamin D (leukemia in this case) – May 2022

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Preinduction Serum Vitamin D3 Levels and Induction Chemotherapy Remission Rates in Patients with Acute Leukemia

Nutrition and Cancer – https://doi.org/10.1080/01635581.2022.2077389 PDF behind paywall
Shweta Maurya. Anil Kumar Tripathi, Shailendra Prasad Verma

Vitamin D deficiency(<20 ng/mL) is a common condition, associated with an inferior prognosis in some cancers. However, the prognostic significance of vitamin D deficiency in acute leukemia is largely unknown. The present study aimed to assess the baseline status of vitamin D [25-(OH) D3] and find its association with induction remission rate and mortality using standard chemotherapy in patients with acute leukemia. In this prospective observational study, blood samples were collected from 73 newly diagnosed patients before starting induction chemotherapy to measure serum vitamin D [25(OH)D] levels along with routine investigations.44/73 (60.3%) patients were acute lymphoblastic leukemia (ALL), and 29/77 (39.7%) were acute myeloid leukemia (AML) patients. Descriptive statistics and frequency distribution were used in SPSS software, and Pearson’s chi-squared test compared the categorical variables. Post-induction remission status (complete and incomplete remission) and induction-related mortality were correlated with vitamin D levels. 44/73 patients (60.3%) included in this study were males, and the remaining were females. The mean age of the participants was 30.32 ± 14.95 years. The mean serum vitamin D level in the cohort was 15.74 ± 28.14 ng/mL. Vitamin D deficiency was observed in 59/73 (80.8%) patients, whereas 14/73 (19.2%) had normal levels (≥20ng/mL) of the vitamin. Vitamin D deficiency is common among acute leukemia patients. Herein, we observed that low vitamin D level is associated with higher rates of incomplete remission in acute leukemia patients (P = 0.016). Vitamin D deficiency is common among acute leukemia patients and is associated with poor short-term outcomes.

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VitaminDWiki pages with CHEMOTHERAPY in title (27 as of Aug 2022)

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VitaminDWiki pages with CHEMO in title (10 as of Aug 2022)

This list is automatically updated

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See also in VitaminDWiki

Overview Leukemia and Vitamin D

• Vitamin D is synergistic with many Cancer therapies (radiation in this case) – Aug 2021
• Vitamin D prevents and treats cancer in many ways – May 2021
• Breast cancer recurred twice as often if have less than 20 ng of vitamin D – Dec 2018
• Cancer patients need more vitamin D, even those who are supplementing – observational study June 2021

Chemotherapy might be amplified by vitamin D
Increased Vitamin D might allow decreased Chemotherapy
Chart by VitaminDWiki

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Warning: Vitamin D can increase Chemo potency - possible death if chemo dose is not reduced