Methods for enhancing the ability of an individual, exposed to sunlight, to produce vitamin D via the skin. Pharmaceutical compositions comprising provitamin D and at least one of lumisterol and tachysterol and analogs and derivatives thereof are also disclosed.
A composition comprising a pharmaceutically acceptable carrier and an effective amount of (a) provitamin D or a derivative or analog thereof; (b) at least one of lumisterol and tachysterol or analogs and/or esters thereof, and (c) a pharmaceutically effective carrier, wherein (a) and (b) are present in amounts effective to provide vitamin D or derivatives or analogs and/or esters thereof to an individual at a particular latitude and/or time of the year.
FIELD OF THE INVENTION
 The invention is in the field of cosmetics and medicinal chemistry. In particular, the present invention relates to topical compositions which provide vitamin D and derivatives thereof throughout the year. The topical compositions of the invention allow a user in the high northern and southern latitudes to produce previtamin D on their skin even when exposed to low energy sunlight in the winter as well as in the morning and evening throughout the year. The compositions comprise provitamin D and at least one of tachysterol and lumisterol, and derivatives and analogs thereof, which photoisomerize to previtamin D, and analogs and derivatives thereof.
SUMMARY OF THE INVENTION
 The present invention is related to the discovery that topical formulations comprising provitamin D and derivatives and analogs thereof together with at least one of lumisterol and tachysterol and derivatives and analogs thereof are effective means of providing vitamin D to individuals throughout the year. The present invention utilizes the low energy UV photoconversion of lumisterol and tachysterol and derivatives and analogs thereof to previtamin D and derivatives and analogs thereof during the winter months and high energy UV photoconversion of provitamin D and derivatives and analogs thereof to previtamin D and derivatives and analogs thereof in the summer months as a method of producing vitamin D and derivatives and analogs thereof in the skin throughout the year.
If this works, it will be a real breakthru for getting vitamin D:
- off season,
- other than middle of the day (too hot),
- by seniors
- perhaps those with dark skins
- Who said vitamin D could not be patented
- Search for lumisterol OR tachysterol in VitaminDWiki 34 items as of Nov 2013
- Complex relationship between UVB and vitamin D – April 2012 which contains the following
Both pre-vitamin D3 and vitamin D can absorb UV radiation and this can lead to isomerization of these molecules to form inert photoproducts, such as lumisterol, tachysterol and 5,6-transvitamin D3 as well as suprasterol I and II [14,15].
- Improved health due to vitamin D fortification in Finland which contains the following
In the event of excess UVB radiation, previtamin D3 will be degraded into inactive sterols lumisterol and tachysterol, or be retransformed to 7-DHC
- tachysterol Definition and how to pronounce the word
An isomer of ergosterol that forms vitamin D2 when irradiated with ultraviolet light.