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Monthly 60,000 IU of Vitamin D did not reduce mortality (too infrequent)- Feb 2022monthly) will reduce mortality – results due 2024

Poor results published Mortality reduction needs more than monthly 60,000 IU of Vitamin D - RCT Jan 2022

The D-Health Trial: A randomized trial of vitamin D for prevention of mortality and cancer

Contemporary Clinical Trials, Available online 14 April 2016, doi:10.1016/j.cct.2016.04.005
R.E. Nealea, , , B.K. Armstrongb, C. Baxtera, B. Duarte Romeroa, P. Ebelingc, D.R. Englishd, M.G. Kimline, D.S.A. McLeoda, R.L. O′Connellf, J.C. van der Polsg, A.J. Vennh, P.M. Webba, D.C. Whitemana, L. Wocknera

VitaminDWiki Summary

VitaminDWiki expects that little results will be found with 60,000 IU monthly
Elderly need at least 50,000 IU weekly, not monthly, and, one size does NOT fill all
    Random Controlled trials rarely use dose sizes which vary by weight, pre-existing conditions, etc.
See also VitaminDWikii

13 reasons why many seniors need more vitamin D (both dose and level) - July 2023 has the following

  1. Senior skin produces 4X less Vitamin D for the same sun intensity
  2. Seniors have fewer vitamin D receptor genes as they age
    Receptors are needed to get Vitamin D in blood actually into the cells
  3. Many other Vitamin D genes decrease with age
  4. Since many gene activations are not detected by a blood test,
    more Vitamin D is often needed, especially by seniors
  5. Seniors are indoors more than when they were younger
    not as agile, weaker muscles; frail, no longer enjoy hot temperatures
  6. Seniors wear more clothing outdoors than when younger
    Seniors also are told to fear skin cancer & wrinkles
  7. Seniors often take various drugs which end up reducing vitamin D
    Some reductions are not detected by a vitamin D test of the blood
    statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
  8. Seniors often have one or more diseases that consume vitamin D
    osteoporosis, diabetes, Multiple Sclerosis, Cancer, ...
  9. Seniors generally put on weight as they age - and a heavier body requires more vitamin D
  10. Seniors often (40%) have fatty livers – which do not process vitamin D as well
  11. Reduced stomach acid means less Magnesium is available to get vitamin D into the cells
  12. Vitamin D is not as bioavailable in senior intestines
  13. Seniors with poorly functioning kidneys do not process vitamin D as well
       Seniors category has 428 items

The Meta-analysis of Mortality and Vitamin D are listed here:

The Meta-analysis of Mortality and Intervention are listed here:

Promising Vitamin D Clinical Trials - 2017 contains the following

Future Clinical Trials

  • Each page includes links to similar studies/trials
  • The year is shown as 1 year after trial starts, note sometimes publication does not occur until 4 years later.
  • These clinical trials were selected as being likely to show good results by VitaminDWiki in 2017.
  • If an item is of interest. you should consider taking Vitamin D and perhaps other supplements such as Magnesium, Omega-3, and Vitamin K rather than waiting for the results of the clinical trial to be published, or waiting several decades for your doctor to incorporate the results into his practice

See also VitaminDWiki

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Vitamin D, specifically serum 25(OH)D has been associated with mortality, cancer and multiple other health endpoints in observational studies, but there is a paucity of clinical trial evidence sufficient to determine the safety and effectiveness of population-wide supplementation. We have therefore launched the D-Health Trial, a randomized trial of vitamin D supplementation for prevention of mortality and cancer. Here we report the methods and describe the trial cohort.

The D-Health Trial is a randomized placebo-controlled trial, with planned intervention for 5 years and a further 5 years of passive follow-up through linkage with health and death registers. Participants aged 65–84 years were recruited from the general population of Australia. The intervention is monthly oral doses of 60,000 IU of cholecalciferol or matching placebo. The primary outcome is all-cause mortality. Secondary outcomes are total cancer incidence and colorectal cancer incidence.

Results: We recruited 21,315 participants to the trial between February 2014 and May 2015. The participants in the two arms of the trial were well-balanced at baseline. Comparison with Australian population statistics shows that the trial participants were less likely to report being in fair or poor health, to be current smokers or to have diabetes than the Australian population. However, the proportion overweight or with health conditions such as arthritis and angina was similar.

Observational data cannot be considered sufficient to support interventions delivered at a population level. Large-scale randomized trials such as the D-Health Trial are needed to inform public health policy and practice.