Persistent Effect of Vitamin D Supplementation on Musculoskeletal Parameters in Adolescents One Year after Trial Completion
Journal of Bone and Mineral Research, 10.1002/jbmr.2802
Nisrine Ghazal MD1,3, Laila Al-Shaar MS, MPH1,5,6, Joyce Maalouf MS1,2, Mona Nabulsi MD, MSc1,4, Asma Arabi MD, MSc1,3, Mahmoud Choucair MD1,3, Hani Tamim PhD1, Ziad Mahfoud PhD7 andGhada El-Hajj Fuleihan MD, MPH1,2,3,5,*
1American University of Beirut Medical Center
2Calcium Metabolism and Osteoporosis Program
3Department of Internal Medicine, Division of Endocrinology
4Department of Pediatrics and Adolescent Medicine
5Scholars in Health Research Program
6Vascular Medicine Program
7Weill Cornell Medical College
* Corresponding author: Ghada El-Hajj Fuleihan, MD, MPH, FRCP.
Professor of Medicine, Director: Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut-Medical Center, PO BOX: 11-0236, Riad El Solh, 1107 2020, Beirut, Lebanon
We had demonstrated a beneficial effect of vitamin D supplementation on musculoskeletal parameters in adolescent girls in a one-year, randomized, double-blinded placebo-controlled trial (RCT). Our objective is to investigate the residual effect of vitamin D supplementation on bone mineral content (BMC), bone mineral density (BMD), at the lumbar spine and hip, lean mass, and height, one-year post-trial completion.
We performed post-hoc analyses in 167 adolescents, 86 girls and 81 boys, 13.9 ± 2 years, who received vitamin D or placebo during trial, and continued into the follow-up trial. Musculoskeletal parameters were measured at baseline, 12 months (intervention), and 24 months (follow-up). T-tests and ANOVA were used to compare results between the placebo group and the merged vitamin D arms (200 or 2000 IU/day), by gender.
Baseline characteristics were comparable between treatment groups at entry into the extension. Girls who had received vitamin D during the trial, had significantly larger hip BMC increments compared to those assigned to placebo, 24 months compared to study entry, but not 24 compared to 12 months, that persisted in adjusted analyses. There were no significant differences in bone mass changes between treatment groups in boys, at either 24 12 or 24 months compared to baseline.
The beneficial effect of vitamin D supplementation on hip bone mass, achieved in girls during the trial, persisted one year post-trial completion. These net cumulative increments, one-year post discontinuation of supplementation, may have important implications on optimizing peak bone mass accretion in adolescent girls. This article is protected by copyright. All rights reserved
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