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Lost more weight on diet if also took 50,000 IU of vitamin D weekly – RCT Sept 2018

Effect of vitamin D supplementation along with weight loss diet on meta-inflammation and fat mass in obese subjects with vitamin D deficiency: a double-blind placebo-controlled randomized clinical trial.

Clin Endocrinol (Oxf). 2018 Sep 24. doi: 10.1111/cen.13861. [Epub ahead of print]
Lotfi-Dizaji L1, Mahboob S2, Aliashrafi S1, Vaghef-Mehrabany E1, Ebrahimi-Mameghani M3, Morovati A1.
1 Student Research Committee, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Nutritional Biochemistry, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Nutrition Research Center, Faculty of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

VitaminDWiki
Vitamin DPlacebo p value
kilogram before99.6099.65-
kilogram after92.6194.860.038 (good)

VitaminDWiki suggests significantly more weight loss if any of the following

  1. Started Vitamin D about 8 weeks before diet
  2. Used more vitamin D
  3. Used a gut-friendly form of Vitamin D
  4. Started with Vitamin D loading dose
  5. Included exercise - even walking
  6. Intervention lasted longer

Overview Obesity and Vitamin D contains the following summary


Items in both of the categories of Intervention AND Obesity

current study is not a news item


PDF is available free at Sci-Hub  10.1111/cen.13861

BACKGROUND & AIMS:
Low serum 25-hydroxy-vitamin D (25OHD) is common in obese people. Obesity is associated with a state of low-grade inflammation (meta-inflammation). There is increasing evidence indicating that vitamin D has anti-adipogenic activity and immunoregulatory effect. This study aimed to assess the effect of vitamin D supplementation on meta-inflammation and fat mass in obese subjects with vitamin D deficiency.

MATERIALS AND METHODS:
In this double-blind placebo-controlled randomized clinical trial, 44 obese subjects with vitamin D deficiency (25OHD < 50 nmol/L) were assigned into vitamin D (a weight reduction diet + bolus weekly dose of 50000 IU vitamin D) or placebo group (weight reduction diet + edible paraffin weekly) for 12 weeks. Weight, fat mass and serum levels of 25OHD, Calcium, Parathyroid hormone (PTH), Monocyte chemoattractant protein 1 (MCP-1), Interleukin-1β (IL-1β), and Toll like receptor 4 (TLR-4) were assessed before and after the intervention.

RESULTS:
Vitamin D supplementation resulted in significant increase of serum 25OHD level (P<0.001), and significant decrease in PTH (P<0.001), MCP-1 (p<0.05), IL-1β (p< 0.05), and TLR-4 (P<0.05); compared to the baseline values in vitamin D group. Weight, BMI and fat mass decreased in both groups (P<0.05). Between the groups, there were significant decrease in weight, fat mass and serum MCP-1 concentrations and significant increase in serum 25OHD and PTH concentrations after intervention with vitamin D supplementation compared to placebo (p<0.05).

CONCLUSIONS:
Improvement in vitamin D status in obese subjects with vitamin D deficiency in combination weight loss diet resulted in weight, fat mass, and MCP-1 decrease. Weight loss and vitamin D supplementation may act synergistically to reduce levels of meta-inflammation.

Created by admin. Last Modification: Tuesday October 2, 2018 21:51:33 UTC by admin. (Version 5)
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