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Off topic - Prostate problem (BPH) reduced by herbs

My 102 year-old father-in-law moved in with us June 2015.
I found that he has to urinate 3 times per night
reviewed people's comments on web forums to see what works.
The following are the scientific studies of of what people have found to work
I have decided to try him on the best three concurrently, and perhaps later narrow down to what is needed.

How the herbs help - Nov 2014

The Pharmacological Effects of Natural Products and Herbs in Benign Prostatic Hyperplasia
Austin J Nutri Food Sci. 2014;2(10): 1054. full free text on-line
Summary: The pharmacological effects of plant extracts in the treatment of BPH.

NameMain mechanisms of action
Saw Palmetto extraction 5α-reductase inhibition; blockage androgen receptors; anti-proliferation; anti-inflammatory activity; prostate smooth muscle relaxation;
Lycopene (tomatoe)5α-reductase inhibition;; anti-proliferation; anti-inflammatory; anti-oxidant activity
Urtica dioica extract (Stinging nettel root WEAK 5α-reductase inhibition; Decreased action of sex hormones;
Pygeum africanum extract 5α-reductase inhibition;; anti-inflammatory activity

Summary figure
   One company states that the ripest berries provide the most benefit

Saw Palmetto (been used for 2000+ years)

Note: One company states that the ripest berries provide the most benefit

JAMA - 1998: similar to finastreride, with fewer adverse events

Saw Palmetto Extracts for Treatment of Benign Prostatic Hyperplasia: A Systematic Review
"However, the evidence suggests that S repens improves urologic symptoms and flow measures. Compared with finasteride, S repens produces similar improvement in urinary tract symptoms and urinary flow and was associated with fewer adverse treatment events. "

Zdravniški Vestnik - 2014: efficacy 70%

Efficacy and safety of drug with plant extract of saw palmetto in patients with lower urinary tract symptoms because of benign prostatic enlargement
12 months 320 mg (Prostasan), IPSS (International Prostate Symptom Score) score reduced from 14 to 11
"patients and doctors rated the efficacy of drug as good (69.7% and 72.4%) "

Pharmacy & Pharmacology International Journal - Dec 2014: appears to be effective

Saw Palmetto, Serenoa repens, in the Treatment of Benign Prostatic Hyperplasia, Mechanisms of Action and Reasons for its Use
"Metaanalyses and systematic reviews of the trials have concluded that S. repens appears to be effective in the treatment of benign prostatic hyperplasia. "
Link includes full free text

New England Journal of Medicine - Feb 2006: small amount did not help

Saw Palmetto for Benign Prostatic Hyperplasia
In this double-blind trial, we randomly assigned 225 men over the age of 49 years who had moderate-to-severe symptoms of benign prostatic hyperplasia to one year of treatment with saw palmetto extract (160 mg twice a day) or placebo.

Examine.com unsure

Saw palmetto has undergone numerous trials and meta-analyses for BPH, with mixed results.

Pygeum (been used by whites for 300+ years)

Europe 1998 multicenter trial

Efficacy and Acceptability of Tadenan®(Pygeum africanum Extract) in the Treatment of Benign Prostatic Hyperplasia (BPH): A Multicentre Trial in Central Europe
2 months of 50 mg twice a day
Initially nocturia was 2.6 times per night. ==>1.8 per night (32% reduction)
Initially International Prostate Symptom Score was 16. ==> 9.6 (40% reduction)
Researchers were surprised to find that many of the benefits lasted for one month after supplementation was stopped.
Publisher wants $52 for the study

Examine.com -~20% reduction

Urinary complications with Benign prostatic hyperplasia appear to be reduced with Pygeum supplementation in the range of 19-23% (including nocturia, residual urine volume,. . .
The bark of Pygeum tends to contain . . β-sitosterol (349-583mg/kg)
Also has a discussion on 2002 Cochrane meta-analysis of Pygeum

Beta Sitosterol (an active ingredient of Pygeum)

Life Extension Foundation - 2005

Report: Beta-Sitosterol
full free text online

Summary of Random Controlled Trials

Cochrane - July 1999 It works

Beta-sitosterols for benign prostatic hyperplasia
"The review found that beta-sitosterol treatments were well tolerated and improved urinary symptoms and flow measures in men with mild to moderate BPH."   full free text for patients, otherwise the publisher charges for the study

Perhaps Vitamin K2 (already taking it)

Hypothesis: Vitamin K will reduce prostate blood vessel problems – Jan 2015

Attached files

ID Name Comment Uploaded Size Downloads
5644 SP2.jpg admin 04 Jul, 2015 22:57 52.51 Kb 1610
5643 LEF RCT.jpg admin 04 Jul, 2015 19:54 28.61 Kb 1355
5642 LEF IPSS.jpg admin 04 Jul, 2015 19:51 16.08 Kb 1487
5641 Herb F1.jpg admin 04 Jul, 2015 18:27 26.49 Kb 2427
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