Table of contents
- VitaminDWiki pages with LONGEVITY etc in title (31 as of Nov 2022)
- VitaminDWiki Mortality category contains
- Methylation of Vitamin D genes changes vitamin D getting to cells- Dec 2016
- Vitamin D supplementation is associated 2 year slower epigenetic aging - May 2022
- A Review: Highlighting the Links between Epigenetics, COVID-19 Infection, and Vitamin D - Oct 2022
- VitaminDWiki is trying to arrange a 30,000 person vitamin D trial - which may show improved longevity
- 2 Vitamin D megatrials (>5,000 people) on reducing all-cause mortality are underway - 2021
- See also VitaminDWiki
VitaminDWiki pages with LONGEVITY etc in title (31 as of Nov 2022)
This list is automatically updated
VitaminDWiki Mortality category contains
People die sooner if they have low vitamin D
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This list is automatically updated
- Maternal pregnancy problems if Vitamin D is less than 40 ng – meta-analysis Oct 2022
- COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019
- Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019
- Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
- Prostate Cancer death 40 percent less likely if 40 ng level of vitamin D – Meta-analysis Oct 2018
- Review of meta-analyses of non-skeletal benefits of vitamin D (Mortality, RTI, etc) – July 2017
- Chronic Kidney Disease mortality is 60 percent less likely if good vitamin D – meta-analysis July 2017
- Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
- Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017
- ICU patients 30 percent less likely to die if have enough vitamin D – meta-analysis Nov 2016
- Less likely to die if have enough vitamin D - Meta-analysis June 2014
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Death due to breast cancer reduced 40 percent if high vitamin D – meta-analysis April 2014
- Vitamin D reduces risk of cause specific death, unless it is D2 – meta-analysis BMJ April 2014
- More survive Breast Cancer if more vitamin D – 2X fewer deaths with just 30 ng -meta-analysis March 2014
- Colorectal and Breast Cancer – Vitamin D is associated with fewer deaths – meta-analysis Feb 2014
- Death of women from cancer 24 percent less likely if 20 ng more vitamin D – meta-analysis Sept 2013
- Chance of dying increases by 25 percent in seniors if low vitamin D – Meta-analysis July 2013
- Breast Cancer survival 2X more likely if vitamin D sufficient – meta-analysis May 2013
- Vitamin D with Calcium reduces mortality by 7 percent – meta-analysis May 2012
- Death rate reduced 8 percent for 8 nanogram more vitamin D – meta-analysis Feb 2012
- 40 ng Vitamin D perhaps optimal for reduced mortality – Meta-analysis Jan 2012
- Vitamin D3 but not D2 reduces mortality – meta-analysis July 2011
- Vitamin D and mortality a meta-analysis of RCT - 2008
Methylation of Vitamin D genes changes vitamin D getting to cells- Dec 2016
Relationship between methylation status of vitamin D-related genes, vitamin D levels, and methyl-donor biochemistry
Journal of Nutrition & Intermediary Metabolism Volume 6, December 2016, Pages 8-15 https://doi.org/10.1016/j.jnim.2016.04.010
Emma LouiseBeckett a b KonstaDuesingb CharlotteMartina PatriceJonesa JohnFurstcKatrina KingdSuzanne Niblettd ZoeYatese Martin Veysey df Mark Lucocka
- Plasma 25(OH)D positively correlates with methylation status of the vitamin D receptor gene.
- Vitamin D status relates to the methylation status of the genes of key enzymes involved in vitamin D metabolism.
- DNA methylation may influence vitamin D metabolism, possibly explaining varied responses to intake.
- Methyl-donor related biochemistry (serum folate, B12, plasma homocysteine) does not significantly alter these relationships.
Vitamin D is known for its role in the regulation of gene expression via the vitamin D receptor, a nuclear transcription factor. More recently, a role for vitamin D in regulating DNA methylation has been identified as an additional mechanism of modulation of gene expression. How methylation status influences vitamin D metabolism and response pathways is not yet clear.
Therefore, we aimed to assess the relationship between plasma 25-hydroxycholecalciferol (25(OH)D) and the methylation status of
- vitamin D metabolism enzyme genes (CYP2R1, CYP27B1 and CYP24A1) and the
- vitamin D receptor gene (VDR).
This analysis was conducted in the context of dietary vitamin D, and background methyl donor related biochemistry, with adjustment for several dietary and lifestyle variables. Percentage methylation at CpG sites was assessed in peripheral blood cells using methylation sensitive and dependent enzymes and qPCR. Standard analytical techniques were used to determine plasma 25(OH)D and homocysteine, and serum folate and B12, with the relationship to methylation status assessed using multi-variable regression analysis. CYP2R1 and VDR methylation were found to be independent predictors of plasma 25(OH)D, when adjusted for vitamin D intake and other lifestyle variables. CYP24A1 was related to plasma 25(OH)D directly, but not in the context of vitamin D intake. Methyl-group donor biochemistry was associated with the methylation status of some genes, but did not alter the relationship between methylation and plasma 25(OH)D.
