Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly: a repeated measure analysis.
J Korean Med Sci. 2012 Jun;27(6):653-60. Epub 2012 May 26.
Park HY, Lim YH, Kim JH, Bae S, Oh SY, Hong YC.
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
The purpose of current study was to investigate associations of serum 25-hydroxyvitamin D (OHVD) levels with markers for metabolic syndrome in elderly Koreans. We conducted a panel study on 301 individuals over 60 yr old in Seoul, Korea, and repeatedly measured serum OHVD, glucose, insulin, and lipid levels. Mixed effect model and generalized estimating equations were used to investigate relationships between serum OHVD levels with marker levels for metabolic syndrome and each of its categories.
Of all subjects, 76.6% were vitamin D deficient (< 50 nM) and 16.9% were insufficient (< 75 nM).
Inverse association was demonstrated between serum OHVD levels and insulin (P = 0.004), triglyceride (P = 0.023) and blood pressure (systolic blood pressure: P = 0.002; diastolic blood pressure: P < 0.001).
Vitamin D deficiency was found to increase risk of 'hypertriglyceridemia' category of metabolic syndrome (odds ratio: 1.73, 95% confidence interval: 1.13-2.66).
In conclusion, we found from our repeated measure analysis that decreasing serum OHVD levels are associated with increasing insulin resistance, increasing serum triglyceride levels and increasing blood pressure in elderly Koreans, and confirmed on the risk of 'hypertriglyceridemia' in vitamin D deficient subjects.
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- Overview Metabolic Syndrome and vitamin D
- All items in category Metabolic Syndrome
Items in both categories Metabolic Syndrome and Seniors are listed here:
- Risk of Metabolic syndrome for senior women reduced 42 percent by 1,000 IU of vitamin D – RCT June 2019
- Metabolically Healthy – only 1 in 50 seniors in the US – Nov 2018
- Half of Women Over 50 Desperately Need This Potent Nutrient (Vitamin D) – April 2018
- Metabolic syndrome 1.9 X more likely if senior women had less than 30 ng of Vitamin D – Oct 2017
- Low vitamin D with metabolic syndrome increased risk of senior cognitive impairment by 3X – July 2016
- Metabolic Syndrome 40 percent less likely in seniors with vitamin D – Dec 2014
- Metabolic syndrome 2.4 X more likely if senior women had low vitamin D – Nov 2013