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Parkinson's disease 4 X more likely if few bowel movements a decade earlier – Aug 2001

Frequency of bowel movements and the future risk of Parkinson's disease.

Neurology. 2001 Aug 14;57(3):456-62. PMID: 11502913
Abbott RD1, Petrovitch H, White LR, Masaki KH, Tanner CM, Curb JD, Grandinetti A, Blanchette PL, Popper JS, Ross GW.


Might this increased risk be due to

  • Less adsorption of Vitamin D from the gut
  • Gut bacteria problems
  • Accumulation of toxins in the body

Note: “In the original description of Parkinson’s disease by none other than Dr. James Parkinson himself, he described a characteristic feature of the disease: constipation, which may precede the diagnosis by many years”

Constipation is frequent in PD, although its onset in relation to clinical PD has not been well described. Demonstration that constipation can precede clinical PD could provide important clues to understanding disease progression and etiology. The purpose of this report is to examine the association between the frequency of bowel movements and the future risk of PD.

Information on the frequency of bowel movements was collected from 1971 to 1974 in 6790 men aged 51 to 75 years without PD in the Honolulu Heart Program. Follow-up for incident PD occurred over a 24-year period.

Ninety-six men developed PD an average of 12 years into follow-up. Age-adjusted incidence declined consistently from 18.9/10,000 person-years in men with <1 bowel movement/day to 3.8/10,000 person-years in those with >2/day (p = 0.005). After adjustment for age, pack-years of cigarette smoking, coffee consumption, laxative use, jogging, and the intake of fruits, vegetables, and grains, men with <1 bowel movement/day had a 2.7-fold excess risk of PD versus men with 1/day (95% CI: 1.3, 5.5; p = 0.007).
The risk of PD in men with <1 bowel movement/day increased to

  • a 4.1-fold excess when compared with men with 2/day (95% CI: 1.7, 9.6; p = 0.001) and to
  • a 4.5-fold excess versus men with >2/day (95% CI: 1.2, 16.9; p = 0.025).

Findings indicate that infrequent bowel movements are associated with an elevated risk of future PD. Further study is needed to determine whether constipation is part of early PD processes or is a marker of susceptibility or environmental factors that may cause PD.

Even after 18 years the publisher wants $39 for the PDF

Created by admin. Last Modification: Thursday May 9, 2019 19:46:44 GMT-0000 by admin. (Version 3)
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