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NB UVB increased vitamin D levels while decreasing psoriasis and CYP27A1 – March 2014

Narrow-band ultraviolet B treatment boosts serum 25-hydroxyvitamin D in patients with psoriasis on oral vitamin D supplementation.

Acta Derm Venereol. 2014 Mar;94(2):146-51. doi: 10.2340/00015555-1685.
Ala-Houhala MJ1, Karppinen T, Vähävihu K, Kautiainen H, Dombrowski Y, Snellman E, Schauber J, Reunala T.

A course of treatment with narrow-band ultraviolet B (NB-UVB) improves psoriasis and increases serum 25-hydroxyvitamin D (25(OH)D). In this study 12 patients with psoriasis who were supplemented with oral cholecalciferol, 20 µg daily, were given a course of NB-UVB and their response measured. At baseline, serum 25(OH)D was 74.14 ± 22.9 nmol/l. At the 9th exposure to NB-UVB 25(OH)D had increased by 13.2 nmol/l (95% confidence interval (95% CI) 7.2-18.4) and at the 18th exposure by 49.4 nmol/l (95% CI 35.9-64.6) above baseline. Psoriasis Area Severity Index score improved from 8.7 ± 3.5 to 4.5 ± 2.0 (p < 0.001). At baseline, psoriasis lesions showed low vitamin D metabolizing enzyme (CYP27A1, CYP27B1) and high human β-defensin-2 mRNA expression levels compared with those of the healthy subjects. In conclusion, NB-UVB treatment significantly increases serum 25(OH)D in patients with psoriasis who are taking oral vitamin D supplementation, and the concentrations remain far from the toxicity level. Healing psoriasis lesions show similar mRNA expression of vitamin D metabolizing enzymes, but higher antimicrobial peptide levels than NB-UVB-treated skin in healthy subjects.

PMID: 23995795

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Pages listed in BOTH the categories Psorasis and UV

Attached files

ID Name Comment Uploaded Size Downloads
4357 4003.pdf admin 12 Sep, 2014 455.25 Kb 867
4356 CYP27A1.jpg admin 12 Sep, 2014 32.08 Kb 1609
4355 NB UVB increase D - studies.jpg admin 12 Sep, 2014 93.89 Kb 1663
4354 NB UVB and vitamin D.jpg admin 12 Sep, 2014 47.80 Kb 1731