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Pain not relieved by monthly 100,000 IU of vitamin D (need 50,000 IU weekly) – RCT Feb 2018

Monthly vitamin D supplementation, pain, and pattern of analgesic prescription: secondary analysis from the randomized, double-blind, placebo-controlled ViDA study.

Pain. 2018 Feb 24. doi: 10.1097/j.pain.0000000000001189. [Epub ahead of print]


Pages listed in BOTH the categories Intervention and Pain

Pages listed in BOTH the categories Meta-analysis and Pain

Pain - chronic category has the following

Wu Z1, Camargo CA Jr2, Malihi Z1, Bartley J3, Waayer D1, Lawes CMM1, Toop L4, Khaw KT5, Scragg R1.
1 School of Population Health, University of Auckland, Auckland, New Zealand.
2 Dept of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
3 Dept of Surgery, University of Auckland, Auckland, New Zealand.
4 Dept of Public Health & General Practice, The University of Otago, Christchurch, New Zealand.
5 Dept of Public Health, University of Cambridge, Cambridge, England.

Observational studies suggest that vitamin D deficiency is associated with higher risk of pain. However, evidence on the effect of vitamin D supplementation on pain is limited and contradictory. The aim of this study was to compare the effect of monthly high-dose vitamin D supplementation on a pain impact questionnaire (PIQ-6) score and prescription of analgesics in the general population.
We performed a randomized, double-blind, placebo-controlled trial of 5108 community-dwelling participants, aged 50-84 years, who were randomly assigned to receive monthly 100,000-IU capsules of vitamin D3 (n=2558) or placebo (n=2550) for a median of 3.3 years. The PIQ-6 was administered at baseline, year one, and final follow-up. Analgesic prescription data were collected from Ministry of Health. There was no difference in mean PIQ-6 score at the end of follow-up (adjusted mean difference: 0.06; P=0.82) between the vitamin D (n=2041) and placebo (n=2014) participants. The proportion of participants dispensed one or more opioids was similar in the vitamin D group (n=559, 21.9%) compared with placebo (n=593, 23.3%); the relative risk (RR) adjusted for age, sex and ethnicity was 0.94 (P=0.24). Similar results were observed for dispensing of NSAIDs (RR=0.94; P=0.24) and other non-opioids (RR=0.98; P=0.34). Focusing on vitamin D deficient participants (<50 nmol/L, 24.9 %,), there was a lower risk of dispensing NSAIDs in the vitamin D group compared with placebo (RR=0.87; P=0.009); all other subgroup analyses were not significant. Long-term monthly high-dose vitamin D supplementation did not improve mean PIQ-6 score or reduce analgesic dispensing in the general population.

PMID: 29494417 DOI: 10.1097/j.pain.0000000000001189

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