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Melanoma might be suppressed by Vitamin D – Jan 2022


PTEN: a novel target for vitamin D in melanoma

J Steroid Biochem Mol Biol. 2022 Jan 13;106059. doi: 10.1016/j.jsbmb.2022.106059
Artur Shariev 1, Nicole Painter 1, Vivienne E Reeve 2, Nikolas K Haass 3, Mark S Rybchyn 4, Furkan A Ince 1, Rebecca S Mason 5, Katie M Dixon 6

Melanoma is the most dangerous form of skin cancer, with poor prognosis in advanced stages. Vitamin D, also produced by ultraviolet radiation, is known for its anti-proliferative properties in some cancers including melanoma. While vitamin D deficiency has been associated with advanced melanoma stage and higher levels of vitamin D have been associated with better outcomes, the role for vitamin D in melanoma remains unclear. Vitamin D synthesis is initiated upon UVB exposure of skin cells and results in formation of the active metabolite 1,25-dihydroxyvitamin D3 (1,25D). We have previously demonstrated that 1,25D plays a role in protection against ultraviolet radiation-induced DNA damage, immune suppression, and skin carcinogenesis. In this study 1,25D significantly reduced cell viability and increased caspase levels in human melanoma cell lines. This effect was not present in cells that lacked both phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a well-known tumour suppressor, and the vitamin D receptor (VDR). PTEN is frequently lost or mutated in melanoma. Incubation of selected melanoma cell lines with 1,25D resulted in significant increases in PTEN levels and downregulation of the AKT pathway and its downstream effectors. This suggests that 1,25D may act to reduce melanoma cell viability by targeting PTEN.


VitaminDWiki pages with MELANOMA in title (41 as of Jan 2022)

This list is automatically updated

Items found: 41
Title Modified
Melanoma might be suppressed by Vitamin D – Jan 2022 17 Jan, 2022
Overview Suntan, melanoma and vitamin D 28 Nov, 2021
Melanoma not treated by small doses of vitamin D (100,000 IU every 50 days) – RCT June 2021 30 Jun, 2021
Melanoma huge increase - perhaps due to use of sunscreen or lower vitamin D - Aug 2014 26 Apr, 2021
Melanoma associated with vitamin D less than 30 ng (9X) – March 2021 13 Mar, 2021
Recurrence of malignant melanoma may be reduced by 100,000 IU of vitamin D monthly – trial underway 2017 13 Mar, 2021
Melanoma 25 X more likely if low vitamin D – Feb 2018 13 Mar, 2021
Sunlight on skin has decreased 9X while melanoma has increased 30X – Feb 2020 20 Feb, 2020
Melanoma 2.1 X more likely if low vitamin D – meta-analysis Jan 2020 11 Jan, 2020
Melanoma cancer growth slowed by increased Vitamin D Receptor (yet again) – Oct 2019 06 Nov, 2019
Melanoma Is a Disease of Office Workers - Dec 2018 12 Dec, 2018
Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018 20 Nov, 2018
UVB improvements to Vitamin D receptor appear to improve melanoma survival – Oct 2017 09 Oct, 2017
Non-melanoma skin cancer varies with latitude, melanoma does not – April 2017 23 May, 2017
Malignant melanoma may be reduced by skin-activated vitamin D – Nov 2016 27 Jan, 2017
People with metastatic melanoma and initially Vitamin D deficient had 4.7 times worse outcome if not get enough D – Dec 2016 31 Dec, 2016
Vitamin D being considered for Melanoma – active vitamin D is produced by skin – Nov 2016 01 Dec, 2016
Melanoma survival doubled with Vitamin D binding protein polymorphism – Nov 2015 18 Nov, 2015
Will vitamin D loading dose and 50,000 IU monthly will help after melanoma surgery – Oct 2014 24 Oct, 2014
Melanoma REDUCED by those getting the most UV, unless 5 blistering sunburns while in teen years – June 2014 05 Jun, 2014
Death from melanoma (without ulcers) greatly decreased if have lots of vitamin D receptors – May 2014 28 May, 2014
Melanoma and Vitamin D genes - multiple papers 22 Mar, 2014
Subsequent melanomas associated with BsmI gene variation of VDR– May 2011 22 Mar, 2014
Melanoma risk 2X to 4X higher if Vitamin D receptor genes had morphed – March 2014 19 Mar, 2014
Decreased risk of non-melanoma skin cancer by working outdoors in Europe – April 2013 22 Dec, 2013
UV and Melanoma: are they related – 2013 19 Dec, 2013
The Protective Role of Vitamin D Signaling in Non-Melanoma Skin Cancer - Nov 2013 14 Dec, 2013
Melanoma is 44 percent LESS LIKELY if get sun on the job – Nov 2013 01 Dec, 2013
Melanoma not as thick if recently had a sunny vacation – Nov 2013 14 Nov, 2013
UVA most likely causes melanoma to progress– Sept 2011 10 Nov, 2013
Prostate Cancer increased melanoma rate by 2X (vitamin D not mentioned) Nov 2013 09 Nov, 2013
Melanoma and Vitamin D - association is not certain - 2012 14 Jul, 2013
Melanoma reduces by half the amount of vitamin D activated by the skin – March 2013 17 Apr, 2013
Melanoma less likely when far from equator – Oct 2012 07 Dec, 2012
Red-haired mice can get melanoma without UV - Oct 2012 29 Nov, 2012
Hypothesis – worldwide increase in Melanoma due to UVA – Oct 2011 17 Oct, 2012
Sun exposure is associated with increased survival from melanoma – 2005 07 Oct, 2012
No association found between melanoma and low vitamin D levels – Sept 2012 12 Sep, 2012
UVB, Smoking and second cancers after melanoma – Jan 2012 06 Mar, 2012
Perhaps 28-40 ng of vitamin D would be good for Melanoma patients – Feb 2011 06 Mar, 2011
Study Suggests Indoor Tanning Boosts Chances of Melanoma 27 May, 2010

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