Vitamin D status, oxidative stress, and inflammation in children and adolescents: A systematic review
Critical Reviews in Food Science and Nutrition, https://doi.org/10.1080/10408398.2018.1546671
M. S. Filgueiras, N. P. Rocha, J. F. Novaes & J. Bressan
- Vitamin D decreases oxidative stress – meta-analysis Nov 2018
- Inflammatory diseases: review of vitamin D, with many tables – May 2014
- Vitamin D for Sepsis prevention – June 2018
- Urinary Tract Infection in infants 5.6 X MORE likely if low Vitamin D, 3.3 X LESS likely if supplement – July 2016
- Oxidative stress to DNA prevented by Vitamin D (H2O2, rats) – Jan 2019
Omega-3 also reduces inflammation
- Pollutants increase Respiratory problems, Vitamin D, Omega-3, etc. decrease them – May 2018
- Severe acute pancreatitis treated in 11 ways by Omega-3 in just 7 days – RCT April 2018
Items in both categories Infant-Child and Inflammation are listed here:
- Atopic Dermatitis not helped by small weekly doses of Vitamin D (8K 2y-6y.16K 12y-18y) – RCT March 2024
- High-dose Vitamin D reduced inflammation and insulin resistance (obese children) - Dec 2023
- Sepsis is fought by Vitamin D in 9 ways – Feb 2023
- COVID children with multisystem inflammatory syndrome have less than 10 ng of vitamin D – March 2022
- 8 of 10 pediatric COVID-19 infections were Vitamin D deficient (49 patients) – May 2021
- Hospitalized children with COVID-19 and inflammation had lower vitamin D – March 2021
- Vitamin D might reduce Multisystem Inflammatory Syndrome in children – March 2021
- Septic children have low Vitamin D (54 studies, ignored Vitamin D Receptor) – meta-analysis April 2019
- Urinary Tract Infection in children 4.8 X more likely if low Vitamin D – meta-analysis Feb 2019
- Oxidative stress and inflammation associated with low vitamin D in children – review Dec 2018
- Prostate and Urinary systems much better with higher vitamin D – many studies
- Urinary Tract Infection in infants 5.6 X MORE likely if low Vitamin D, 3.3 X LESS likely if supplement – July 2016
- At birth, lower levels of vitamin D associated with higher levels of inflammation – Jan 2017
- Inflammation (CRP) 3X higher in Winter-Spring neonates with low vitamin D – Nov 2015
- Newborns with sepsis – 9 ng of vitamin D, without sepsis 19 ng – Aug 2015
- Sepsis is both prevented and treated by Vitamin D - many studies
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Vitamin D deficiency is considered a global public health problem with high prevalence in children and adolescents. The majority of the studies in the literature have identified a relationship between vitamin D insufficiency/deficiency and obesity, as well as other traditional cardiometabolic risk factors in children and adolescents. Scarce studies address vitamin D status with oxidative stress and inflammation in the young population. The aim of this systematic review was to evaluate the evidence of the association of vitamin D status with oxidative stress and inflammation in children and adolescents. This is a systematic review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guideline on reporting systematic reviews. Eight studies were selected for this review. All included studies evaluated inflammatory biomarkers and two out of eight evaluated biomarkers of oxidative stress.
The majority of the studies (five out of eight) found association of vitamin D status with biomarkers of oxidative stress and inflammation such as
- C-reactive protein (CRP),
- interleukin-6 (IL-6),
- cathepsin S,
- vascular cell adhesion molecule-1 (VCAM-1),
- malondialdehyde (MDA), myeloperoxidase,
- 3-nitrotyrosine, and
- superoxide dismutase (SOD).
Vitamin D status is associated with oxidative stress and inflammation in the majority of the studies with children and adolescents. Thus, the assessment of vitamin D status is important because it is associated with nontraditional cardiometabolic markers in the pediatric population (review registration: PROSPERO CRD42018109307).