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Many diseases prevented if Vitamin D level higher than 50 ng -Sunil June 2024


Physiology of Vitamin D—Focusing on Disease Prevention

Nutrients 2024, 16, 1666. https://doi.org/10.3390/nu16111666
Sunil J. Wimalawansa - Cardiometabolic & Endocrine Institute, North Brunswick, NJ 08902, USA; suniljw at hotmaiI.com

Vitamin D is a crucial micronutrient, critical to human health, and influences many physio­logical processes. Oral and skin-derived vitamin D is hydroxylated to form calcifediol (25(OH)D) in the liver, then to 1,25(OH)2D (calcitriol) in the kidney. Alongside the parathyroid hormone, calcitriol regulates neuro-musculoskeletal activities by tightly controlling blood-ionized calcium concentrations through intestinal calcium absorption, renal tubular reabsorption, and skeletal mineralization.
Be­yond its classical roles, evidence underscores the impact of vitamin D on the prevention and reduction of the severity of diverse conditions such as

  • cardiovascular and metabolic diseases,
  • autoimmune disorders,
  • infection, and
  • cancer.

Peripheral target cells, like immune cells, obtain vitamin D and 25(OH)D through concentration-dependent diffusion from the circulation.

Calcitriol is synthesized intracellularly in these cells from these precursors, which is crucial for their protective physiological actions. Its deficiency exacerbates inflammation, oxidative stress, and increased susceptibility to metabolic disorders and infections; deficiency also causes premature deaths. Thus, maintaining opti­mal serum levels above 40 ng/mL is vital for health and disease prevention. However, achieving it requires several times more than the government's recommended vitamin D doses. Despite extensive published research, recommended daily intake and therapeutic serum 25(OH)D concentrations have lagged and are outdated, preventing people from benefiting.

Evidence suggests that maintaining the 25(OH)D concentrations above 40 ng/mL with a range of 40-80 ng/mL in the population is optimal for disease prevention and reducing morbidities and mortality without adverse effects.

The recommendation for individuals is to maintain serum 25(OH)D concentrations above 50 ng/mL (125 nmol/L) for optimal clinical outcomes. Insights from metabolomics, transcriptomics, and epige­netics offer promise for better clinical outcomes from vitamin D sufficiency. Given its broader positive impact on human health with minimal cost and little adverse effects, proactively integrating vitamin D assessment and supplementation into clinical practice promises significant benefits, including reduced healthcare costs. This review synthesized recent novel findings related to the physiology of vitamin D that have significant implications for disease prevention.
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Table of Contents

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10 summary points by Perplexity AI (June 2024)
  1. Vitamin D Metabolism:
     Vitamin D is hydroxylated in the liver to form calcifediol (25(OH)D) and then in the kidney to form calcitriol (1,25(OH)₂D), which regulates calcium and phosphorus metabolism essential for bone health.
  2. Broader Health Implications:
     Beyond bone health, vitamin D plays a crucial role in preventing cardiovascular and metabolic diseases, autoimmune disorders, infections, and cancer by modulating immune function and reducing inflammation and oxidative stress.
  3. Optimal Serum Levels:
     Maintaining serum 25(OH)D concentrations above 40 ng/mL, with an optimal range of 40-80 ng/mL, is essential for disease prevention and reducing morbidity and mortality. For optimal clinical outcomes, levels above 50 ng/mL are recommended.
  4. Deficiency and Health Risks:
     Vitamin D deficiency, defined as serum 25(OH)D levels below 12 ng/mL, exacerbates inflammation, increases susceptibility to infections and metabolic disorders, and is associated with higher mortality rates.
  5. Public Health Concern:
     Vitamin D deficiency is a widespread issue affecting over half of the global population, particularly those with limited sun exposure. This deficiency is more prevalent than iron deficiency and has significant health implications.
  6. Current Recommendations:
     Government-recommended daily doses of vitamin D (400-1000 IU/day) are insufficient to achieve optimal serum levels. Higher doses are necessary to maintain adequate vitamin D status and prevent various diseases.
  7. Clinical Signs of Deficiency:
     Symptoms of severe vitamin D deficiency include muscle weakness, bone pain, skeletal deformities, increased risk of fractures, and generalized fatigue. These symptoms often overlap with other health conditions.
  8. Non-Classical Actions of Calcitriol:
     Calcitriol synthesized in peripheral target cells, such as immune cells, plays a vital role in immune function, reducing the risk of infections and inflammatory responses. This intracellular synthesis is crucial for its protective actions.
  9. Genetic Influences:
     Genetic factors, such as mutations in the CYP27B1 and CYP2R1 genes, can affect vitamin D metabolism and lead to conditions like rickets. These genetic variations influence the body's ability to synthesize and utilize vitamin D.
  10. Health Economics:
     Addressing vitamin D deficiency through supplementation is cost-effective and can significantly reduce healthcare costs associated with treating diseases linked to vitamin D deficiency. The cost-benefit ratio of prophylactic vitamin D is highly favorable.

