Horm Metab Res : DOI: 10.1055/s-0030-1268485
S. Devaraj1, G. Jialal1, T. Cook1, D. Siegel1,2, I. Jialal1,2
1 Department of Pathology and Laboratory Medicine, University of California, Davis, Medical Center, Sacramento, CA, USA
2 Veterans Affairs Medical Center, Mather, CA, USA
Metabolic syndrome (MetS), is a constellation of cardiometabolic disease risk factors, that affects 1 in 3 US adults and predisposes to increased risks for both diabetes and cardiovascular disease. While epidemiological studies show low vitamin D (25(OH)D levels in MetS, there is sparse data on vitamin D status in MetS patients in North America. Thus, the aim of our study was to examine plasma vitamin D concentration among adults with MetS in Northern California (sunny climate), but without diabetes or cardiovascular disease. 25(OH)D levels were significantly decreased in MetS compared to controls. 8% of controls and 30% of MetS North American adult subjects were deficient in 25(OH)D (<20 ng/ml; p=0.0236, Controls vs. MetS). There were no significant differences between the groups with respect to blood sampling in winter and summer months, total calcium and phosphate, and creatinine levels. Vitamin D levels were significantly inversely correlated with fasting glucose (r=?0.29, p=0.04) and HOMA (r=?0.34, p=0.04). Future studies of vitamin D supplementation in these subjects on subsequent risk of diabetes will prove instructive with respect to potential health claims in these high risk patients with MetS.
- - - - -