See also: Study at bottom of this page: 4X more likely to have MS if VDR problem in Mexico
Predisposing role of vitamin D receptor (VDR) polymorphisms in the development of multiple sclerosis: A case-control study.
J Neurol Sci. 2016 Aug 15;367:148-51. doi: 10.1016/j.jns.2016.05.053. Epub 2016 Jun 1.
Abdollahzadeh R1, Fard MS2, Rahmani F3, Moloudi K4, Kalani BS5, Azarnezhad A6.
1Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2Department of Immunology, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran; Student research center, Hamadan University of Medical sciences. Hamadan, Iran.
3Department of Medical Biotechnology, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.
4Department of Radiology and Radiobiology, school of Paramedical Science, Iran University of Medical Sciences, Tehran, Iran.
5Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
6Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Cellular and Molecular research center, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Kurdistan, Iran. Electronic address: Azarnezhad at gmail.com.
Overview MS and vitamin D
Multiple Sclerosis is more likely if poor Vitamin D Receptor (4X Mexico, 3X Iran)– Feb 2017
Receptor Problems are not detected by Vitamin D tests
There are hints that a person has Vitamin D Receptor probems
The articles in both MS and Genetics are:
- CYP2R1 gene problem increases Multiple Sclerosis risk by 1.4X – Dec 2018
- Multiple Sclerosis risk increased due to genes - 22nd study – Aug 2017
- Mendelian proof that low vitamin D (due to 3 genes) increase risk of MS by 20 percent – Nov 2016
- Autoimmune risk gene ZMIZ1 is associated with both MS and Vitamin D – Jan 2017
- Multiple Sclerosis relapse in children is twice as likely having a Vitamin D Gene score of 6 – Oct 2016
- Multiple Sclerosis and obesity share some gene problems (as well as low vitamin D) – June 2016
- Genes make Multiple Sclerosis 2X more likely unless get more vitamin D - Aug 2015
- Multiple Sclerosis is connected to Vitamin D by gene to gene interactions – Aug 2014
- Multiple Sclerosis, gene expression, and vitamin D: Venn diagrams – Aug 2014
- Epigenetics of Multiple Sclerosis – March 2014
- Increased risk of multiple sclerosis risk in African Americans due to genes – June 2013
- 98 pcnt of genes that Vitamin D activates to reduce MS are also activated by Interferon -May 2013
- Transgeneration vitamin D deficiency related to MS was found in mice – Aug 2012
- Epigenetics, vitamin D, and Multiple Sclerosis
- Mutation of Vitamin D gene (CYP27B1) is strongly tied to MS – Dec 2011
- Learning about MS and vitamin D in offspring from mice – Sept 2011
- Vitamin D targets 4 MS genes – May 2011
- Unable to find a gene linking vitamin D and MS – March 2011
- MS and vitamin D may be related by HLA gene – March 2010
- MS due to low level of vitamin D may be due to a specific gene – July 2010
The articles in both MS and Vitamin D Receptor are:
- Immunological effects of vitamin D and their relations to autoimmunity – March 2019
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Multiple Sclerosis risk increased due to genes - 22nd study – Aug 2017
- Multiple sclerosis (relapsing-remitting) increases activation of Vitamin D Receptor by 6.6 X – March 2017
- Multiple Sclerosis is more likely if poor Vitamin D Receptor (4X Mexico, 3X Iran)– Feb 2017
- Multiple Sclerosis about 3 times more likely if Vitamin D Receptor problems – Aug 2016
- Multiple Sclerosis and the Vitamin D Receptor – meta-analysis July 2014
Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) with a complex etiology. Given the Vitamin D receptor (VDR) gene, it is considered an outstanding risk component associated with MS. The aim of the present study has been to explore and emphasize the role of ApaI, BsmI, TaqI and FokI polymorphisms of VDR gene in susceptibility to MS in an Iranian case-control population including 160 patients and 150 healthy controls. All cases were clinically diagnosed with relapsing-remitting (RR) form, and the controls were age, gender, and race matched which were completely in agreement with the case group. PCR-R FLP was conducted for all the SNPs genotyping. The findings of the study showed a significant difference in allele frequency between the cases and controls for ApaI (p<0.0002), BsmI (p<0.0002) and TaqI (p<0.0001), while no significant difference was observed for FokI (P>0.0125).
The results also showed that
- AA genotype polymorphism of ApaI and BsmI (OR=4.6 and OR=2.52, respectively),
- CC genotype of TaqI (OR=2.41) and
- AC genotype of ApaI (OR=1.79)
are associated with the disease status.
Nevertheless, the results revealed the protective role of TT genotype of TaqI (ORs<1), CC genotype of Apal, and GG genotype of BsmI (ORs<1). VDR polymorphisms seem to have a notable connection with MS pathogenesis, however, study of more big population and functional work on the gene structure and its function are recommended.
PMID: 27423580 DOI: 10.1016/j.jns.2016.05.053
Vitamin D receptor gene polymorphisms are associated with multiple sclerosis in Mexican adults - May 2017
Journal of Neuroimmunology, Volume 306, 15 May 2017, Pages 20–24, https://doi.org/10.1016/j.jneuroim.2017.01.009
Víctor Hugo Bermúdez-Moralesa, Geny Fierrosa, Roberto Lopez Lopeza, Gaby Martínez-Navaa, Mario Flores-Aldanab, José Flores-Riverac, Carlos Hernández-Girónd, ,
Multiple sclerosis (MS) is the most prevalent autoimmune inflammatory demyelinating disease of the central nervous system (CNS) in young adults. More than 50 genomic regions have been associated with MS susceptibility.
Due the important immune-modulating properties of Vitamin D, Vitamin D receptor (VDR) gene polymorphisms – which interfere with the actions of Vitamin D- could be related to increased risk of MS.
We studied 120 patients fulfilling the McDonald criteria for MS (81 females and 39 males) and 180 healthy unrelated controls, nested in a case-Control study, and were recruited from the National Institute of Neurology and Neurosurgery, Manuel Velasco Suárez in Mexico City. Genotyping of VDR gene polymorphisms BsmI (rs1544410) and TaqI (rs731236) was performed using TaqMan SNP Genotyping Assay which consists of a predesigned mix of unlabeled polymerase chain reaction (PCR) primers and the TaqMan minor groove binding group (MGB) probe (FAM dye-labeled).
There was a statistically significant, positive association between MS and the T/T genotype of BsmI polymorphism (OR = 4.15; 95%CI 1.83–9.39), showing also a significant positive trend across genotypes (p < 0.01).
This association was also present evaluating the recessive inheritance model of the polymorphism (OR = 3.91; 95%CI 1.77–8.64). When evaluating the association by alleles, the statistically significant positive association seen by genotypes was confirmed in the T allele carriers, showing an OR of 1.83 (95%CI 1.27–2.65) for MS.
We found a positive association of the genetic VDR polymorphisms TaqI (rs731236) and BsmI (rs1544410), with the risk of MS in a sample of Mexican adults.