See also by the author

In VitaminDWiki

>100 publications in Google Scholar as of June 2024


Half of the people got to 50 ng with 5,000 IU daily

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Note: Virtually all will get >40 ng with 7,000 IU daily (50,000 IU weekly)


VitaminDWiki - Is 50 ng of vitamin D too high, just right, or not enough contains:

Vitamin D Treats
150 ng Multiple Sclerosis *
80 ng Cluster Headache *
Reduced office visits by 4X *
70 ngSleep *
60 ngBreast Cancer death reduced 60%
Preeclampsia RCT
50 ng COVID-19
Fertility
Psoriasis
Infections Review
Infection after surgery
40 ng Breast Cancer 65% lower risk
Depression
ACL recovery
Hypertension
Asthma?
30 ng Rickets

* Evolution of experiments with patients, often also need co-factors


82+ pages have 50 ng in the VitaminDWiki title

This list is automatically updated

Items found: 82
Title Modified
50,000 IU Vitamin D once every 2 weeks – response was 34 ng – RCT April 2017 12 Jun, 2024
Many diseases prevented if Vitamin D level higher than 50 ng -Sunil June 2024 02 Jun, 2024
Is 50 ng of Vitamin D enough to fight COVID - TrialSiteNews - Jan 2024 31 Jan, 2024
50 ng of Vitamin D - 100 hours of noon sunbathing OR 3 dollars of Vit D 05 Aug, 2023
Cognition improved in 5 ways after Vitamin D increased to 32 ng (50,000 weekly) – June 2023 03 Jul, 2023
50 ng level of Vitamin D proven to fight many diseases - Whittle May 2023 17 May, 2023
4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023 01 May, 2023
Fight infections such as COVID with 50 ng of Vitamin D – Sunil Dec 2022 19 Dec, 2022
Mortality reduced by 35 percent if everyone had 50 ng of vitamin D - Grant Oct 2021 09 Dec, 2022
Kidney Inflammation not reduced by 30 ng Vitamin D (many health problems need 50 ng) – Nov 2022 09 Nov, 2022
Complement system (part of innate immunity) needs Vitamin D (50 ng is good) – Sept 2022 01 Oct, 2022
10,000 IU Vitamin D raised basketball player levels (more than 50 ng need to improve performance) – June 2022 01 Aug, 2022
Suggested dosing to get 50 ng of Vitamin D (if healthy) - July 2022 21 Jul, 2022
COVID probably fought by Vitamin D, might need 50 ng - Dr. Patrick Nov 8, 2021 21 Jul, 2022
Is 50 ng of vitamin D too high, just right, or not enough 14 May, 2022
COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021 18 Mar, 2022
Optimal Vitamin D level: 50-90 ng - Dr. Vasquez 18 Mar, 2022
Psoriasis reduced for those getting Vitamin D levels above 50 ng – RCT Feb 2018 11 Mar, 2022
See all vitaminDWiki pages with 50...150 AND ng in title 28 Feb, 2022
Prevent half of T1 Diabetes with vitamin D levels of 50 ng – Dec 2012 04 Jan, 2022
Texas town wants employees above 50 ng of Vitamin D to fight COVID-19 - Dec 24, 2020 26 Nov, 2021
Discussion of COVID and 50 ng of Vitamin D (video and transcript)– Dr. Campbell Nov 17, 2021 19 Nov, 2021
