Preprint speculates that supplemening Vitamin K would decrease COVID-19 problems by decreasing clotting by Cytokine storms
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Introduction: Coronavirus 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2. The majority of patients have at most mild symptoms, however, a significant proportion develops respiratory failure. COVID-19 may also progress beyond the lungs. Coagulopathy and thromboembolism are prevalent in severe COVID-19 and relate to decreased survival. Coagulation is an intricate balance between clot promoting and dissolving processes in which vitamin K plays a well-known role. We hypothesized that vitamin K status is reduced in patients with severe COVID-19.
Methods: Vitamin K status was assessed by measuring desphospho-uncarboxylated matrix Gla protein (dp-ucMGP; inversely related to vitamin K status) and the rate of elastin degradation by measuring desmosine. We included 123 patients who were admitted with COVID-19 and 184 controls.
Results: Dp-ucMGP levels were significantly elevated in COVID-19 patients (1,673Å}1,584 pmol/L) compared to controls (536±291 pmol/L; p<0.0005). Dp-ucMGP levels were significantly higher in COVID-19 patients with unfavorable outcome compared to those with less severe disease. Furthermore, dp-ucMGP and desmosine levels were significantly associated (r=0.65; p<0.0005).
Conclusions: Vitamin K status was reduced in patients with COVID-19 and related to poor prognosis.
Also, low vitamin K status seems to be associated with accelerated elastin degradation.
An intervention trial is now needed to assess whether vitamin K administration improves outcome in patients with COVID-19.
- Longevity expert (David Sinclair) supplements includes Vitamin D, Vitamin K, and Resveratrol – Sept 2019
- Response to Vitamin D increased if take Magnesium and Vitamin K2 – Grassroots March 2020
- Should increase Vitamin K when increasing Vitamin D – RCT Jan 2019
Overview Vitamin K and Vitamin D contains the following summary
Vitamin K2 is similar to D3 in many ways
- Both vitamins were initially confused with its lesser form (D2 ==> D3, K1 ==> K2)
- Both vitamins appear to influence health in large number of ways
- Both vitamins in the body are about 1/10 that of a century ago
Example: Grass-fed beef has a lot more K2, D3, and Magnesium
- Need very little of both vitamins: <1 milligram daily
- When Vitamin D3 is increased, it appears that Vitamin K2 should also be increased
- Vitamin K2 understanding and research is about 20 years behind that of Vitamin D3
One of the reasons: No simple blood test for K2 as of Jan 2020
- Note: Vitamin D blocks Vitamin K – 2015 - perhaps should not take at the same time
Note: it appears that Vitamin K supplementation provides clotting benefits within weeks
Perhaps you should start taking Vitamin K if get COVID-19 symptoms
Authors were concerned that increasing Vitamin K increases Hypertension and Diabetes
Items in both categories Vitamin K and Hypertension are listed here:
Items in both categories Vitamin K and Diabetes are listed here: