Thorax 2010;65:A82-A83 doi:10.1136/thx.2010.150961.14
1. R Sathyamurthy, 2. S Manney, 3. A Wood, 4. G Perkins, 5. C Webster, 6. MT Krishna, 7. AH Mansur; Heart of England NHS Trust, Birmingham, UK
Background Vitamin D (VD) has been suggested to play a role in the development of asthma and frequency of asthma exacerbation1. Vitamin D Binding Protein (VDBP) is thought to influence the development of COPD through its immunomodulatory effect2. This study explores the role of vitamin D axis in relation to asthma severity.
Method An observational case control study with a healthy group (H) and subgroups of severity of asthma – steroid ‘naïve’ mild asthma (MA), severe asthma (SA), severe asthma dependent on oral corticosteroids (SACS) and ‘type 1 brittle’ asthma (BA1) was conducted. VD, VDBP, spirometry, Fractional exhaled nitric oxide (FeNO) and exacerbations requiring oral corticosteroids/year (E) were recorded in all the patients. The data were analysed by Kruskal Wallis and Spearmans rank correlation test. The study was conducted between July 2009 and April 2010.
Results Sixty subjects 16M; mean age: 39?years (19–57) were recruited into this study. The parameters measured are shown in Abstract P14 Table 1. We observed no significant difference in serum VD between the healthy group and any of the asthma subgroups (p=0.52), or indeed between all asthmatics grouped together and healthy controls. Similarly, there was no significant difference in serum VDBP between any of the above groups (p=0.52). VD or VDBP serum levels did not correlate with exacerbations (rs=0.08, p=0.28 for VD and rs=?0.04, p=0.76 for VDBP), FEV1, or FeNO.
Conclusion VD and VDBP level in various asthma groups, did not differ significantly from healthy volunteers in this cohort, and did not correlate with lung function, asthma exacerbations, or exhaled nitric oxide. We conclude that vitamin D axis may not play a significant role in asthma severity or exacerbations although a small effect could not be excluded which would require a larger study for confirmation.
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- Asthma should be reduced by vitamin D – literature review Sept 2010 with a nice hypothesis chart
- The Role of Vitamin D in Asthma – Mar 2010
- Vitamin D deficiency is prevalent among asthmatic African-Americans – Aug 2010
- Vitamin D Levels Lung Function and Steroid Response in Adult Asthma – April 2010
- 1200 IU D3 reduced related asthma by 6X – May 2010
- Low Vitamin D associated with asthma - 2010
- Severity of difficult asthma not proportional to vitamin D levels – Nov 2012 same journal, 2 years later