Neurodegener Dis. 2016;16(3-4):199-205. doi: 10.1159/000441917. Epub 2016 Jan 7.
Kwon KY1, Jo KD, Lee MK, Oh M, Kim EN, Park J, Kim JS, Youn J, Oh E, Kim HT, Oh MY, Jang W.
14 seconds No PD
19 seconds PD, not low vitamin D
33 seconds PD and associated with low Vitamin D
- Wonder if poop-time is also increased for those with low D but without PD?
- Note: The most constipation I have had in my life occured when I was taking lots of vitamin D but had not yet added Magnesium
BACKGROUND AND OBJECTIVES:
Gastrointestinal dysfunction is a common non motor symptom in Parkinson's disease (PD). However, the potential association between vitamin D and gastroparesis in PD has not been previously investigated. The aim of this study was to compare vitamin D levels between drug-naive de novo PD patients with normal gastric emptying and those with delayed gastric emptying.
Fifty-one patients with drug-naive de novo PD and 20 age-matched healthy controls were enrolled in this study. Gastric emptying time (GET) was assessed by scintigraphy, and gastric emptying half-time (T1/2) was determined. The PD patients were divided into a delayed-GET group and a normal-GET group.
The serum 25-hydroxyvitamin D3 levels were decreased in the delayed-GET group compared with the normal-GET and control groups (11.59 ± 4.90 vs. 19.43 ± 6.91 and 32.69 ± 4.93, respectively, p < 0.01). In the multivariate model, the serum 25-hydroxyvitamin D3 level was independently associated with delayed gastric emptying in PD patients.
Vitamin D status may be an independent factor for gastric dysmotility in PD. Although the underlying mechanism remains to be characterized, vitamin D status may play a role in the pathogenesis of delayed gastric emptying in drug-naive PD.
PMID: 26735311 DOI: 10.1159/000441917
PDF is behind a publisher paywall
- Gastric motor dysfunctions in Parkinson's disease: Current pre-clinical evidence Dec 2015
PDF available at deepdyve.com The word vitamin does not appear once in the PDF