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Low vitamin D associated with COVID-19 problems in NYC hospitals – Feb 2021

An Evaluation of Serum 25-Hydroxy Vitamin D Levels in Patients with COVID-19 in New York City

J Am Coll Nutr. 2021 Feb 19;1-6. doi: 10.1080/07315724.2020.1869626
Elizabeth Marie Gavioli 1 2, Hirotaka Miyashita 2, Omar Hassaneen 1, Evan Siau 2 3


Vitamin D levels were tested at admission or within 2 months before entering the hospital
March and April of 2020
2.2X more likely to need Oxygen support if <20 ng of Vitamin D

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NOTE: The Y axis does not go from 0 to 100%, but rather 75% to 100%



Aim: Deterioration of patients from COVID-19 is associated with cytokine release syndrome attributed to an elevation in pro-inflammatory cytokines. Vitamin D reduces proinflammatory cytokines, and has the possibility of reducing complications from respiratory tract illnesses.

Method: This was a retrospective, observational, cohort study of patients with COVID-19 disease within a New York City Health System. Adult patients were included if they tested positive for SARS-CoV-2, and had a serum 25-hydroxy vitamin D level (25(OH)D) within the three previous months prior to their detected SARS-CoV-2 test. Patients were compared and evaluated based upon their 25(OH)D levels. The primary endpoints were hospitalization, need for oxygen support, and 90-day mortality.

Results: 437 COVID-19 patients were included [67 (IQR: 56-79) years] within this cohort. Deficient plasma 25(OH)D levels (<20 ng/ml) were associated with an increased likelihood of oxygen support [OR:2.23 (95% CI: 1.46-3.44, p = 0.0002)] from COVID-19. Deficient plasma 25(OH)D levels were not independently associated with 90-day mortality or risk of hospitalization. Hospitalization rates (98%), oxygen support (93%), and mortality rates (49%) were highest in patients who had 25(OH)D levels less than 10 ng/ml when compared to other 25(OH)D levels.

Conclusion: Serum 25-hydroxy vitamin D levels may affect the need for oxygen support therapy in patients with COVID-19.

Created by admin. Last Modification: Saturday February 20, 2021 16:35:15 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
15075 NYC F1 mortality.jpg admin 20 Feb, 2021 32.33 Kb 387
15074 NYC F1 Oxygen.jpg admin 20 Feb, 2021 32.66 Kb 326
15073 NYC F1 Hospitalizaion.jpg admin 20 Feb, 2021 32.29 Kb 321
15072 COVID-19 Vitamin D NYC.pdf admin 20 Feb, 2021 980.90 Kb 351