Efficacy of vitamin D supplementation according to vitamin D-binding protein polymorphisms.
Nutrition. 2019 Feb 19;63-64:148-154. doi: 10.1016/j.nut.2019.02.003.
Al-Daghri NM1, Mohammed AK2, Bukhari I3, Rikli M4, Abdi S5, Ansari MGA5, Sabico S5, Hussain SD5, Alenad A6, Al-Saleh Y4, Alokail MS6.
Poor response = < 20 ng after 8 weeks of 50,000 IU Vitmin D weekly
Poor response due to poor VDRP has been documented in many studies
- Vitamin D Nutrigenomics - High, Medium, and Low Responders - March 2019
- Decreased response to vitamin D in white children having poor Vitamin D binding gene – Feb 2019
- Response to Vitamin D varies with Vitamin D Binding Protein gene – RCT May 2018
- 10 reasons for poor response to Vitamin D (race, binding protein, etc.) – Nov 2017
Vitamin D Binding Protein category listing has 176 items has the following
Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral Vitamin D
Genetics category listing contains the following
332 articles in the Genetics category
see also
- Vitamin D Receptor has
512 items
- Vitamin D Binding Protein = GC has
176 items
- CYP27B1 has
60 items
- CYP24A1 in title of 34+ items
- CYP2R1 25+ items
- Calcidiol has
46 items
- Calcitriol has
56 items
- Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
- CYP3A4 (7 as of Dec 2022)
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication) Commercially available 2019
- However, test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family
especially if it is one of 51+ diseases related to Vitamin D Receptor
+2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
+3) DNA and VDR tests - 120 to 200 dollars $100 to $250
+4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
Genes are good, have enough Magnesium, etc.
+4) Back Pain
probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of VitaminDWiki took action with clues #3&4
See also web
- Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions - May 2019 doi: 10.3389/fendo.2019.00317 Free PDF
Download the PDF from VitaminDWiki
RS4588
OBJECTIVES: The aim of this study was to determine the influence of vitamin D-binding protein (DBP) gene polymorphisms in vitamin D metabolites before and after vitamin D supplementation.
METHODS: In all, 234 participants (126 women; 108 men) with vitamin D deficiency [25(OH)D <50 nmol/L] were given 50 000 IU of vitamin D supplements for 8 wk followed by daily maintenance of 1000 IU for 4 mo. Two single-nucleotide polymorphisms (rs4588 and rs7041) in DBP coding gene were assessed.
RESULTS: Baseline 25(OH)D was significantly in higher in participants with homozygous major genotype of rs7041 than other genotypes (P = 0.02). Post supplementation 25(OH)D was significantly higher in participants with homozygous major genotypes of either rs4588 and rs7041 than other genotypes (P < 0.001).
Participants with the minor allele of either rs4588 or rs7041 were 2.9 (1.9-4.5) times and 3.7 (2.1-6.6) times, respectively, more likely to be non-responders (post supplementation 25 OHD <50 nmol/L) than those homozygous for the major allele at these locations (P < 0.001).
Furthermore, participants with homozygous minor and heterozygous genotype of rs7041 were 6.2 and 4.2 times more likely to be non-responders than those with the homozygous major genotype (P < 0.001) even after adjustments for age, sex, body mass index, baseline 25(OH)D concentration, and other alleles.
Participants with homozygous minor and heterozygous genotypes of rs4588 were 4.1 and 12.4 times more likely to be non-responders than those with homozygous major genotypes. These significant risks, however, were lost after adjustment.
CONCLUSIONS: rs7041 and rs4588 variants of the DBP gene are associated with variations in 25(OH)D levels and efficacy of response to vitamin D supplementation in Saudi Arabian adults.
Poor Vitamin D response 4X more likely if poor Vitamin D binding proteins - July 2019
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T5 VDBP.jpg
admin 09 Apr, 2019
54.57 Kb
560
11731
non-responders.jpg
admin 09 Apr, 2019
12.01 Kb
512
11730
vitamin D-binding protein polymorphisms.pdf
admin 09 Apr, 2019
550.15 Kb
584
Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral Vitamin D
Genetics category listing contains the following
see also
- Vitamin D Receptor has
512 items - Vitamin D Binding Protein = GC has
176 items - CYP27B1 has
60 items - CYP24A1 in title of 34+ items
- CYP2R1 25+ items
- Calcidiol has
46 items - Calcitriol has
56 items - Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
- CYP3A4 (7 as of Dec 2022)
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication) Commercially available 2019
- However, test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family
especially if it is one of 51+ diseases related to Vitamin D Receptor
+2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase) +3) DNA and VDR tests - 120 to 200 dollars $100 to $250 +4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)Genes are good, have enough Magnesium, etc.
+4) Back Painprobably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of VitaminDWiki took action with clues #3&4
See also web
- Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions - May 2019 doi: 10.3389/fendo.2019.00317 Free PDF
Download the PDF from VitaminDWiki
RS4588
OBJECTIVES: The aim of this study was to determine the influence of vitamin D-binding protein (DBP) gene polymorphisms in vitamin D metabolites before and after vitamin D supplementation.
METHODS: In all, 234 participants (126 women; 108 men) with vitamin D deficiency [25(OH)D <50 nmol/L] were given 50 000 IU of vitamin D supplements for 8 wk followed by daily maintenance of 1000 IU for 4 mo. Two single-nucleotide polymorphisms (rs4588 and rs7041) in DBP coding gene were assessed.
RESULTS: Baseline 25(OH)D was significantly in higher in participants with homozygous major genotype of rs7041 than other genotypes (P = 0.02). Post supplementation 25(OH)D was significantly higher in participants with homozygous major genotypes of either rs4588 and rs7041 than other genotypes (P < 0.001).
Participants with the minor allele of either rs4588 or rs7041 were 2.9 (1.9-4.5) times and 3.7 (2.1-6.6) times, respectively, more likely to be non-responders (post supplementation 25 OHD <50 nmol/L) than those homozygous for the major allele at these locations (P < 0.001).Furthermore, participants with homozygous minor and heterozygous genotype of rs7041 were 6.2 and 4.2 times more likely to be non-responders than those with the homozygous major genotype (P < 0.001) even after adjustments for age, sex, body mass index, baseline 25(OH)D concentration, and other alleles.
Participants with homozygous minor and heterozygous genotypes of rs4588 were 4.1 and 12.4 times more likely to be non-responders than those with homozygous major genotypes. These significant risks, however, were lost after adjustment.CONCLUSIONS: rs7041 and rs4588 variants of the DBP gene are associated with variations in 25(OH)D levels and efficacy of response to vitamin D supplementation in Saudi Arabian adults.
Poor Vitamin D response 4X more likely if poor Vitamin D binding proteins - July 2019Printer Friendly Follow this page for updates3669 visitors, last modified 15 Jun, 2019, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 11733 T5 VDBP.jpg admin 09 Apr, 2019 54.57 Kb 560 11731 non-responders.jpg admin 09 Apr, 2019 12.01 Kb 512 11730 vitamin D-binding protein polymorphisms.pdf admin 09 Apr, 2019 550.15 Kb 584 - Vitamin D Binding Protein = GC has