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Low vitamin D associated with increased COVID-19 risk (in this case black women 1.7X) – July 2021

Lower serum 25(OH)D levels associated with higher risk of COVID-19 infection in U.S. Black women

PLoS One . 2021 Jul 27;16(7):e0255132. doi: 10.1371/journal.pone.0255132
Yvette C Cozier 1 yvettec at bu.edu, Nelsy Castro-Webb 1, Natasha S Hochberg 2 3, Lynn Rosenberg 1, Michelle A Albert 4, Julie R Palmer 1


for 1,974 US black women who had vitamin D blood tests taken 3-7 years before COVID-19
<20 ng vs >30 ng
Odd Ratio adjusted for age, body mass index, geographic region, neighborhood SES score, years of education, cigarette smoking, season of blood draw, household size, and working conditions during the pandemic

Low Vitamin D AND Obese

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Objective: Limited evidence suggests that higher levels of serum vitamin D (25(OH)D) protect against SARS-CoV-2 virus (COVID-19) infection. Black women commonly experience 25(OH)D insufficiency and are overrepresented among COVID-19 cases. We conducted a prospective analysis of serum 25(OH)D levels in relation to COVID-19 infection among participants in the Black Women's Health Study.

Methods: Since 1995, the Black Women's Health Study has followed 59,000 U.S. Black women through biennial mailed or online questionnaires. Over 13,000 study participants provided a blood sample in 2013-2017. 25(OH)D assays were performed in a certified national laboratory shortly after collection of the samples. In 2020, participants who had completed the online version of the 2019 biennial health questionnaire were invited to complete a supplemental online questionnaire assessing their experiences related to the COVID-19 pandemic, including whether they had been tested for COVID-19 infection and the result of the test. We used logistic regression analysis to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association of 25(OH)D level with COVID-19 positivity, adjusting for age, number of people living in the household, neighborhood socioeconomic status, and other potential confounders.

Results: Among 5,081 eligible participants whose blood sample had been assayed for 25(OH)D, 1,974 reported having had a COVID-19 test in 2020. Relative to women with 25(OH)D levels of 30 ng/mL (75 nmol/l) or more, multivariable-adjusted ORs for COVID-19 infection in women with levels of 20-29 ng/mL (50-72.5 nmol/l) and <20 ng/mL (<50 nmol/l) were, respectively, 1.48 (95% CI 0.95-2.30) and 1.69 (95% CI 1.04-2.72) (p trend 0.02).

Conclusion: The present results suggest that U.S. Black women with lower levels of 25(OH)D are at increased risk of infection with COVID-19. Further work is needed to confirm these findings and determine the optimal level of 25(OH)D for a beneficial effect.

Created by admin. Last Modification: Saturday August 21, 2021 16:42:45 GMT-0000 by admin. (Version 8)

Attached files

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15982 Black obese women.jpg admin 28 Jul, 2021 19.56 Kb 349
15981 Black women COVID-19.jpg admin 28 Jul, 2021 37.79 Kb 396
15980 Black women vitamin D COVID_compressed.pdf admin 28 Jul, 2021 276.89 Kb 406