Loading...
 
Toggle Health Problems and D

PMS fatigue 2.5X more likely if poor vitamin D Receptor – Sept 2021

Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms

Genes & Nutrition volume 16, Article number: 15 (2021) DOI https://doi.org/10.1186/s12263-021-00696-2
Alicia C. Jarosz, Daniel Noori, Tara Zeitoun, Bibiana Garcia-Bailo & Ahmed El-Sohemy

 Download the PDF from VitaminDWiki
Image

Background
Vitamin D status has been associated with the presence and severity of several premenstrual symptoms (PMSx) in some, but not all studies. Inconsistencies among findings may be explained by unaccounted genetic variation in the vitamin D receptor (VDR).

Objective
To determine whether associations between vitamin D status and individual PMSx are influenced by VDR genotype.

Methods
Seven hundred sixteen women aged 20-29 years old from the Toronto Nutrigenomics and Health study provided plasma samples and completed a questionnaire on the presence and severity of 15 common PMSx. Plasma 25-hydroxyvitamin D (25(OH)D) concentration was measured and participants were categorized into sufficient (≥ 50 nmol/L) and insufficient (< 50 nmol/L) vitamin D status groups. DNA was obtained from blood samples to genotype for a common VDR single nucleotide variant, rs796858. Using logistic regression, odds of experiencing PMSx were compared between vitamin D-sufficient and insufficient women, stratified by genotype.

Results
Among CC homozygotes, insufficient vitamin D status was associated with higher odds of experiencing premenstrual fatigue (OR, 2.53; 95% CI, 1.40, 4.56) and nausea (OR, 2.44; 95% CI, 1.00, 5.95). Among TT homozygotes, insufficient vitamin D status was associated with lower odds of experiencing fatigue (OR, 0.44; 95% CI, 0.20, 0.97) and increased appetite (OR, 0.48; 95% CI, 0.22, 1.04). Insufficient vitamin D status was associated with higher odds of increased appetite in women with the CT genotype (OR, 1.78; 95% CI, 1.03, 3.07). VDR genotype modified the association between vitamin D status and the following PMSx: increased appetite (interaction p = 0.027), fatigue (interaction p = 0.016), and nausea (interaction p = 0.039).

Conclusion
We found evidence that VDR genotype may modify the association between 25(OH)D and some PMSx. Insufficient 25(OH)D was associated with a higher risk of premenstrual fatigue in those with the CC genotype, but lower risk in those with the TT genotype.


Created by admin. Last Modification: Thursday September 23, 2021 13:25:44 GMT-0000 by admin. (Version 4)
PMS fatigue 2.5X more likely if poor vitamin D Receptor – Sept 2021        
4812 visitors, last modified 23 Sep, 2021,
(Cached) Printer Friendly Follow this page for updates

Attached files

ID Name Comment Uploaded Size Downloads
16269 PMS VDR.jpg admin 23 Sep, 2021 51.05 Kb 254
16268 PMD VDR.pdf admin 23 Sep, 2021 567.97 Kb 229