Parkinsonism & Related Disorders
Elena Kwona, Lisa G. Gallagherb, Susan Searles Nielsenb, Gary M. Franklinb, Christopher T. Littella, W.T. Longstreth Jr.c, d, Phillip D. Swansonc, Harvey Checkowayb, d, checko at u.washington.edu
a United States Army, Madigan Army Medical Center, Department of Preventive Medicine, United States
b University of Washington, Department of Environmental and Occupational Health Sciences, Seattle, WA, United States
c University of Washington, Department of Neurology, Seattle, WA, United States
d University of Washington, Department of Epidemiology, Seattle, WA, United States
Background: Human and animal studies, albeit not fully consistent, suggest that vitamin D may reduce risk of Parkinson's disease (PD). Ultraviolet radiation converts vitamin D precursor to the active form. This study examined the hypothesis that working outdoors is associated with a decreased risk of PD.
Methods: PD cases were enrolled from Group Health Cooperative, a health maintenance organization in the Puget Sound region in western Washington State, and the University of Washington Neurology Clinic in Seattle. Participants included 447 non-Hispanic Caucasian newly diagnosed PD cases diagnosed between 1992 and 2008 and 578 unrelated neurologically normal controls enrolled in Group Health Cooperative, frequency matched by race/ethnicity, age and gender. Subjects' amount of outdoor work was estimated from self-reported occupational histories. Jobs were categorized by degree of time spent working outdoors. A ten-year lag interval was included to account for disease latency. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression, with adjustment for age, gender, and smoking.
Results: Outdoor work was inversely associated with risk of PD (outdoor only compared to indoor only): OR = 0.74, 95% CI 0.44–1.25. However, there was no trend in relation to portion of the workday spent laboring outdoors and PD risk.
Conclusion: Occupational sunlight exposure and other correlates of outdoor work is not likely to have a substantial role in the etiology of PD.
- 20 percent less chance of Parkinson’s disease if work outdoors some – Thesis Feb 2013 very similar to the study on this page
- Outdoor trades much less likely to get Parkinson disease – Sept 2010