Modulation of methylation status of CYP2R1, CYP24A1 and VDR in response to plasma 25(OH)D may be part of feedback loops involved in maintaining vitamin D homeostasis, and may explain a portion of the variance in plasma 25(OH)D levels in response to intake and sun exposure. Methyl-group donor biochemistry, while a potential independent modulator, did not alter this effect.
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Vitamin D supplementation is associated 2 year slower epigenetic aging - May 2022
GeroScience volume 44, pages 1847–1859 (2022)
Valentin Max Vetter, Yasmine Sommerer, Christian Humberto Kalies, Dominik Spira, Lars Bertram & Ilja Demuth
Adverse effects of low vitamin D level on mortality and morbidity are controversially discussed.
Especially older people are at risk for vitamin D deficiency and therefore exposed to its potentially harmful consequences.
A way of measuring differences in the biological age is through DNA methylation age (DNAm age) and its deviation from chronological age, DNAm age acceleration (DNAmAA).
We previously reported on an association between vitamin D deficiency and higher 7-CpG DNAmAA in participants of the Berlin Aging Study II (BASE-II). In this study, we employ a quasi-interventional study design to assess the relationship between DNAmAA of five epigenetic clocks and vitamin D supplementation.
Longitudinal data were available for 1,036 participants of BASE-II that were reexamined on average 7.4 years later in the GendAge study (mean age at follow-up: 75.6 years, SD = 3.8 years, age range: 64.9–94.1 years, 51.9% female).
DNAmAA was estimated with the
- 7-CpG clock,
- Horvath’s clock,
- Hannum’s clock,
- PhenoAge, and
Methylation data were obtained through methylation-sensitive single nucleotide primer extension (MS-SNuPE) or Illumina’s Infinium “MethylationEPIC” array. Vitamin D–deficient participants who chose to start vitamin D supplementation after baseline examination showed a
- 2.6-year lower 7-CpG DNAmAA (p = 0.011) and
- 1.3-year lower Horvath DNAmAA (p = 0.042)
compared to untreated and vitamin D–deficient participants.
DNAmAA did not statistically differ between participants with successfully treated vitamin D deficiency and healthy controls (p > 0.16).
Therefore, we conclude that intake of vitamin D supplement is associated with lower DNAmAA in participants with vitamin D deficiency.
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Examine.com reviewed this study
A Review: Highlighting the Links between Epigenetics, COVID-19 Infection, and Vitamin D - Oct 2022
Int. J. Mol. Sci. 2022, 23(20), 12292; https://doi.org/10.3390/ijms232012292
by Ashmika Foolch etc.
The highly transmittable and infectious COVID-19 remains a major threat worldwide, with the elderly and comorbid individuals being the most vulnerable. While vaccines are currently available, therapeutic drugs will help ease the viral outbreak and prevent serious health outcomes. Epigenetic modifications regulate gene expression through changes in chromatin structure and have been linked to viral pathophysiology. Since epigenetic modifications contribute to the life cycle of the virus and host immune responses to infection, epigenetic drugs are promising treatment targets to ameliorate COVID-19. Deficiency of the multifunctional secosteroid hormone vitamin D is a global health threat. Vitamin D and its receptor function to regulate genes involved in immunity, apoptosis, proliferation, differentiation, and inflammation. Amassed evidence also indicates the biological relations of vitamin D with reduced disease risk, while its receptor can be modulated by epigenetic mechanisms. The immunomodulatory effects of vitamin D suggest a role for vitamin D as a COVID-19 therapeutic agent. Therefore, this review highlights the epigenetic effects on COVID-19 and vitamin D while also proposing a role for vitamin D in COVID-19 infections.
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VitaminDWiki is trying to arrange a 30,000 person vitamin D trial - which may show improved longevity
- Possible large Vitamin D intervention trial: Iceland, Saudi Arabia etc.
- Iceland and Vitamin D - many studies
2 Vitamin D megatrials (>5,000 people) on reducing all-cause mortality are underway - 2021
Investigational drugs and nutrients for human longevity. Recent clinical trials registered in ClinicalTrials.gov and clinicaltrialsregister.eu
https://doi.org/10.1080/13543784.2021.1939306 FREE PDF
See also VitaminDWiki
- Less likely to die of various causes if higher Vitamin D (data from 300,000 people) – Oct 2022
- COVID death 5.2X more likely if Vitamin D deficient – May 2022
- Mortality reduced by 35 percent if everyone had 50 ng of vitamin D - Grant Oct 2021
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