Vitamin D might a risk factor of insulin resistance, diabetes, obesity, etc. (50 ng) – Oct 2021 26 Oct, 2021
Vitamin D and COVID, review of evidence, loading dose if less than 50 ng - Masterjohn Sept 2021 05 Sep, 2021
Less muscle inflammation after exercise if high level of Vitamin D (50 ng) -July 2021 08 Jul, 2021
T-cells need at least 40-50 ng of Vitamin D to fight COVID-19 - June 2021 01 Jun, 2021
Little risk of infection after surgery if have more than 50 ng of vitamin D - 2014 30 May, 2021
50,000 IU of Vitamin D once every 2 weeks achieved 40 ng in 3 months – RCT March 2021 24 Apr, 2021
Jaw joint (TMJ) needs 30-50 ng of Vitamin D and a good VDR – April 2021 14 Apr, 2021
More than 30 ng of vitamin D is sometimes needed (Kidney needs 50 ng) – March 2019 31 Mar, 2021
To protect against COVID-19, how much vitamin D – 20 to 50 ng – March 19, 2021 23 Mar, 2021
5000 IU of vitamin D in daily bread resulted in 50 ng and improved quality of life– May 2014 20 Mar, 2021
How much vitamin D is needed ( perhaps 50 ng for infections) 08 Mar, 2021
Influenza prevented by 40 ng levels or treated with vitamin D hammer (50,000 IU) – June 2015 26 Dec, 2020
Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020 12 Dec, 2020
Diabetes 50X less likely if 30 ng of Vitamin D and intense exercise – April 2018 11 Nov, 2020
Only 1 NCAA basketball player getting 10,000 IU vitamin D daily achieved 50 ng goal – Jan 2020 01 Sep, 2020
Critically Ill or injured patients need 30-50 ng of Vitamin D – Matthews March 2020 18 Mar, 2020
Low Vitamin D symptoms, need 50-80 ng, he takes 5,000 IU – Matthews interview Dec 2019 29 Dec, 2019
NCAA trainers are getting on board the Vitamin D train (40-50 ng)– Nov 2019 16 Nov, 2019
Biology of Vitamin D – 30ng min., 50ng preferred, 1000X lower cost than health problem – Feb 2019 02 Mar, 2019
Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018 23 Jan, 2019
Vitamin D is needed for human fertility – goal is 50 ng – Sept 2018 22 Aug, 2018
Colorectal cancer 60 percent less likely if have more than 50 ng of vitamin D (vs 5 ng) – meta-analysis April 2017 09 Aug, 2018
Korea proposes vitamin D of 20 ng, but notes 20ng increases osteo by 50 percent – Oct 2012 03 Jul, 2018
Half of Tianjin China had less than sufficient vitamin D (IoM of 20-50 ng) - June 2018 04 Jun, 2018
Inflammatory Bowel Disease and Vitamin D review (needs 40-50 ng) – Feb 2018 26 Feb, 2018
Hypertension not controlled by 26 ng of Vitamin D (50,000 IU bi-weekly A-A) – RCT Nov 2017 18 Nov, 2017
Hypothyroidism risk reduced 32 percent in those getting vitamin D levels above 50 ng – Oct 2017 27 Oct, 2017
Chinese women in tropics needed 50,000 IU of Vitamin D monthly to keep above 30 ng – RCT May 2017 14 Jul, 2017
All myopic children had less than 50 ng of vitamin D – March 2016 06 Apr, 2017
