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Obese children probably need more than 25,000 IU of vitamin D weekly – July 2014

Efficacy and Tolerability of a High Loading Dose (25,000 IU Weekly) Vitamin D3 Supplementation in Obese Children with Vitamin D Insufficiency/Deficiency

Hormone Research in Paediatrics Vol. 82, No. 2, 2014
Radhakishun N.N.E. · van Vliet M. · Poland D.C.W. · Weijer O. · Beijnen J.H. · Brandjes D.P.M. · Diamant M. · von Rosenstiel I.A.

Background: The recommended dose of vitamin D supplementation of 400 IU/day might be inadequate to treat obese children with vitamin D insufficiency. Therefore, we tested the efficacy and tolerability of a high loading dose vitamin D3 supplementation of 25,000 IU weekly in multiethnic obese children, 8-18 years of age, with vitamin D insufficiency/deficiency. Methods: Fasting blood samples were drawn for the assessment of vitamin D. Vitamin D-insufficient/-deficient children (<50 nmol/l) were supplemented, using a high loading dose of 25,000 IU weekly, and measured again 9 weeks later. Vitamin D supplementation was considered effective and tolerable when an increase to vitamin D sufficiency (25(OH)D >50 nmol/l) was reached in >75% without side effects nor reaching toxic levels.

Results: In total, 109 children (mean ± SD age 11.1 ± 3.0, 34.2% boys, 90.8% obese) received vitamin D supplementation. In 84.4% of the children, the vitamin D status improved from insufficiency/deficiency (<50 nmol/l) to sufficiency (≥50 nmol/l). The majority of children that did not reach vitamin D sufficiency reported non-compliance. No side effects were reported, and the highest level reached was far below the threshold for toxicity.

Conclusion: A high loading dose vitamin D3 supplementation is effective and well-tolerated in our cohort of multiethnic obese children with vitamin D insufficiency/deficiency. © 2014 S. Karger AG, Basel


  1. Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M: Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 2008;122:398-417.
  2. Rockell JE, Green TJ, Skeaff CM, Whiting SJ, Taylor RW, Williams SM, Parnell WR, Scragg R, Wilson N, Schaaf D, Fitzgerald ED, Wohlers MW: Season and ethnicity are determinants of serum 25-hydroxyvitamin D concentrations in New Zealand children aged 5-14 years. J Nutr 2005;135:2602-2608.
  3. Alemzadeh R, Kichler J, Babar G, Calhoun M: Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season. Metabolism 2008;57:183-191.
  4. The Health Council of the Netherlands (HCN): Evaluation of the dietary reference values for vitamin D. The Hague, HCN, 2012.
  5. Rajakumar K, Fernstrom JD, Holick MF, Janosky JE, Greenspan SL: Vitamin D status and response to vitamin D3 in obese vs. non-obese African-American children. Obesity 2008;16:90-95.
  6. Aquirre Castaneda R, Nader N, Weaver A, Singh R, Kumar S: Response to vitamin D3 supplementation in obese and non-obese Caucasian adolescents. Horm Res Paediatr 2012;78:226-231.
  7. Van Groningen L, Opdenoordt S, van Sorge A, Telting D, Giesen A, de Boer H: Cholecalciferol loading dose guideline for vitamin D-deficient adults. Eur J Endocrinol 2010;162:805-811.
  8. Vieth R: Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999;69:842-856.
  9. Fredriks A, Van Buuren S, Wit J, Verloove-Vanhorick S: Body index measurements in 1996-1997 compared with 1980. Arch Dis Child 2000;82:107-112.
  10. Belenchia AM, Tosh AK, Hillman LS, Peterson CA: Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial. Am J Clin Nutr 2013;97:774-781.
  11. Jorens PG, Demey HE, Schepens PJ, Coucke V, Verpooten GA, Couttenye MM, Van Hoof V: Unusual D-lactic acid acidosis from propylene glycol metabolism in overdose. J Toxicol Clin Toxicol 2004;42:163-169.
  12. Zosel A, Egelhoff E, Heard K: Severe lactic acidosis after an iatrogenic propylene glycol overdose. Pharmacotherapy 2010;30:219.

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Comments by VitaminDWiki

As with many other studies, this study would have better success if used any combientaion of the following

  1. Had extended the trial for more than 9 weeks
  2. Had used a loading dose
  3. Had used more than 25,000 IU

The lowest optimum level is 40 ng, Their 20 ng goal provides very few health benefits

See also VitaminDWiki

Pages listed in BOTH the categories Infant/Child and Obesity

Overview Obesity and Vitamin D contains the following summary

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