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Metabolic syndrome markers in elderly associated with low vitamin D – June 2012

Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly: a repeated measure analysis.

J Korean Med Sci. 2012 Jun;27(6):653-60. Epub 2012 May 26.
Park HY, Lim YH, Kim JH, Bae S, Oh SY, Hong YC.
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.

The purpose of current study was to investigate associations of serum 25-hydroxyvitamin D (OHVD) levels with markers for metabolic syndrome in elderly Koreans. We conducted a panel study on 301 individuals over 60 yr old in Seoul, Korea, and repeatedly measured serum OHVD, glucose, insulin, and lipid levels. Mixed effect model and generalized estimating equations were used to investigate relationships between serum OHVD levels with marker levels for metabolic syndrome and each of its categories.

Of all subjects, 76.6% were vitamin D deficient (< 50 nM) and 16.9% were insufficient (< 75 nM).

Inverse association was demonstrated between serum OHVD levels and insulin (P = 0.004), triglyceride (P = 0.023) and blood pressure (systolic blood pressure: P = 0.002; diastolic blood pressure: P < 0.001).

Vitamin D deficiency was found to increase risk of 'hypertriglyceridemia' category of metabolic syndrome (odds ratio: 1.73, 95% confidence interval: 1.13-2.66).

In conclusion, we found from our repeated measure analysis that decreasing serum OHVD levels are associated with increasing insulin resistance, increasing serum triglyceride levels and increasing blood pressure in elderly Koreans, and confirmed on the risk of 'hypertriglyceridemia' in vitamin D deficient subjects.

PMID: 22690097

Insulin and vitamin D - one of many graphs in the PDF

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See also VitaminDWiki

Items in both categories Metabolic Syndrome and Seniors are listed here:

Attached files

ID Name Comment Uploaded Size Downloads
1613 Insulin vs vitamin D.jpg admin 20 Sep, 2012 13:33 13.69 Kb 834
1612 Metabolic Syndrome June 2012.pdf PDF admin 20 Sep, 2012 13:27 537.87 Kb 566
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