A group of 6,000 people have vitamin D levels higher than 50 ng – GrassrootsHealth 29 Jun, 2016
Populations with more than 50 ng of vitamin D 09 Apr, 2016
Staph infection reduced 50 percent when have more than 30 ng of vitamin D – Aug 2011 13 Feb, 2016
Outdoor distance runners had great Vitamin D levels (50 ng) – Dec 2015 24 Dec, 2015
Asthma at age 20 increased if vitamin D during pregnancy was higher than 50 ng – Oct 2015 04 Nov, 2015
Sports benefits from up to 50 ng of Vitamin – meta-analysis - Nov 2012 29 Sep, 2015
Vitamin D more than 40 ng: 1300 IU 50% chance: 5,000 IU 80% chance - Aug 2014 13 Sep, 2015
Many more people now have vitamin D levels above 50 ng, especially seniors – May 2015 20 Jun, 2015
Vitamin D video: calcification, narrow-band UV, 4,000 IU, 50 ng – Dr. DeLuca May 2015 04 Jun, 2015
50 percent more elderly deaths when vitamin D under 18 ng or over 40 ng – Aug 2010 31 May, 2015
Dr. Oz recommends at least 50 ng of vitamin D 20 Mar, 2015
Dr Oz: 50ng of vitamin D - Nov 2009 20 Mar, 2015
Smoking associated with 9 ng less vitamin D age 40-50 – Nov 2014 24 Nov, 2014
Semen worse when vitamin D lower than 20 or higher than 50 ng – Oct 2012 16 Oct, 2014
Fertility in both women and men improves with more vitamin D (but less than 50 ng for men) – Dec 2013 16 Oct, 2014
Pregnant blacks 50 pcnt more likely to be depressed if 3 ng less vitamin D – July 2012 23 Sep, 2014
5000 IU vitamin D3 added daily to bread raised blood levels to 50 ng – 2009 16 May, 2014
Vitamin D update – 40-60 ng ideal, 50K biweekly maintenance – Jan 2014 24 Mar, 2014
Diabetics with 8ng less vitamin D had a 50 percent increase chance of DHCR7 gene variation – Jan 2014 29 Jan, 2014
Dr. Oz again recommends at least 50 ng of vitamin D - Dec 2013 05 Jan, 2014
50,000 IU of vitamin D monthly in winter gets most above 20 ng – RCT Nov 2013 21 Dec, 2013
Dr Oz recommends 50 ng vitamin D blood level 03 Dec, 2013
50,000 IU vitamin D weekly increased levels by 52 ng normally, but only 28 ng if obese – Oct 2013 13 Nov, 2013
At least 5,000 IU Vitamin D to get to optimal 50 ng - LEF Nov 2013 11 Nov, 2013
30 to 50 ng of vitamin D is optimal – Central Europe consensus Sept 2013 23 Sep, 2013
European Osteo group recommends 20-50 ng of vitamin D – Jan 2013 17 Jan, 2013
Probability of knee osteoarthritis up 50 percent if 20 ng less vitamin D – Nov 2011 10 Nov, 2012
Metabolic syndrome 50 percent more likely if under 20 ng of vitamin D - May 2011 23 Jun, 2012
USANA found 5000 IU resulted in 50 ng - Winter 2010 24 Sep, 2011
Vitamin D level of 50 ng may be too high - May 2010 24 Sep, 2011
Athletes need 50 ng/ml of Vitamin D – Cannell and Hollis – 2009 02 Jul, 2011

Attached files

ID Name Comment Uploaded Size Downloads
21259 ToC Sunil.webp admin 02 Jun, 2024 47.05 Kb 50
21258 Sunil May 2024_CompressPdf.pdf admin 02 Jun, 2024 790.53 Kb 18