Nutrition, online 24 October 2018, https://doi.org/10.1016/j.nut.2018.10.018
|< 12 ng||> 12 ng||p (smaller is better)|
|Acute respiratory insufficiency||96%||63%||0.003|
|Acute liver failure||48%||10%||0.002|
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- ICU cost reduced by at least 27,000 dollars if get high dose vitamin D in first week - April 2017
- ICU survival increased with vitamin D single loading dose - JAMA Sept 2014
- Children entering ICU with low vitamin D were 3.5 X more likely to have a poor ICU score– Oct 2018
- Hospital or ICU death about twice as likely if low vitamin D – March 2014
Trauma and surgery category starts with the followingTrauma and Surgery category has
see also Concussions
Overview Fractures and Falls and Vitamin D
Cancer - After diagnosis chemotherapy
Search VitaminDWiki for TBI OR "Traumatic Brain Injury" 798 items as of March 2020
Search VitaminDWiki for cathelecidin OR hCAP18 219 items as of March 2020
Search VitaminDWiki for ICU OR “critical care” OR “intensive care” OR “acute care”
1740 items as of May 2019
Search VitaminDWiki for transplant 794 items as of Jan 2018
PDF is available free at Sci-Hub 10.1016/j.nut.2018.10.018
• 91.6% of ICU patients presented deficiency of serum 25(OH)vitamin D concentrations.
• 25(OH)vitamin D concentrations are strongly associated with prognostic indicators.
• 25(OH)vitamin D concentrations are strongly associated with clinical complications.
Background: Vitamin D deficiency may be associated with comorbidities and poorer prognosis. However, this association in intensive care unit (ICU) patients has not been fully elucidated.
Aim: To investigate whether the serum concentrations of 25-hydroxyvitamin D (25(OH)D) within the first 48 hours after ICU admission are associated with prognostic indicators (APACHE II, SOFA score, Charlson comorbidity index), clinical complications, serum C-reactive protein concentrations, mechanical ventilation duration, and mortality.
Methods: Seventy-one patients were admitted to the ICU, and their concentrations of 25(OH)D in the first 48 hours were analysed. To evaluate the prognostic factors in the ICU, the APACHE II, SOFA score, and Charlson comorbidity index (CCI) questionnaires as well as mechanical ventilation time, CRP and mortality were used.
Results: The mean concentration of 25(OH)D was 17.7 ± 8.27 (range 3.5–37.5) ng/mL, with 91.6% presenting with deficiency at admission. Although no associations were found between serum 25(OH)D concentrations with mechanical ventilation time, CRP, mortality, and APACHE II and SOFA severity scores, we found associations with the CCI when adjusted by age (Model 1: OR=1.64; 95%, 1.14–2.34) and by age, sex and body mass index (BMI) (Model 2: OR=1.59; 95%, 1.10–2.34). In addition, among the comorbidities present, 25(OH)D concentrations were inversely associated with cancer (Crude model OR=3.42; 95%, 1.21–9.64) and liver disease (Crude model OR=9.64; 95%, 2.28–40.60).
Conclusion: We found a strong association between 25(OH)D concentrations and the prognostic indicator CCI and clinical complications (acute respiratory insufficiency, acute liver failure and infections), but no associations with the prognostic indicators APACHE II and SOFA score, CRP, MV duration and mortality. The main comorbidities associated with low 25(OH)D were cancer and liver disease, suggesting that the determination of 25(OH)vitamin D is relevant during the ICU stay.
|816 visitors, last modified 27 Oct, 2018, URL: