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Multiple Sclerosis 6X more likely to progress quickly if low vitamin D – Aug 2016

The association of serum 25-hydroxyvitamin D levels with multiple sclerosis severity and progression in a case-control study from China.

J Neuroimmunol. 2016 Aug 15;297:127-31. doi: 10.1016/j.jneuroim.2016.05.022. Epub 2016 May 27.
Zhang Y1, Liu G2, Han X1, Dong H1, Geng J3

VitaminDWiki

Overview MS and vitamin D contains the following summary
Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.

Summary: lack of consensus on how much to prevent, treat, or cure MS.

  • How much Vitamin D to prevent many diseases - such as MS
  • How much Vitamin D is needed to treat MS? There is currently no agreement
       The recommendations range from 40 to 100 ng - which can result of a dose ranging from 3,000 to 20,000 IU/day
  • How Vitamin D is needed to Cure MS?: It appears that 20,000-140,000 IU daily may be needed to CURE the disease
       You must be under the supervision of a doctor who knows what to watch for in your individual situation.
       High doses of Vitamin D cannot be used as a monotherapy.
       You will need to adjust the cofactors: Typically increasing Magnesium and Vitamin K2, and reducing Calcium intake.
       Your doctor will monitor these and might increase your intake of Vitamins B2, C, as well as Omega-3


OBJECTIVE:
Low vitamin D levels had been shown to play a role in the pathogenesis of multiple sclerosis (MS). Currently, there is little information regarding the correlation between levels of vitamin D and MS in Chinese. This study aimed at detection of association between serum 25-hydroxyvitamin D [25(OH) D] concentrations and MS and its relation to the disease severity in Chinese.

METHODS:
The present study was a case-control type, it included 141 patients with definitive MS on the basis of 'McDonald' criteria and 282 age-sex matched controls. All patients were clinically evaluated including disease severity using expanded disability status scale (EDSS) score and progression index (PI). Serum 25(OH) D measurements were performed at baseline.

RESULTS:
The median serum level of 25(OH) D in patients with MS was 15.9 (IQR, 11.4-24.4) ng/mL, which was significantly lower (P<0.0001) than those in healthy controls (20.6 [IQR, 15.3-27.7] ng/mL). There was a negative correlation between levels of 25(OH) D and the EDSS score (r=-0.549, P<0.0001). In multivariate conditional logistic analyses using dichotomous 25(OH) D levels, values less than or equal to 20ng/mL indicted higher risk of MS (OR 1.691, 95 CI: 1.058-2.394; P=0.024). Similarly, in binary logistic multivariate analyses using dichotomous 25(OH) D levels, values less than or equal to 20ng/mL indicted the MS high progression (OR 6.278, 95 CI: 2.662-15.659; P<0.001).

CONCLUSION:
Low serum 25(OH) D levels were associated with increased activity and progression in Chinese patients with MS. Further analytical work is required to establish a causal association between vitamin D status and MS risk and progression.

PMID: 27397085 DOI: 10.1016/j.jneuroim.2016.05.022

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