Loading...
 
Toggle Health Problems and D

Non-Hodgkin’s lymphoma associated with poof Vitamin D receptor – Feb 2021

Association between common variants in vitamin D receptor gene and susceptibility to Non-Hodgkin’s lymphoma: a case-control study

Nucleosides, Nucleotides & Nucleic Acids Volume 40, 2021 - Issue 3 https://doi.org/10.1080/15257770.2020.1871488
Mohammad Ali Mashhadi,Narges Arbabi ,Nahid Sepehri Rad,Saman Sargazi &Mahdiyeh Harati-Sadegh

Vitamin D (VDR)-mediated signaling contributes to the cell signaling pathways that affect cancer development. This study is conducted on 104 patients diagnosed with non-Hodgkin’s lymphoma (NHL) and 246 healthy subjects to investigate the link between five genetic variants spanning the VDR gene and the risk of this malignancy in Iranian subjects. The PCR-RFLP method was used for the analysis of BsmI (rs1544410), ApaI (rs7975232), FokI (rs2228570) and TaqI (rs731236) variants. A simple Tetra-ARMS-PCR technique was employed for the genotyping of the Cdx2 (rs11568820) variant. No significant link was found between both groups regarding ApaI (rs7975232) and FokI (rs2228570) variants (P > 0.05). Also, different genetic models of TaqI (rs731236), BsmI (rs1544410) and Cdx2 (rs11568820) polymorphisms were significantly correlated to decreased risk of NHL (Odd ratios <1).
We found three haplotypes were strongly associated with an increased risk of NHL (P < 0.0001). Linkage-disequilibrium (LD) analysis showed a strong linkage between TaqI (rs731236) and BsmI (rs1544410) among NHL case and control subjects. Our findings indicated that functional variants of the VDR gene are linked to a decreased risk of NHL in our population. Further replication studies in different ethnic groups are needed to validate our results.


VitaminDWiki

Cancer - Lymphoma category listing has 23 items along with related searches


Vitamin D Receptor is associated in over 40 autoimmune studies
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

Vitamin D Receptor and Cancers

Items in both categories Vitamin D Receptor and Cancer - Breast:

Items in both categories Vitamin D Receptor and Cancer - Colon:

Items in both categories Vitamin D Receptor and Cancer

Items in both categories Vitamin D Receptor and Cancer - other:

Items in both categories Vitamin D Receptor and Cancer - Skin:

Items in both categories Vitamin D Receptor and Cancer - Prostate:

Items in both categories Vitamin D Receptor and Cancer - Ovarian:


Created by admin. Last Modification: Saturday February 13, 2021 14:51:56 GMT-0000 by admin. (Version 2)
See any problem with this page? Report it (FINALLY WORKS)