Monthly vitamin D supplementation, pain, and pattern of analgesic prescription: secondary analysis from the randomized, double-blind, placebo-controlled ViDA study.
Pain. 2018 Feb 24. doi: 10.1097/j.pain.0000000000001189. [Epub ahead of print]
Pages listed in BOTH the categories Intervention and Pain
- Pain not relieved by monthly 100,000 IU of vitamin D (need 50,000 IU weekly) – RCT Feb 2018
- Fatigue reduced by a single dose of vitamin D (100,000 IU) – RCT Dec 2016
- Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013
- Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017
- High dose vitamin reduced pain of fibromyalgia, osteoarthritis, and rheumatoid arthritis - July 2015
- Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015
- Growing pains reduced 57 percent by vitamin D therapy – May 2015
- Pain of Diabetic Neuropathy reduced with weekly 50,000 IU vitamin D– CT Feb 2015
- Musculoskeletal pain reduced with 4,000 IU of vitamin D – RCT April 2015
- Pain reduced when enough vitamin D was given – review March 2015
- Less use of musculoskeletal pain drugs if get vitamin D – Feb 2015
- Angina dramatically reduced by injections of vitamin D twice a month (300,000 IU) – Jan 2015
- Growing pains reduced 60 percent by vitamin D supplementation – March 2014
- Fibromyalgia pain with trazodone reduced by 50 percent with weekly 50,000 IU of vitamin D – RCT Nov 2014
- 400,000 IU of vitamin D reduced adult pain and improved quality of life – March 2014
- Fibromyalgia pain reduced with vitamin D intervention that achieved 30-48 ng – RCT Feb 2014
- Higher quality of life associated with higher levels of vitamin D
- Vitamin D loading dose of 1,800,000 IU reduced shinbone tenderness – Feb 2013
- 150,000 IU vitamin D reduced pain in immigrants – RCT Dec 2012
- Breast Cancer medicine pain reduced with 4300 IU vitamin D – RCT June 2012
- 7 improvements in lives of veterans with chronic pain with 50,000 IU vitamin D weekly – June 2012
- Menstrual Pain reduced by vitamin D – RCT 2012, 2014, 2016
- Raynaud's pain decreased with 600,000 IU monthly vitamin D – RCT May 2012
Pages listed in BOTH the categories Meta-analysis and Pain
- Chronic widespread pain reduced a bit by vitamin D ignored dose sizes - meta-analysis Aug 2017
- Chronic Pain reported 38 percent less often if supplemented with Vitamin D – meta-analysis Sept 2016
- Chronic Widespread Pain associated with Vitamin D under 10 ng – meta-analysis Oct 2015
- Does vitamin D treat pain – still not absolutely, positively sure – meta-analysis April 2015
Pain - chronic category has the following
Wu Z1, Camargo CA Jr2, Malihi Z1, Bartley J3, Waayer D1, Lawes CMM1, Toop L4, Khaw KT5, Scragg R1.
1 School of Population Health, University of Auckland, Auckland, New Zealand.
2 Dept of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
3 Dept of Surgery, University of Auckland, Auckland, New Zealand.
4 Dept of Public Health & General Practice, The University of Otago, Christchurch, New Zealand.
5 Dept of Public Health, University of Cambridge, Cambridge, England.
Observational studies suggest that vitamin D deficiency is associated with higher risk of pain. However, evidence on the effect of vitamin D supplementation on pain is limited and contradictory. The aim of this study was to compare the effect of monthly high-dose vitamin D supplementation on a pain impact questionnaire (PIQ-6) score and prescription of analgesics in the general population.
We performed a randomized, double-blind, placebo-controlled trial of 5108 community-dwelling participants, aged 50-84 years, who were randomly assigned to receive monthly 100,000-IU capsules of vitamin D3 (n=2558) or placebo (n=2550) for a median of 3.3 years. The PIQ-6 was administered at baseline, year one, and final follow-up. Analgesic prescription data were collected from Ministry of Health. There was no difference in mean PIQ-6 score at the end of follow-up (adjusted mean difference: 0.06; P=0.82) between the vitamin D (n=2041) and placebo (n=2014) participants. The proportion of participants dispensed one or more opioids was similar in the vitamin D group (n=559, 21.9%) compared with placebo (n=593, 23.3%); the relative risk (RR) adjusted for age, sex and ethnicity was 0.94 (P=0.24). Similar results were observed for dispensing of NSAIDs (RR=0.94; P=0.24) and other non-opioids (RR=0.98; P=0.34). Focusing on vitamin D deficient participants (<50 nmol/L, 24.9 %,), there was a lower risk of dispensing NSAIDs in the vitamin D group compared with placebo (RR=0.87; P=0.009); all other subgroup analyses were not significant. Long-term monthly high-dose vitamin D supplementation did not improve mean PIQ-6 score or reduce analgesic dispensing in the general population.
PMID: 29494417 DOI: 10.1097/j.pain.0000000000001189