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Lots of Vitamin D needed weekly during Breast Cancer Treatment (mean 20,000 IU up to 140,000 IU) – March 2024

  • Personalized Vitamin D dosing ranged from 2,000 IU to 140,000 weekly for Breast Cancer:
    • A range of 70 to 1
  • Treating healthy people typically requires a range of Vitamin D of only 4 to 1
  • The women getting Breast Cancer treatment were clearly not uniformly unhealthy
  • The study failed to note improvement in outcomes vs women not getting Vitamin D
    • Shorter treatment durations, less chemo used, less recurrence

Course of Vitamin D Levels in Newly Diagnosed Non-Metastatic Breast Cancer Patients over One Year with Quarterly Controls and Substitution

Nutrients. 2024 Mar 15;16(6):854. doi: 10.3390/nu16060854.
Cosima Zemlin 1 2, Laura Altmayer 1, Marina Lang 1, Julia Theresa Schleicher 1, Caroline Stuhlert 1, Carolin Wörmann 1, Laura-Sophie Scherer 1, Ida Clara Thul 1, Lisanne Sophie Spenner 1, Jana Alisa Simon 1, Alina Wind 1, Elisabeth Kaiser 3 4, Regine Weber 3 4, Sybelle Goedicke-Fritz 3 4, Gudrun Wagenpfeil 5, Michael Zemlin 3, Erich-Franz Solomayer 1, Jörg Reichrath 6, Carolin Müller 1 2 7


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Apparently they adjusted dosing quarterly (goal of 30 to 100 ng): used 2,000 to 140,000 IU weekly

Background: Vitamin D levels in patients remain inadequately understood, with research yielding inconsistent findings. Breast cancer patients, particularly due to oncological therapies, face an increased risk of osteopenia, which can be exacerbated by a vitamin D deficiency.

Methods: The prospective observational "BEGYN-1" study assessed serum 25(OH D levels at baseline and quarterly thereafter. Clinical, pathological, nutritional, vitamin supplementation, and lifestyle data were recorded.

Results: Before treatment, 68.5% of patients were vitamin D deficient (<30 ng/mL), with 4.6% experiencing severe deficiency (<10 ng/mL). The median baseline 25(OH)D levels were 24 ng/mL (range: 4.8 to 64.7 ng/mL). Throughout the study, the median vitamin D levels increased to 48 ng/mL (range: 22.0 to 76.7 ng/mL). Before diagnosis, 16.7% received vitamin D substitution, and 97.8% received vitamin D substitution throughout the year with a median weekly dose of 20,000 IU. It took at least three quarterly assessments for 95% of patients to reach the normal range. A multiple GEE analysis identified associations between 25(OH)D levels and supplementation, season, age, VLDL, magnesium levels, and endocrine therapy.

Conclusions: Physicians should monitor 25(OH)D levels before, during, and after oncological therapy to prevent vitamin D deficiency and to adjust substitution individually. While variables such as seasons, age, VLDL, magnesium, diet, and oncological interventions affect 25(OH)D levels, supplementation has the greatest impact.
 Download the PDF from VitaminDWiki

VitaminDWiki - 22 studies in both categories Breast Cancer and After Cancer Diagnosis

This list is automatically updated

VitaminDWiki - Vitamin D: not one size, type, form, route for all - Jan 2022

VitaminDWiki - Huge variation in response to vitamin D supplementation – personal vitamin D response index – Dec 2016

VitaminDWiki - Personalized treatment of Vitamin D

VitaminDWiki – Cancer - After diagnosis category contains:

  • Most cancers reduce vitamin D levels
  • Most cancer treatments (chemo, radiation) further lower Vitamin D
  • Higher levels of vitamin D minimize many side-effects of cancer therapy
  • High levels of vitamin D augment many chemotherapies
  • High levels of vitamin D augment cancer immunotherapies
  • High levels of vitamin D can kill some cancer cells 1,720 items 12/2023
  • Some cancers deactivate the vitamin D receptor

Example VitaminDWiki Studies

Breast Cancer

Attached files

ID Name Comment Uploaded Size Downloads
21038 BC 12 months table.png admin 29 Mar, 2024 62.12 Kb 62
21037 20K weekly BC.png admin 29 Mar, 2024 80.18 Kb 26
21036 BC 12 months.png admin 29 Mar, 2024 51.66 Kb 31
21035 BC Baseline.png admin 29 Mar, 2024 58.83 Kb 28
21034 BC 20K weekly average_CompressPdf.pdf admin 29 Mar, 2024 333.50 Kb 10