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People with nonalcoholic fatty liver disease and low vitamin D have increased high risk of advanced liver fibrosis – Feb 2017


Low vitamin D status is associated with advanced liver fibrosis in patients with nonalcoholic fatty liver disease - Feb 2017

Endocrine. 2017 Feb;55(2):582-590. doi: 10.1007/s12020-016-1152-x. Epub 2016 Oct 31.
Yang BB1, Chen YH2,3, Zhang C2, Shi CE1, Hu KF1, Zhou J1, Xu DX4, Chen X5.

VitaminDWiki Summary

It appears that as there is more fibrosis the liver does not semi-acitive vitamin D as well

See also VitaminDWiki

Overview Liver and vitamin D contains the following summary

  • Fact: A properly functioning liver is needed for the efficient activation of vitamin D in the body
  • Fact: Liver diseases often result in lower levels of vitamin D
  • Fact: Various pain relievers damage the liver function
  • Fact: Lower levels of vitamin D result in osteoporosis and many other diseases
  • Options with a poorly functioning liver appear to be:
  1. Increased vitamin D (example: 2X more vitamin D if Liver is 1/2 as efficient)
  2. Increase the response you get from vitamin D
  3. Increase sunshine / UVB,
  4. Get the response you get from the sun/UVB
  5. Consider supplementing with Iron - a patented Iron supplement appears to work very well
  6. Get prescription for active form of vitamin D (Calcitriol) which does not need the liver or kidney to get the benefits of vitamin D in the body
  7. Get Calcidiol which does not need the liver
  8. Use Topical Vitamin D - activation by the skin etc does not require the liver

http://vitamindwiki.com/tiki-index.php?page_id=5644
Click on image for ways of getting vitamin D even if Liver is not functioning well


 Download the PDF from SciHub via VitaminDWiki
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Several studies explored the association between vitamin D status and nonalcoholic fatty liver disease with contradictory results. We aimed to investigate the association between vitamin D status, inflammatory cytokines and liver fibrosis in nonalcoholic fatty liver disease patients. Two hundred nineteen nonalcoholic fatty liver disease patients and 166 age- and gender- matched healthy controls were recruited for this study. Serum 25(OH)D was measured by radioimmunoassay. Serum interleukin-8 and transforming growth factor-β1 were measured using ELISA. Serum 25(OH)D was only marginally decreased in nonalcoholic fatty liver disease patients. Interestingly, serum 25(OH)D was markedly reduced in nonalcoholic fatty liver disease patients with advanced liver fibrosis compared to nonalcoholic fatty liver disease patients with indeterminate liver fibrosis and no advanced fibrosis. Logistic regression analysis showed that there was an inverse association between serum 25(OH)D and severity of liver fibrosis in nonalcoholic fatty liver disease patients. Further analysis showed that serum interleukin-8 was elevated in nonalcoholic fatty liver disease patients, the highest interleukin-8 in patients with advanced fibrosis. An inverse correlation between serum 25(OH)D and interleukin-8 was observed in nonalcoholic fatty liver disease patients with and without liver fibrosis. Although serum transforming growth factor-β1 was slightly elevated in nonalcoholic fatty liver disease patients, serum transforming growth factor-β1 was reduced in nonalcoholic fatty liver disease patients with advanced fibrosis. Unexpectedly, a positive correlation between serum 25(OH)D and transforming growth factor-β1 was observed in nonalcoholic fatty liver disease patients with advanced fibrosis. In conclusion, low vitamin D status is associated with advanced liver fibrosis in nonalcoholic fatty liver disease patients. Interleukin-8 may be an important mediator for hepatic fibrosis in nonalcoholic fatty liver disease patients with low vitamin D status.

PMID: 27796814 DOI: 10.1007/s12020-016-1152-x


Low vitamin D does not cause NAFLD - Feb 2018

Vitamin D and Nonalcoholic Fatty Liver Disease: Bi-directional Mendelian Randomization Analysis

Results
An SD increase in the 25(OH)D GRS was significantly associated with 25(OH)D (β 1.29, 95%CI − 1.54, − 1.04, P < 0.05) but not with NAFLD (OR 0.97, 95%CI 0.92, 1.01). An SD increase in NAFLD GRS was also strongly associated with NAFLD (OR 1.09, 95%CI 1.04, 1.15, P < 0.05) but not with 25(OH)D (β − 0.15, 95%CI − 0.41, 0.10). Using an instrumental variable estimator, no associations were found for genetically instrumented 25(OH)D with NAFLD and for genetically instrumented NAFLD with 25(OH)D.
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Created by admin. Last Modification: Tuesday January 9, 2018 15:22:29 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
9153 Mendelian NAFLD.pdf PDF 2018 admin 09 Jan, 2018 15:19 695.65 Kb 368
8221 NAFLD F2A.jpg admin 27 Jul, 2017 15:10 16.69 Kb 418
8220 NAFLD F2B.jpg admin 27 Jul, 2017 15:09 16.08 Kb 457
8219 NSFLD T3B.jpg admin 27 Jul, 2017 15:09 14.45 Kb 488
8218 NAFLD T3C.jpg admin 27 Jul, 2017 15:09 15.54 Kb 470
8217 FLD with low vitamin D associated ith liver fibrosis.pdf PDF 2017 admin 27 Jul, 2017 15:08 800.30 Kb 671
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