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Off Topic: LLLT improved Age-related Macular Degeneration in 97 percent of subjects - RCT 2008

Photomed Laser Surg. 2008 Jun;26(3):241-5. doi: 10.1089/pho.2007.2132.
Ivandic BT1, Ivandic T.

OBJECTIVE: The objective of this study of a case series was to examine the effects of low-level laser therapy (LLLT) in patients with age-related macular degeneration (AMD).

BACKGROUND DATA: AMD affects a large proportion of the elderly population; current therapeutic options for AMD are limited, however.

PATIENTS AND METHODS:
In total, 203 patients (90 men and 113 women; mean age 63.4 +/- 5.3 y) with beginning ("dry") or advanced ("wet") forms of AMD (n = 348 eyes) were included in the study. One hundred ninety-three patients (mean age 64.6 +/- 4.3 y; n = 328 eyes) with cataracts (n = 182 eyes) or without cataracts (n = 146 eyes) were treated using LLLT four times (twice per week). A semiconductor laser diode (780 nm, 7.5 mW, 292 Hz, continuous emission) was used for transconjunctival irradiation of the macula for 40 sec (0.3 J/cm2) resulting in a total dose of 1.2 J/cm2. Ten patients (n = 20 eyes) with AMD received mock treatment and served as controls. Visual acuity was measured at each visit. Data were analyzed retrospectively using a t-test.

RESULTS:
LLLT significantly improved visual acuity (p < 0.00001 versus baseline) in 162/182 (95%) of eyes with cataracts and 142/146 (97%) of eyes without cataracts. The prevalence of metamorphopsia, scotoma, and dyschromatopsia was reduced. In patients with wet AMD, edema and bleeding improved. The improved vision was maintained for 3-36 mo after treatment. Visual acuity in the control group remained unchanged. No adverse effects were observed in those undergoing therapy.

CONCLUSION:
In patients with AMD, LLLT significantly improved visual acuity without adverse side effects and may thus help to prevent loss of vision.

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Clipped from the discussion section
LLLT may increase cellular metabolism in choroidea, RPE, and in photoreceptors, where the energy is absorbed by pigments. Regular metabolic processes may be enhanced and repair processes may be triggered or accelerated. Recently, an increase in the expression of heat shock proteins was found in the retinal and choroidal layers after sub-thermal transpupillary application of laser energy.Heat shock proteins (or chaperones) are known to stimulate cellular metabolism and may help prevent premature cell death.


Some Heat Shock Protein studies in VitaminDWiki

Heat Shock Proteins - Wikipedia 2019

  • "Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light,and during wound healing or tissue remodeling"
  • "HSPs are found in virtually all living organisms, from bacteria to humans."

AMD vision improved by red LLLT, and vision was even better 5 year later - 2018


It seems that a good description of "Heat Shock Proteins" would be:
Proteins produced in all animals to repair damage from stresses such as heat and bright light

Created by admin. Last Modification: Tuesday November 5, 2019 00:57:57 GMT-0000 by admin. (Version 15)

Attached files

ID Name Comment Uploaded Size Downloads
11707 LLLT AMD 5 year.pdf PDF 2018 admin 02 Apr, 2019 18:48 723.32 Kb 48
11706 Low-level_laser_therapy_for_the_treatment_of_andro.pdf admin 02 Apr, 2019 18:09 5.22 Mb 42
11705 LLLT AMD.jpg admin 02 Apr, 2019 15:53 60.93 Kb 100
11704 LLLT AMD.pdf admin 02 Apr, 2019 15:53 166.56 Kb 45
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