Register Log In Login with facebook

Myopia in adults is 8 percent more likely for every 4 ng less Vitamin D – meta-analysis July 2018

Vitamin D and its pathway genes in myopia: systematic review and meta-analysis

British Journal of Ophthalmology doi: 10.1136/bjophthalmol-2018-312159
Shu Min Tang1, Tiffany Lau1, Shi Song Rong1,2, Seyhan Yazar3, Li Jia Chen1, David A Mackey3, Robyn M Lucas4, Chi Pui Pang1, Jason C Yam1


Vision category starts with the following

see also Myopia    Tears often have higher levels of vitamin D than does blood – Sept 2016

Search vitaminDWiki for "macular degeneration" OR AMD 163 items as of Jan 2018

Search VitaminDWiki for CATARACT 275 items as of May 2018

Most visited 10 pages in (category) Vision

Items in both categories Vision and Meta-analysis are listed here:

63 Vision and Vitamin D items

PDF is available free at Sci-Hub   10.1136/bjophthalmol-2018-312159

Objective To conduct a systematic review and meta-analysis of the association of blood vitamin D (25-hydroxyvitamin D, 25(OH)D) concentration and vitamin D pathway genes with myopia.

Methods We searched the MEDLINE and EMBASE databases for studies published up to 29 January 2018. Cross-sectional or cohort studies which evaluated the blood 25(OH)D concentration, blood 25(OH)D3 concentration or vitamin D pathway genes, in relation to risk of myopia or refractive errors were included. Standard mean difference (SMD) of blood 25(OH)D concentrations between the myopia and non-myopia groups was calculated. The associations of blood 25(OH)D concentrations and polymorphisms in vitamin D pathway genes with myopia using summary ORs were evaluated.

Results We summarised seven studies involving 25 008 individuals in the meta-analysis. The myopia group had lower 25(OH)D concentration than the non-myopia group (SMD=−0.27 nmol/L, p=0.001). In the full analysis, the risk of myopia was inversely associated with blood 25(OH)D concentration after adjusting for sunlight exposure or time spent outdoors (adjusted odds ratio (AOR)=0.92 per 10 nmol/L, p<0.0001).
However, the association was not statistically significant for the <18 years subgroup (AOR=0.91 per 10 nmol/L, p=0.13) and was significant only for 25(OH)D3 (likely to be mainly sunlight derived), but not total 25(OH)D (AOR=0.93 per 10 nmol/L, p=0.00007; AOR=0.91 per 10 nmol/L, p=0.15).
We analysed four single nucleotide polymorphisms in the VDR gene from two studies; there was no significant association with myopia.

Conclusions Lower 25(OH)D is associated with increased risk of myopia; the lack of a genetic association suggests that 25(OH)D level may be acting as a proxy for time outdoors.

Created by admin. Last Modification: Monday July 23, 2018 21:30:40 UTC by admin. (Version 1)
See any problem with this page? Report it (FINALLY WORKS)