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Pesticides 8 X more likely to result in female infertility if low vitamin D – Sept 2023

Vitamin D Intake Attenuated the Association between Pesticides Exposure and Female Infertility

Clin Lab. 2023 Sep 1;69(9). doi: 10.7754/Clin.Lab.2023.230201.
Chunxiu Wu, Xiaoqin Xin, Jianlan Chen

Background: Only a few epidemiological studies have illuminated the association between pesticide exposure and female infertility. However, evidence of the available data is restricted and also controversial. Vitamin D supplement was considered as having a beneficial effect on fertility. So, the purpose of our study is to assess the effect of dietary vitamin D consumption on the relationship between pesticide exposure in home and female infertility.

Methods: There were a total of 2,968 subjects from the National Health and Nutrition Examination Survey (NHANES), 2011 - 2018. The daily vitamin D intake was divided into two groups high intake (≥ 6 µg/d) and low intake (< 6 µg/d). Multi-variable logistic regression analysis was used to assess the relationship among vitamin D intake, pesticide exposure, and female infertility.

Results: We found a significant association between household pesticide exposure and infertility on a basis of a fully-adjusted model (OR 1.61; 95% CI 1.1 - 2.37). Furthermore, the relationship between pesticide exposure and in-fertility differed from low vitamin D intake group (OR 3.96; 95% CI 1.77 - 8.86) and high intake group (OR 1.36, 95% CI: 0.86 - 2.16), and p for interaction is 0.043 stratified by vitamin D intake.

Conclusions: A significant association of female infertility with pesticide exposure in home is modified by dietary vitamin D consumption. This was the first study to demonstrate that dietary vitamin D may alter associations of human female infertility with pesticide exposure in home.

8 X = (3.96 -1) / (1.36 -1) Note: Low D = <240 IU daily

4 Other pesticide and Vitamin D studies in VitaminDWiki

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google Scholar as of Sept 2023

  • Associations between Organochlorine Pesticides and Vitamin D Deficiency in the U.S. Population - Jan, 2012 https://doi.org/10.1371/journal.pone.0030093 FREE PDF
  • The effect of chronic vitamin deficiency and long term very low dose exposure to 6 pesticides mixture on neurological outcomes – A real-life risk simulation approach - Oct 2019 https://doi.org/10.1016/j.toxlet.2019.07.026 can probably get PDF from Sci-Hub
  • Detrimental effects of 6 months exposure to very low doses of a mixture of six pesticides associated with chronic vitamin deficiency on rats - June 2021 https://doi.org/10.1016/j.fct.2021.112188
    • Very low = 100 times lower than NOAEL. up-regulated genes CYP1A1, CYP1A2, CYP2B1 and GST level
  • Autism Spectrum Disorder and Prenatal or Early Life Exposure to Pesticides: A Short Review - Oct 2021 https://doi.org/10.3390/ijerph182010991 FREE PDF
    • "Conclusions: Among the different environmental pollutants, pesticides should be considered as emerging risk factors for ASD."