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Low Mortality if more than 20 ng of Vitamin D (UK Biobank) – Oct 2020

Vitamin D Status and Risk of All-Cause and Cause-Specific Mortality in a Large Cohort: Results From the UK Biobank

J Clin Endocrinol Metab . 2020 Oct 1;105(10):dgaa432. doi: 10.1210/clinem/dgaa432.
Xikang Fan 1 , Jiayu Wang 1 , Mingyang Song 2 3 4 , Edward L Giovannucci 2 3 5 , Hongxia Ma 1 6 7 , Guangfu Jin 1 6 7 , Zhibin Hu 1 6 7 , Hongbing Shen 1 7 , Dong Hang 1 7


Context: Although an inverse association between vitamin D status and mortality has been reported in observational studies, the precise association shape and optimal vitamin D status remain undetermined.

Objective: To investigate the association between vitamin D status and risk of all-cause and cause-specific mortality and estimate optimal serum 25-hydroxyvitamin D [25(OH)D] concentrations.

Design: Prospective cohort study.

Setting: UK Biobank.

Participants: 365,530 participants who had serum 25(OH)D measurements and no history of cardiovascular disease (CVD), cancer, or diabetes at baseline (2006-2010).

Main outcome measures: All-cause and cause-specific mortality.

Results: During a median follow-up of 8.9 (interquartile range: 8.3-9.5) years, 10,175 deaths occurred, including 1,841 (18.1%) due to CVD and 5,737 (56.4%) due to cancer. The multivariate analyses revealed nonlinear inverse associations, with a decrease in mortality risk appearing to level off at 60 nmol/L of 25(OH)D for all-cause and CVD deaths and at 45 nmol/L for cancer deaths.
Compared to participants with 25(OH)D concentrations below the cutoffs, those with higher concentrations had a

  • 17% lower risk for all-cause mortality (hazard ratio [HR]: 0.83, 95% confidence interval [CI]: 0.79-0.86), (24 ng)
  • 23% lower risk for CVD mortality (HR: 0.77, 95% CI: 0.68-0.86), (24 ng)
  • 11% lower risk for cancer mortality (HR: 0.89, 95% CI: 0.84-0.95).(18 ng)

Conclusions: Higher 25(OH)D concentrations are nonlinearly associated with lower risk of all-cause, CVD, and cancer mortality. The thresholds of 45 to 60 nmol/L might represent an intervention target to reduce the overall risk of premature death, which needs further confirmation in large clinical trials.
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People die sooner if they have low vitamin D
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There are 292 articles in Mortality category

28 Mortality Meta-analyses

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Mortality and Virus 51 studies

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38 Google Scholar citations of this study as of Aug 2022

Citations that included COVID in their title

  1. Vitamin D3 for reducing mortality from cancer and other outcomes before, during and beyond the COVID-19 pandemic: A plea for harvesting low-hanging fruit - July 2022 https://doi.org/10.1002/cac2.12328 FREE PDF
  2. Vitamin D and COVID-19 —Revisited - July 2022 https://doi.org/10.1111/joim.13536 FREE PDF
  3. Vitamin D and COVID-19: evidence and recommendations for supplementation December 2020 https://doi.org/10.1098/rsos.201912 FREE PDF
  4. Low serum 25-hydroxyvitamin D (25OHD) levels in patients hospitalized with COVID-19 are associated with greater disease severity - . 2020 Nov; https://doi.org/10.1111/cen.14310.FREE PDF
  5. New Roles for Vitamin D Superagonists: From COVID to Cancer - March 2021 https://doi.org/10.3389/fendo.2021.644298 FREE PDF

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Attached files

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18267 Vit D cause mortality Biobank - in Chinese.pdf admin 09 Aug, 2022 21:02 978.37 Kb 81
18266 Other Mortality.jpg admin 09 Aug, 2022 20:55 27.00 Kb 128
18265 All Cause.jpg admin 09 Aug, 2022 20:54 25.79 Kb 135
18264 Vit D cause mortality Biobank_CompressPdf.pdf PDF 2020 admin 09 Aug, 2022 20:31 235.57 Kb 87