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Mild to moderate persistent asthma cost-effectively treated by Vitamin D – Aug 2022


Cost utility of Vitamin D supplementation in adults with mild to moderate asthma

J Asthma. 2022 Aug 3;1-13. doi: 10.1080/02770903.2022.2110113 PDF behind a $59 paywall
Jefferson Antonio Buendía, MD PhD, Carlos E. Rodriguez-Martinez., MD, MSc, PhD & Monica P. Sossa-Briceño, MD., MSc.

Introduction
Uncontrolled asthma significantly impairs health-related quality of life and work productivity. Some add-on therapies, such as vitamin D supplements, safely reduce the rate of asthma exacerbation. The purpose of this study was to assess the cost-utility of vitamin D supplementation in adults with mild to moderate persistent asthma in Colombia.

Methods
A Markov model was created to estimate the cost and quality-adjusted life-years (QALYs) of patients with severe asthma in Colombia. Total costs and QALYs of two therapy strategies, vitamin D supplementation plus ICS versus ICS alone, were calculated over a one-year time horizon. Deterministic and probability sensitivity analyses were conducted, and cost-effectiveness was evaluated at a willingness-to-pay value of $5,180 per QALY gained.

Results
The base-case analysis showed that compared with no supplementation, vitamin D supplementation was associated with higher costs and higher QALYs. The expected annual cost per patient with vitamin D supplementation was US$1338 and without this supplementation it was US$1095. The QALYs per person estimated with vitamin D supplementation was 0,80, and without this supplementation it was 0,63. The estimated incremental cost-effectiveness ratio (ICER) was US$1583 per QALY.

Conclusion
Add-on vitamin D supplement was cost-effective when added to the usual care in patients with mild to moderate persistent asthma. Our study provides evidence that should be used by decision-makers to improve clinical practice guidelines.


VitaminDWiki - Overview Asthma and Vitamin D contains

The worse the bronchial asthma, the lower the vitamin D – Jan 2017
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Intervention pages with ASTHMA in title (14 as of July 2022)

This list is automatically updated

Items found: 15
Title Modified
Resulting childhood Asthma cut in half if 4,400 IU Vitamin D (5 ways to improve it) - RCT April 2023 20 Apr, 2023
Asthma and COPD in a few seniors greatly decreased by monthly 100,000 IU Vitamin D – RCT Feb 2021 28 Jun, 2021
Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017 25 Jul, 2020
Those with Asthma or COPD had half the response to Vitamin D – March 2020 19 Mar, 2020
Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017 12 Mar, 2019
Vitamin D every 14 weeks is not often enough (asthma in this case)– Feb 2019 21 Feb, 2019
All asthma problems reduced after 1 year of Vitamin D – Nov 2017 10 Jul, 2018
Asthma treated by daily 50,000 IU of Vitamin D – April 2018 24 Jun, 2018
Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014 18 Jul, 2017
Reduction of infant asthma may require good vitamin D when lung development starts (4 weeks) – March 2017 02 May, 2017
Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015 15 Jan, 2017
Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016 03 Aug, 2016
Asthma exacerbations with colds reduced by 40 percent with vitamin D supplementation – Nov 2015 25 Nov, 2015
Bronchial Asthma reduced with 60,000 IU monthly vitamin D – RCT Nov 2013 14 Sep, 2014
Asthma reduced by weekly 50,000 IU of vitamin D – RCT Aug 2014 03 Aug, 2014

Meta-analyses with ASTHMA in title (13 as of July 2022)

This list is automatically updated

Items found: 13

Created by admin. Last Modification: Wednesday August 3, 2022 18:55:14 GMT-0000 by admin. (Version 2)