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Obesity also increases the risk of mental health problems (probably Vitamin D) - June 2023


Obesity as pleiotropic risk state for metabolic and mental health throughout life

Translational Psychiatry volume 13, Article number: 175 (2023)Michael Leutner, Elma Dervic, Luise Bellach, Peter Klimek, Stefan Thurner & Alexander Kautzky

Obesity, a highly prevalent disorder and central diagnosis of the metabolic syndrome, is linked to mental health by clinical observations and biological pathways. Patients with a diagnosis of obesity may show long-lasting increases in risk for receiving psychiatric co-diagnoses. Austrian national registry data of inpatient services from 1997 to 2014 were analyzed to detect associations between a hospital diagnosis of obesity (ICD-10: E66) and disorders grouped by level-3 ICD-10 codes. Data were stratified by age decades and associations between each pair of diagnoses were computed with the Cochran-Mantel-Haenszel method, providing odds ratios (OR) and p values corrected for multiple testing. Further, directions of the associations were assessed by calculating time-order-ratios. Receiving a diagnosis of obesity significantly increased the odds for a large spectrum of psychiatric disorders across all age groups, including depression, psychosis-spectrum, anxiety, eating and personality disorders (all pcorr < 0.01, all OR > 1.5). For all co-diagnoses except for psychosis-spectrum, obesity was significantly more often the diagnosis received first. Further, significant sex differences were found for most disorders, with women showing increased risk for all disorders except schizophrenia and nicotine addiction. In addition to the well-recognized role in promoting disorders related to the metabolic syndrome and severe cardiometabolic sequalae, obesity commonly precedes severe mental health disorders. Risk is most pronounced in young age groups and particularly increased in female patients. Consequently, thorough screening for mental health problems in patients with obesity is urgently called for to allow prevention and facilitate adequate treatment.

Obesity concurrent health problems
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Note: Virtually all of the above are associated with low vitamin D
Suspect that many would decrease if Obese persons were to take enough Vitamin D

 Download the PDF from VitaminDWiki


Trial site news review of the study

Obesity Significantly Increases Risk of Developing Mental Health Disorders Across All Age Groups

  • "Researchers analyzed a population-wide national registry of inpatient hospitalizations in Austria from 1997 to 2014 "
  • "Receiving a diagnosis of obesity significantly increased the odds for a large spectrum of psychiatric disorders across all age groups, including depression, psychosis-spectrum, anxiety, eating and personality disorders. For all co-diagnoses except for psychosis-spectrum, obesity was significantly more often the diagnosis received first. Further, significant sex differences were found for most disorders, with women showing increased risk for all disorders except schizophrenia and nicotine addiction."

VitaminDWiki – Overview Obesity and Vitamin D contains

Obese need more Vitamin D
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  • Normal weight     Obese     (50 ng = 125 nanomole)

Click here for 2014 study

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  • Normal weight     Obese     (50 ng = 125 nanomole)

VitaminDWiki – Obesity is associated with low Vitamin D (and treated by D as well) – Aug 2019 has:

Fast weight loss by Obese Adults: Summary of the data as of Sept 2019
1) 50,000 IU Vitamin D weekly for at least 6 months
   If gut problems, should use a gut-friendly form of vitamin D
2) Add calorie restriction diet and light exercise after ~2 months*
   * Vitamin D levels must be above 30ng/ml to help with weight loss
   * Start losing weight 2 months sooner if take a 50,000 IU daily for a week
3) More weight loss if also add Magnesium or cofactors
   30% Improved Vitamin D response with Magnesium - a Vitamin D Cofactor
   Note: Magnesium reduces weight loss by itself as well
   20% improved vitamin D response if also add Omega-3 a Vitamin D Cofactor
  Note: Omega-3 reduces weight loss by itself as well
4) More weight loss if also improve activation of Vitamin D Receptor
   Vitamin D Receptor activator: 0-30% improved Vitamin D response
   Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019
Update Dec 2019 - Dr. Greger plant-based eating (not diet) for both weight loss and health.
  His book does not mention Vitamin D nor Adenovirus


Low Vitamin D (due to obesity, etc) causes several mental health problems:

Depression
Anxiety
Schizophrenia
Addiction to smoking

Attached files

ID Name Comment Uploaded Size Downloads
19641 Obesity co-diagnosis.jpg admin 04 Jun, 2023 116.19 Kb 81
19640 Obesity as pleiotropic risk state for metabolic and mental health_CompressPdf.pdf admin 04 Jun, 2023 960.44 Kb 64