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No reduction in Finish fractures with 800 IU Vitamin D3 and Calcium – Dec 2010

Effect of vitamin D(3) and calcium on fracture risk in 65- to 71-year-old women: a populatio n-based 3-year randomized, controlled trial--the OSTPRE-FPS.

J Bone Miner Res. 2010 Jul;25(7):1487-95.
Salovaara K, Tuppurainen M, Kärkkäinen M, Rikkonen T, Sandini L, Sirola J, Honkanen R, Alhava E, Kröger H.
Bone and Cartilage Research Unit, Clinical Research Centre, University of Kuopio, Kuopio, Finland. kari.salovaara at kuh.fi

Antifracture efficacy of high-dose vitamin D (800 IU) and calcium (1000 mg) remains controversial.
To determine whether daily 800 IU of vitamin D and 1000 mg of calcium supplementation prevents fractures, we randomized 3432 women of the population-based Osteoporosis Risk Factor and Prevention (OSTPRE) Study cohort (ages 65 to 71 years) living in the region of northern Savonia, Finland (latitude 62 degrees to 64 degrees N) for 3 years to receive 800 IU of cholecalciferol and 1000 mg of calcium as calcium carbonate or to a control group that did not receive placebo. The main outcome measure was incident fractures. Fracture data were collected in telephone interviews and validated. Data on 3195 women, 1586 in the intervention group and 1609 in the control group, were available for analysis. In adjusted Cox proportional hazards models,

the risk of any fracture decreased in the vitamin D and calcium group by

17% adjusted hazard ratio (aHR) = 0.83; 95% confidence interval (CI) 0.61-1.12, and

the risk of any nonvertebral fracture decreased by 13% (aHR = 0.87; 95% CI 0.63-1.19).

The risk of distal forearm fractures decreased by 30% (aHR = 0.70; 95% CI 0.41-1.20), and

the risk of any upper extremity fractures decreased by 25% (aHR = 0.75; 95% CI 0.49-1.16), whereas
the risk of lower extremity fractures remained essentially equal (aHR = 1.02; 95% CI 0.58-1.80).

None of these effects reached statistical significance.

In conclusion, this study did not produce statistically significant evidence that vitamin D and calcium supplementation prevents fractures in a 65- to 71-year-old general population of postmenopausal women.
2010 American Society for Bone and Mineral Research. PMID: 20200964
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They noticed reductions in many types of fractures, but they were not statistically significant

Their observations disagree with that of many other studies.

Wonder if these elderly women in Finland were taking cod liver oil,. Too much vitamin D may block vitamin D

See also at VitaminDWiki